Alice McDouall
YOU?
Author Swipe
View article: Tonabersat Inhibits Retinal Inflammation After Hypoxia–Ischemia in the Neonatal Rat
Tonabersat Inhibits Retinal Inflammation After Hypoxia–Ischemia in the Neonatal Rat Open
Perinatal hypoxic–ischemic encephalopathy (HIE) is a condition resulting from oxygen deprivation around the time of birth and may be associated with death, brain damage, and disability. Alongside this, studies have shown that HIE may resul…
View article: What are the implications of sex differences in cell death for treatment after neonatal hypoxia-ischemia, if any?
What are the implications of sex differences in cell death for treatment after neonatal hypoxia-ischemia, if any? Open
View article: Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep
Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep Open
Background The optimal rate to rewarm infants after therapeutic hypothermia is unclear. In this study we examined whether slow rewarming after 72 h of hypothermia would attenuate white matter injury. Methods Near-term fetal sheep received …
View article: Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep
Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep Open
Antenatal hypoxia-ischaemia (HI) in preterm fetal sheep can trigger delayed evolution of severe, cystic white matter injury (WMI), in a similar timecourse to WMI in preterm infants. We therefore examined how severe hypoxia-ischaemia affect…
View article: Blockade of connexin hemichannels with tonabersat protects against mild hypoxic ischemic brain injury in neonatal rats
Blockade of connexin hemichannels with tonabersat protects against mild hypoxic ischemic brain injury in neonatal rats Open
Blockade of connexin hemichannels with tonabersat significantly reduced mild HI injury in the hippocampus and white matter, without causing hypothermia.
View article: Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury
Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury Open
Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants sti…
View article: Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep
Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep Open
Background Therapeutic hypothermia significantly improves outcomes after moderate–severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. Although hypothermia is consistently associated with reduced microgliosis, it is…
View article: Challenges in developing therapeutic strategies for mild neonatal encephalopathy
Challenges in developing therapeutic strategies for mild neonatal encephalopathy Open
There is increasing evidence that infants with mild neonatal encephalopathy (NE) have significant risks of mortality, brain injury and adverse neurodevelopmental outcomes. In the era of therapeutic hypothermia, infants need to be diagnosed…
View article: Treating Seizures after Hypoxic-Ischemic Encephalopathy—Current Controversies and Future Directions
Treating Seizures after Hypoxic-Ischemic Encephalopathy—Current Controversies and Future Directions Open
Seizures are common in newborn infants with hypoxic-ischemic encephalopathy and are highly associated with adverse neurodevelopmental outcomes. The impact of seizure activity on the developing brain and the most effective way to manage the…