Alice Maguolo
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View article: Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes
Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes Open
Background White adipose tissue (WAT) dysfunction including an aberrant expression of miRNAs is strongly associated with the risk of developing type 2 diabetes (T2D), with limited evidence linking early changes in the WAT-derived miRNAs an…
View article: Epigenetic biomarkers predict macrovascular events in individuals with type 2 diabetes
Epigenetic biomarkers predict macrovascular events in individuals with type 2 diabetes Open
Prediction of incident macrovascular events (iMEs) in individuals with type 2 diabetes (T2D) remains suboptimal. We aim to discover blood-based epigenetic biomarkers predicting iMEs in 752 newly diagnosed individuals with T2D, among whom 1…
View article: Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood
Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood Open
We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pair…
View article: Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity Open
Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort…
View article: Blood-Based Epigenetic Biomarkers Associated With Incident Chronic Kidney Disease in Individuals With Type 2 Diabetes
Blood-Based Epigenetic Biomarkers Associated With Incident Chronic Kidney Disease in Individuals With Type 2 Diabetes Open
There is an increasing need for new biomarkers to improve prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop…
View article: Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes
Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes Open
There is an increasing need for new biomarkers improving prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop …
View article: Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes
Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes Open
There is an increasing need for new biomarkers improving prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop …
View article: <scp>D</scp><scp>NA</scp> methylation in cord blood partially mediates the effects of prepregnancy <scp>BMI</scp> on early childhood offspring <scp>BMI</scp>
<span>D</span><span>NA</span> methylation in cord blood partially mediates the effects of prepregnancy <span>BMI</span> on early childhood offspring <span>BMI</span> Open
Objective We investigated whether prepregnancy BMI (prePregBMI) in women with obesity was associated with differential DNA methylation (DNAm) in cord blood (CB) and whether DNAm may mediate the association of prePregBMI and early childhood…
View article: Feasibility and effectiveness of a distance-adapted physical activity intervention in adolescents with obesity during the COVID-19 pandemic
Feasibility and effectiveness of a distance-adapted physical activity intervention in adolescents with obesity during the COVID-19 pandemic Open
BACKGROUND: Pediatric obesity represents one of the most important public health challenges and its prevalence significantly increased during the COVID-19 pandemic. Our prospective study aimed to assess the feasibility of a remote adapted …
View article: Micronutrients in early life and offspring metabolic health programming: a promising target for preventing non-communicable diseases
Micronutrients in early life and offspring metabolic health programming: a promising target for preventing non-communicable diseases Open
View article: IGF1 and PPARG polymorphisms are associated with reduced estimated glomerular filtration rate in a cohort of children and adolescents with type 1 diabetes
IGF1 and PPARG polymorphisms are associated with reduced estimated glomerular filtration rate in a cohort of children and adolescents with type 1 diabetes Open
Introduction Several genetic loci have been associated with diabetic nephropathy; however, the underlying genetic mechanisms are still poorly understood, with no robust candidate genes identified yet. Aim We aimed to determine whether two …
View article: The treatment of obesity in children and adolescents: consensus position statement of the Italian society of pediatric endocrinology and diabetology, Italian Society of Pediatrics and Italian Society of Pediatric Surgery
The treatment of obesity in children and adolescents: consensus position statement of the Italian society of pediatric endocrinology and diabetology, Italian Society of Pediatrics and Italian Society of Pediatric Surgery Open
View article: Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity
Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity Open
Metabolic syndrome (MetS) is defined by a cluster of several cardio-metabolic risk factors, specifically visceral obesity, hypertension, dyslipidemia, and impaired glucose metabolism, which together increase risks of developing future card…
View article: Oral Microbiota in Children and Adolescents with Type 1 Diabetes Mellitus: Novel Insights into the Pathogenesis of Dental and Periodontal Disease
Oral Microbiota in Children and Adolescents with Type 1 Diabetes Mellitus: Novel Insights into the Pathogenesis of Dental and Periodontal Disease Open
The oral microbiota can be influenced by multiple factors, but only a few studies have focused on the role of glycemic control in determining early alterations of oral microbiota and their association with pathogenesis of both periodontiti…
View article: From Metabolic Syndrome to Type 2 Diabetes in Youth
From Metabolic Syndrome to Type 2 Diabetes in Youth Open
In the frame of metabolic syndrome, type 2 diabetes emerges along a continuum of the risk from the clustering of all its components, namely visceral obesity, high blood pressure and lipids, and impaired glucose homeostasis. Insulin resista…
View article: Correction to: A new proposal for a second insulin bolus to optimize postprandial glucose profile in adolescents with type 1 diabetes
Correction to: A new proposal for a second insulin bolus to optimize postprandial glucose profile in adolescents with type 1 diabetes Open
View article: The burden of low back pain in children and adolescents with overweight and obesity: from pathophysiology to prevention and treatment strategies
The burden of low back pain in children and adolescents with overweight and obesity: from pathophysiology to prevention and treatment strategies Open
Nonspecific low back pain (LBP) is one of the most common causes of disability, affecting all individuals at least once in their lifetime. Such a condition is also becoming increasingly frequent in the pediatric population, especially in c…
View article: Pros and Cons of Current Diagnostic Tools for Risk-Based Screening of Prediabetes and Type 2 Diabetes in Children and Adolescents with Overweight or Obesity
Pros and Cons of Current Diagnostic Tools for Risk-Based Screening of Prediabetes and Type 2 Diabetes in Children and Adolescents with Overweight or Obesity Open
It is still a matter of debate which is the most suitable diagnostic test for risk-based screening of prediabetes and type 2 diabetes (T2D) in children and adolescents with overweight or obesity. This review highlighted benefits and pitfal…
View article: Early marker of ocular neurodegeneration in children and adolescents with type 1 diabetes: the contributing role of polymorphisms in mir146a and mir128a genes
Early marker of ocular neurodegeneration in children and adolescents with type 1 diabetes: the contributing role of polymorphisms in mir146a and mir128a genes Open
Background Early ocular neurodegenerative signs of diabetic neuropathy (DN) can be found in children and adolescents with type 1 diabetes (T1D). No data are available on the potential role of polymorphisms in miRNAs genes in predisposing T…
View article: Serum zonulin as an index of glucose dysregulation in children and adolescents with overweight and obesity
Serum zonulin as an index of glucose dysregulation in children and adolescents with overweight and obesity Open
Summary Increased intestinal permeability has an important role in metabolic dysregulation. In this cross‐sectional study, we examined whether serum intestinal permeability marker zonulin and related pro‐inflammatory molecules were associa…
View article: A Gain-of-Function Mutation on BCKDK Gene and Its Possible Pathogenic Role in Branched-Chain Amino Acid Metabolism
A Gain-of-Function Mutation on BCKDK Gene and Its Possible Pathogenic Role in Branched-Chain Amino Acid Metabolism Open
BCKDK is an important key regulator of branched-chain ketoacid dehydrogenase complex activity by phosphorylating and so inactivating branched-chain ketoacid dehydrogenases, the rate-limiting enzyme of the branched-chain amino acid metaboli…
View article: Supplementary Material for: Cardiovascular risk factors in children and adolescents with type 1 diabetes mellitus: the role of insulin resistance and associated genetic variants
Supplementary Material for: Cardiovascular risk factors in children and adolescents with type 1 diabetes mellitus: the role of insulin resistance and associated genetic variants Open
Introduction: Type 1 diabetes (T1D) is associated with increased risk of cardiovascular disease. Insulin resistance is an important cardiovascular risk factor (CVRF), also in subjects with T1D, but the influence of the genetic predispositi…
View article: Newborn Screening for Biotinidase Deficiency. The Experience of a Regional Center in Italy
Newborn Screening for Biotinidase Deficiency. The Experience of a Regional Center in Italy Open
Introduction: Biotinidase deficiency (BD) is an autosomal recessive disease causing a defect in the biotin-releasing enzyme. Newborn screening (NBS) allows early diagnosis and treatment, ensuring excellent prognosis. The aim of this study …
View article: Diagnosis, genetic characterization and clinical follow up of mitochondrial fatty acid oxidation disorders in the new era of expanded newborn screening: A single centre experience
Diagnosis, genetic characterization and clinical follow up of mitochondrial fatty acid oxidation disorders in the new era of expanded newborn screening: A single centre experience Open
Our study highlighted the great phenotypic variability and molecular heterogeneity of FAODs and confirmed the importance of a tailored follow up and treatment. Despite the short duration of follow up, early identification by NBS prevented …
View article: Clinical pitfalls in the diagnosis of segmental overgrowth syndromes: a child with the c.2740G > A mutation in PIK3CA gene
Clinical pitfalls in the diagnosis of segmental overgrowth syndromes: a child with the c.2740G > A mutation in PIK3CA gene Open