Alice Lessing
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View article: A tailored enzyme cascade facilitates DNA-encoded library technology and gives access to a broad substrate scope
A tailored enzyme cascade facilitates DNA-encoded library technology and gives access to a broad substrate scope Open
DNA-encoded chemical library (DEL) technology has emerged as a powerful tool in early-stage drug discovery. Although the methodology is widely applied in industry and academia, major challenges persist in generating DELs with high quality …
View article: Native Massenspektrometrie erleichtert die Hit‐Validierung in der DNA‐Encoded Library Technologie
Native Massenspektrometrie erleichtert die Hit‐Validierung in der DNA‐Encoded Library Technologie Open
Zusammenfassung Die DNA‐encoded Library (DEL) Technologie hat sich als zentrales Instrument der Wirkstoffentwicklung etabliert und wird sowohl in der Industrie als auch in der akademischen Forschung breit eingesetzt. Eine zunehmende Anzahl…
View article: Native Mass Spectrometry Facilitates Hit Validation in DNA‐Encoded Library Technology
Native Mass Spectrometry Facilitates Hit Validation in DNA‐Encoded Library Technology Open
DNA‐encoded Library (DEL) Technology has become a workhorse of drug development, is widely employed in an industrial and academic setting, and an increasing number of drugs developed by DEL technology have entered clinical stage developmen…
View article: Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery
Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery Open
View article: Universal encoding of next generation DNA-encoded chemical libraries
Universal encoding of next generation DNA-encoded chemical libraries Open
Large Encoding Design (LED) allows for the construction of DNA-encoded chemical libraries (DELs) of unprecedented sizes and designs. LED was validated and compared with previous encoding systems for amplifiability and performance in test s…