Alice Maiocchi
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View article: Asymmetric Total Synthesis of (−)‐Glycybridin B, a Pharmacophore Screened Candidate for Tubulin Binding
Asymmetric Total Synthesis of (−)‐Glycybridin B, a Pharmacophore Screened Candidate for Tubulin Binding Open
Microtubule‐targeting agents (MTAs) represent a pivotal class of therapeutic compounds designed to disrupt microtubule dynamics, leading to cell cycle arrest and apoptosis in malignant cells. Nevertheless, their off‐target effects on healt…
View article: Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras
Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras Open
Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that induce the degradation of proteins of interest (POIs) via the ubiquitin-proteasome pathway by recruiting E3 ligases to form a ternary complex with the POI. In t…
View article: Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats
Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats Open
View article: An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB Open
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a neurodegenerative pathology caused by accumulation of mutant neuroserpin (NS) polymers inside the endoplasmic reticulum (ER) of neurons, leading to cellular toxicity an…
View article: Design, Synthesis and Characterization of Aryl Bis-Guanyl Hydrazones as Rna Binders of C9orf72 G4c2 Extended Repeats
Design, Synthesis and Characterization of Aryl Bis-Guanyl Hydrazones as Rna Binders of C9orf72 G4c2 Extended Repeats Open
View article: Stereoselective Synthetic Strategies to (−)‐Cannabidiol
Stereoselective Synthetic Strategies to (−)‐Cannabidiol Open
(−)‐Cannabidiol (CBD) is a non‐psychoactive compound that has already found many medical applications, from the treatment of epilepsy to other neurological disorders. (−)‐CBD is usually extracted from Cannabis Sativa , but unfortunately, i…
View article: CCDC 2161746: Experimental Crystal Structure Determination
CCDC 2161746: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Total Synthesis of (−)‐Cannabidiol‐C<sub>4</sub>
Total Synthesis of (−)‐Cannabidiol‐C<sub>4</sub> Open
Cannabidiol‐C 4 1 (CBD‐C 4 , cannabidibutol) is a natural product that is present in the extracts of Cannabis . Its isolation has not been reported to date. The aim of the proposed synthesis is to secure the availability of the pure compou…