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View article: Activation of Ca<sup>2+</sup>phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy
Activation of Ca<sup>2+</sup>phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy Open
Selective removal of dysfunctional mitochondria via autophagy is crucial for the maintenance of cellular homeostasis. This event is initiated by the translocation of the E3 ubiquitin ligase Parkin to damaged mitochondria, and it requires t…
View article: Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System Open
The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI. However, a chem…
View article: Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease
Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease Open
Parkinson's Disease (PD) related genes PINK1, a protein kinase [1], and Parkin, an E3 ubiquitin ligase [2], operate within the same pathway [3-5], which controls, via specific elimination of dysfunctional mitochondria, the quality of the o…
View article: Analysis of the role of mitochondrial morphology in autophagy
Analysis of the role of mitochondrial morphology in autophagy Open
PARK2 gene encodes for an E3 ubiquitin ligase called Parkin. Loss-of-function mutations in this gene cause early onset of Parkinsonâs disease, a neurodegenerative disorder of unknown etiology. The role of Parkin in neuron maintenance is …