Alice Nicolas
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View article: Reducing Glioblastoma Cell Aggressiveness via Static and Dynamic Magneto-Mechanical Stimulation with Vortex Microdiscs on Substrates of Physiological Stiffness
Reducing Glioblastoma Cell Aggressiveness via Static and Dynamic Magneto-Mechanical Stimulation with Vortex Microdiscs on Substrates of Physiological Stiffness Open
External mechanical stresses acting on cellular compartments critically regulate cell behaviour and can induce cell death. Magnetically actuated particles present a promising strategy to apply such forces in a controlled manner, with poten…
View article: Modelling of magnetic vortex microdisc dynamics under varying magnetic field in biological viscoelastic environments
Modelling of magnetic vortex microdisc dynamics under varying magnetic field in biological viscoelastic environments Open
Magnetically driven microparticles provide a versatile platform for probing and manipulating biological systems, yet the physical framework governing their actuation in complex environments remains only partially explored. Within the field…
View article: Stimulation mécanique de cellules vivantes par vibrations de particules magnétiques
Stimulation mécanique de cellules vivantes par vibrations de particules magnétiques Open
Des particules magnétiques dispersées parmi des cellules vivantes et soumises à un champ magnétique variable permettent d’exercer une stimulation mécanique des cellules et d’induire des réactions physiologiques. Des études ont montré que c…
View article: Magnetism for mechanobiology and related biomedical applications
Magnetism for mechanobiology and related biomedical applications Open
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View article: Substrate softness increases magnetic microdiscs-induced cytotoxicity
Substrate softness increases magnetic microdiscs-induced cytotoxicity Open
Cells grown on soft substrates take up more nanoparticles and exhibit a higher susceptibility to them at similar particle load.
View article: Soft extracellular matrix drives endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells
Soft extracellular matrix drives endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells Open
View article: Magneto-mechanical stimulation of living cells: towards innovative therapies based on mechanobiological effects
Magneto-mechanical stimulation of living cells: towards innovative therapies based on mechanobiological effects Open
Cellular mechano-sensitivity can be exploited to modify cellular functions, opening the doors to the design of innovative therapies. This can be very efficiently achieved through the use of magnetic microparticles dispersed among the cells…
View article: Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells
Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells Open
Cell culture on soft matrix, either in 2D and 3D, preserves the characteristics of progenitors. However, the mechanism by which the mechanical microenvironment determines progenitor phenotype, and its relevance to human biology, remains po…
View article: Impact of baculoviral transduction of fluorescent actin on cellular forces
Impact of baculoviral transduction of fluorescent actin on cellular forces Open
Live staining of actin brings valuable information in the field of mechanobiology. Gene transfer of GFP-actin has been reported to disturb cell rheological properties while gene transfer of fluorescent actin binding proteins was not. Howev…
View article: Soft Extracellular Matrix Drives an Endoplasmic Reticulum Stress-Dependent S Quiescence Underlying Molecular Traits of Pulmonary Basal Cells
Soft Extracellular Matrix Drives an Endoplasmic Reticulum Stress-Dependent S Quiescence Underlying Molecular Traits of Pulmonary Basal Cells Open
View article: Force tuning through regulation of clathrin-dependent integrin endocytosis
Force tuning through regulation of clathrin-dependent integrin endocytosis Open
Integrin endocytosis is essential for many fundamental cellular processes. Whether and how the internalization impacts cellular mechanics remains elusive. Whereas previous studies reported the contribution of the integrin activator, talin,…
View article: Quantifying active and resistive stresses in adherent cells
Quantifying active and resistive stresses in adherent cells Open
To understand cell migration, it is crucial to gain knowledge on how cells exert and integrate forces on and from their environment. A quantity of prime interest for biophysicists interested in cell movements modeling is the intracellular …
View article: Measuring the average cell size and width of its distribution in cellular tissues using Fourier transform
Measuring the average cell size and width of its distribution in cellular tissues using Fourier transform Open
View article: Poly-<scp>l</scp>-lysine/Laminin Surface Coating Reverses Glial Cell Mechanosensitivity on Stiffness-Patterned Hydrogels
Poly-<span>l</span>-lysine/Laminin Surface Coating Reverses Glial Cell Mechanosensitivity on Stiffness-Patterned Hydrogels Open
Brain tissues demonstrate heterogeneous mechanical properties, which evolve with aging and pathologies. The observation in these tissues of smooth to sharp rigidity gradients raises the question of brain cell responses to both different va…
View article: Cells on Hydrogels with Micron-Scaled Stiffness Patterns Demonstrate Local Stiffness Sensing
Cells on Hydrogels with Micron-Scaled Stiffness Patterns Demonstrate Local Stiffness Sensing Open
Cell rigidity sensing—a basic cellular process allowing cells to adapt to mechanical cues—involves cell capabilities exerting force on the extracellular environment. In vivo, cells are exposed to multi-scaled heterogeneities in the mechani…
View article: The Micromechanical Signature of Pituitary Adenomas: New Perspectives for the Diagnosis and Surgery
The Micromechanical Signature of Pituitary Adenomas: New Perspectives for the Diagnosis and Surgery Open
MechanobiologyStiffness measurement using atomic force microscopy shows that pituitary adenomas tissues are two orders of magnitude softer than normal tissues, independent of the type of hormonal secretion. This observation opens perspecti…
View article: Linear correlation between active and resistive stresses informs on\n force generation and stress transmission in adherent cells
Linear correlation between active and resistive stresses informs on\n force generation and stress transmission in adherent cells Open
Animal cells are active, contractile objects. While bioassays address the\nmolecular characterization of cell contractility, the mechanical\ncharacterization of the active forces in cells remains challenging. Here by\nconfronting theoretic…
View article: Linear correlation between active and resistive stresses informs on force generation and stress transmission in adherent cells
Linear correlation between active and resistive stresses informs on force generation and stress transmission in adherent cells Open
Animal cells are active, contractile objects. While bioassays address the molecular characterization of cell contractility, the mechanical characterization of the active forces in cells remains challenging. Here by confronting theoretical …
View article: The Micromechanical Signature of Pituitary Adenomas: New Perspectives for the Diagnosis and Surgery
The Micromechanical Signature of Pituitary Adenomas: New Perspectives for the Diagnosis and Surgery Open
Pituitary adenomas are common tumors in the skull base that are associated with significant morbidity due to local compressive effects, hormonal hypersecretion, or treatment‐associated endocrine deficiency. Pituitary adenomas are often sur…
View article: Measuring the average cell size and width of its distribution in cellular tissues using Fourier Transform
Measuring the average cell size and width of its distribution in cellular tissues using Fourier Transform Open
We present an in-depth investigation of a fully automated Fourier-based analysis to determine the cell size and the width of its distribution in 3D biological tissues. The results are thoroughly tested using generated images, and we offer …
View article: High temperature dikes in mantle peridotites: origin by hydraulic fracturing during plastic flow
High temperature dikes in mantle peridotites: origin by hydraulic fracturing during plastic flow Open