Alice L. Yu
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View article: Landscape of paediatric oncology clinical trials in Asia
Landscape of paediatric oncology clinical trials in Asia Open
View article: YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis
YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis Open
Background Through evolutionary genomics analysis, we identified Yulink (MIOS, Entrez Gene: 54,468), a highly conserved gene encoding an 875 amino acid protein with diverse functions in humans. Given the importance of accelerated glycolysi…
View article: Prevalence of vasculitis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies and spondyloarthritis in <scp>Australia</scp> : a systematic review and meta‐analysis
Prevalence of vasculitis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies and spondyloarthritis in <span>Australia</span> : a systematic review and meta‐analysis Open
Background Systemic autoimmune rheumatic diseases (SARDs), including vasculitis, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), spondyloarthritis (SpA), Sj…
View article: How Do Different Health States Impact Preferences for Social-Care-Related Quality of Life: An Exploration of EQ-5D-5L and Adult Social Care Outcomes Toolkit Using a Vignette Approach
How Do Different Health States Impact Preferences for Social-Care-Related Quality of Life: An Exploration of EQ-5D-5L and Adult Social Care Outcomes Toolkit Using a Vignette Approach Open
This study found limited influence of health context on valuation of social-care-related quality-of-life dimensions, providing evidence supporting development of ASCOT value sets independent of context.
View article: Robotic radical cystectomy, bilateral pelvic lymph node dissection and creation of intracorporeal ileal conduit in a woman with severe obesity
Robotic radical cystectomy, bilateral pelvic lymph node dissection and creation of intracorporeal ileal conduit in a woman with severe obesity Open
OBJECTIVES: Some patients undergoing radical cystectomy may benefit more than others from robot-assisted surgery. In overweight patients, open cystectomy can be particularly challenging, and these cases may be better suited for a robotic a…
View article: Enhancing retention and quality of tissue stromal vascular fraction graft with globo H ceramide
Enhancing retention and quality of tissue stromal vascular fraction graft with globo H ceramide Open
View article: Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion
Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion Open
Adenosine signaling is a crucial immunosuppressive pathway within the tumor microenvironment, making it a promising target for cancer therapy. In this study, it is demonstrated that Globo H ceramide (GHCer), the most prevalent tumor‐associ…
View article: Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy
Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy Open
Our present work suggests that increased autophagic impairment induced by the combination of CPT and TFPA contributes to the apoptotic cell death of lung cancer cells.
View article: ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling
ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling Open
View article: Racial and Ethnic Survival Disparities Among Children With High-Risk Neuroblastoma
Racial and Ethnic Survival Disparities Among Children With High-Risk Neuroblastoma Open
Importance Whether population-based racial and ethnic survival disparities for children with high-risk neuroblastoma persist in the clinical trial setting is unknown. Objective To investigate racial and ethnic survival disparities among ch…
View article: Bioactivities and Anti-Cancer Activities of NKT-Stimulatory Phenyl-Glycolipid Formulated with a PEGylated Lipid Nanocarrier
Bioactivities and Anti-Cancer Activities of NKT-Stimulatory Phenyl-Glycolipid Formulated with a PEGylated Lipid Nanocarrier Open
These findings demonstrate that the newly formulated PLN-C34 retains NKT-stimulatory activity and anti-cancer efficacy of C34, supporting the potential of PLN as a solvent for C34 for further development in cancer therapy.
View article: Effective suppression of tumor growth and hepatic metastasis of neuroblastoma by NKT-stimulatory phenyl glycolipid
Effective suppression of tumor growth and hepatic metastasis of neuroblastoma by NKT-stimulatory phenyl glycolipid Open
Invariant natural killer T cell (iNKT) cells produce large amounts of cytokines in response to α-Galactosylceramide (α-GalCer) stimulation. An analog containing two phenyl rings on the acyl chain, C34, was previously found to be more Th1-b…
View article: Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor Open
Background Atypical teratoid rhabdoid tumors (ATRT) is a rare but aggressive malignancy in the central nervous system, predominantly occurring in early childhood. Despite aggressive treatment, the prognosis of ATRT patients remains poor. R…
View article: PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions Open
View article: Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group
Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group Open
In Asia, a few countries have a long and established history of collaborative clinical trials successfully formed national children's cancer study groups, but many still do not have such groups. The process of forming national children's c…
View article: Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing Open
CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and cancers, but safety could be a concern. Here we use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the …
View article: High expression of embryonic stem cell marker SSEA3 confers poor prognosis and promotes epithelial mesenchymal transition in hepatocellular carcinoma
High expression of embryonic stem cell marker SSEA3 confers poor prognosis and promotes epithelial mesenchymal transition in hepatocellular carcinoma Open
Higher expression of SSEA3 was an independent predictor for RFS and OS in HCC and promoted EMT of HCC via upregulation of ZEB1.
View article: Impact of diagnostic and end‐of‐induction Curie scores with tandem high‐dose chemotherapy and autologous transplants for metastatic high‐risk neuroblastoma: A report from the Children's Oncology Group
Impact of diagnostic and end‐of‐induction Curie scores with tandem high‐dose chemotherapy and autologous transplants for metastatic high‐risk neuroblastoma: A report from the Children's Oncology Group Open
Background Diagnostic mIBG (meta‐iodobenzylguanidine) scans are an integral component of response assessment in children with high‐risk neuroblastoma. The role of end‐of‐induction (EOI) Curie scores (CS) was previously described in patient…
View article: The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells
The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells Open
Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-deriv…
View article: ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors
ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors Open
View article: Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Altered glycosylations, which are associated with expression and activities of glycosyltransferases, can dramatically affect the function of glycoproteins and modify the behavior of tumor cells. ST3GAL1 is a sialyltransferase that adds sia…
View article: Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Altered glycosylations, which are associated with expression and activities of glycosyltransferases, can dramatically affect the function of glycoproteins and modify the behavior of tumor cells. ST3GAL1 is a sialyltransferase that adds sia…
View article: Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Supplementary figure S1-S5
View article: Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Supplementary figure S1-S5
View article: De-identified ID of the patients included in the RG cohort from <i>GFPT2</i>-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma
De-identified ID of the patients included in the RG cohort from <i>GFPT2</i>-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma Open
This supplement file contains a list of de-identified IDs of the patients included in the RG cohort data available online.
View article: Supplementary Data from A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma
Supplementary Data from A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma Open
Tables of antibody infusion times and Curie Scores
View article: Supplementary Information from Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032
Supplementary Information from Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032 Open
Figure S1a, Figure S1b; Supplementary Tables S1-S7
View article: Table S1 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group
Table S1 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group Open
KIR/KIR-ligand genotypes that determine KIR-ligands present vs. KIR-ligand missing status for this report.
View article: Table S2 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group
Table S2 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group Open
Incidence of KIR/KIR-ligand genotypes in the patients analyzed.
View article: Table S4 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group
Table S4 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group Open
Clinical characteristics of COG patients, according to treatment group, for all patients and for those genotyped for KIR/KIR-ligand.