A. Gordon James
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View article: The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
The Aging Landscape by <span>scRNAseq</span> of Mesenchymal Lineage Cells in Mouse Bone Open
A decrease in osteoblast number and bone formation are seminal contributors to age‐related osteoporosis. However, the aging‐associated molecular mechanisms that impact osteoblast precursors, osteoblasts, osteocytes, and other bone mesenchy…
View article: Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength Open
Autophagy is a recycling pathway in which damaged proteins, protein aggregates, and organelles are delivered to lysosomes for degradation. Autophagy insufficiency is thought to contribute to osteoporosis. Accordingly, autophagy elimination…
View article: Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness Open
Exercise-induced mechanical load stimulates bone cells, including osteocytes, to promote bone formation. The bone response to loading is less effective with aging, but the cellular and molecular mechanisms responsible for the impaired mech…
View article: CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength Open
Autophagy is a recycling pathway in which damaged or dysfunctional proteins, protein aggregates, and organelles are delivered to lysosomes for degradation. Insufficiency of autophagy is thought to contribute to several age-related diseases…
View article: Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice Open
Chaperone‐mediated autophagy (CMA) is a lysosome‐dependent degradation pathway that eliminates proteins that are damaged, partially unfolded, or targeted for selective proteome remodeling. CMA contributes to several cellular processes, inc…
View article: Intrinsic and extrinsic factors affecting axillary odor variation. A comprehensive review
Intrinsic and extrinsic factors affecting axillary odor variation. A comprehensive review Open
Humans produce odorous secretions from multiple body sites according to the microbiomic profile of each area and the types of secretory glands present. Because the axilla is an active, odor-producing region that mediates social communicati…
View article: The molecular basis of thioalcohol production in human body odour
The molecular basis of thioalcohol production in human body odour Open
Body odour is a characteristic trait of Homo sapiens , however its role in human behaviour and evolution is poorly understood. Remarkably, body odour is linked to the presence of a few species of commensal microbes. Herein we discover a ba…
View article: Structural basis of malodour precursor transport in the human axilla
Structural basis of malodour precursor transport in the human axilla Open
Mammals produce volatile odours that convey different types of societal information. In Homo sapiens, this is now recognised as body odour, a key chemical component of which is the sulphurous thioalcohol, 3-methyl-3-sulfanylhexan-1-ol (3M3…
View article: Author response: Structural basis of malodour precursor transport in the human axilla
Author response: Structural basis of malodour precursor transport in the human axilla Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mammals produce volatile odou…