Alice Piapi
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View article: HOX gene expression in the developing human spine
HOX gene expression in the developing human spine Open
View article: Single‐cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of <scp>WT1</scp> kidney disease
Single‐cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of <span>WT1</span> kidney disease Open
WT1 encodes a podocyte transcription factor whose variants can cause an untreatable glomerular disease in early childhood. Although WT1 regulates many podocyte genes, it is poorly understood which of them are initiators in disease and how …
View article: Transcriptional signals of transformation in human cancer
Transcriptional signals of transformation in human cancer Open
View article: 48th Annual Meeting of the International Society for Pediatric Neurosurgery
48th Annual Meeting of the International Society for Pediatric Neurosurgery Open
View article: Transcriptional signals of dedifferentiation in human cancer
Transcriptional signals of dedifferentiation in human cancer Open
As normal cells transform into cancers, their cell state changes (or “dedifferentiates”), which may drive cancer cells into a stem-like or more primordial, foetal or embryonic cell state. Here, we used single cell atlases to study dediffer…
View article: Targeting of low ALK antigen density neuroblastoma using AND logic-gate engineered CAR-T cells
Targeting of low ALK antigen density neuroblastoma using AND logic-gate engineered CAR-T cells Open
These data provide further proof of concept for ALK as a neuroblastoma CAR T-cell target.
View article: Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney disease
Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney disease Open
The glomerulus mediates kidney ultrafiltration through specialised epithelial cells called podocytes which line a basement membrane shared with blood capillary endothelium. Cell-cell crosstalk is critical for glomerular function, but its i…
View article: Precise identification of cancer cells from allelic imbalances in single cell transcriptomes
Precise identification of cancer cells from allelic imbalances in single cell transcriptomes Open
View article: Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia Open
View article: Single cell mRNA signals reveal a distinct developmental state of <i>KMT2A</i>-rearranged infant B-cell acute lymphoblastic leukemia
Single cell mRNA signals reveal a distinct developmental state of <i>KMT2A</i>-rearranged infant B-cell acute lymphoblastic leukemia Open
Infant B-cell acute lymphoblastic leukemia (B-ALL) has not followed the increasing trend towards cure seen in other childhood B-ALLs. The prognosis for infants with KMT2A gene fusions is especially poor, and the origins of this aggressive …
View article: Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction
Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction Open
Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellul…
View article: Single cell derived mRNA signals across human kidney tumors
Single cell derived mRNA signals across human kidney tumors Open
View article: Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell Open
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma …
View article: Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell Open
Neuroblastoma is an embryonal childhood cancer that arises from aberrant development of the neural crest, mostly within the fetal adrenal medulla. It is not established what developmental processes neuroblastoma cancer cells represent. Her…
View article: Tumor-Resident Dendritic Cells and Macrophages Modulate the Accumulation of TCR-Engineered T Cells in Melanoma
Tumor-Resident Dendritic Cells and Macrophages Modulate the Accumulation of TCR-Engineered T Cells in Melanoma Open
Ongoing clinical trials explore T cell receptor (TCR) gene therapy as a treatment option for cancer, but responses in solid tumors are hampered by the immunosuppressive microenvironment. The production of TCR gene-engineered T cells requir…