Alicia Algaba
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View article: Predictive regression models for cognitive impairment, dementia, and Alzheimer’s disease using real-world electronic health records
Predictive regression models for cognitive impairment, dementia, and Alzheimer’s disease using real-world electronic health records Open
The aim of this non-interventional, case–control pilot study was to identify factors associated with cognitive impairment, dementia, and Alzheimer’s disease (AD) using a real-world dataset from Quirónsaludmadrid’s database. Based on Global…
View article: A predictive regression model for mild cognitive impairment and Alzheimer´s disease using real‐world electronic health records
A predictive regression model for mild cognitive impairment and Alzheimer´s disease using real‐world electronic health records Open
Background Identifying individuals with early Alzheimer’s disease, i.e. mild cognitive impairment (MCI) and mild dementia due to Alzheimer’s disease (AD) can facilitate the rapid initiation of pharmacological and non‐pharmacological therap…
View article: P817 Incidence and risk factors of infection in patients with inflammatory bowel disease: longitudinal prospective INFEII registry of GETECCU
P817 Incidence and risk factors of infection in patients with inflammatory bowel disease: longitudinal prospective INFEII registry of GETECCU Open
Background The true effect of having IBD in the development of infections has not been studied in depth since cohort studies are scarce and the results of studies are sometimes contradictory. Especially, this complication has not been addr…
View article: Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients
Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients Open
Background and Aims Inflammatory bowel disease (IBD) is a prevalent chronic noncurable disease associated with profound metabolic changes. The discovery of novel molecular indicators for unraveling IBD etiopathogenesis and the diagnosis an…
View article: Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells)
Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells) Open
Our research group has been developing a series of biological drugs produced by coculture techniques with M2-polarized macrophages with different primary tissue cells and/or mesenchymal stromal cells (MSC), generally from fat, to produce a…
View article: Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM)
Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM) Open
Intercellular communication between monocytes/macrophages and cells involved in tissue regeneration, such as mesenchymal stromal cells (MSCs) and primary tissue cells, is essential for tissue regeneration and recovery of homeostasis. Typic…
View article: Sucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment
Sucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment Open
Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial® iron (SI) may represent an alternative. This pro…
View article: P625 Characteristics of SARS-CoV-2 infection in IBD patients in the second and third wave compared with the first wave and with the data of general population
P625 Characteristics of SARS-CoV-2 infection in IBD patients in the second and third wave compared with the first wave and with the data of general population Open
Background Our aims were: 1.) to compare the characteristics of SARS-CoV-2 infection in IBD patients in the second and third wave with respect to the results published in our site in the first wave (I. Guerra et al. Inflamm Bowel Dis. 2021…
View article: Effectiveness and Safety of Ustekinumab in Ulcerative Colitis: Real-world Evidence from the ENEIDA Registry
Effectiveness and Safety of Ustekinumab in Ulcerative Colitis: Real-world Evidence from the ENEIDA Registry Open
Background and Aims The development programm UNIFI has shown promising results of ustekinumab in ulcerative colitis [UC] treatment which should be confirmed in clinical practice. We aimed to evaluate the durability, effectiveness, and safe…
View article: Incidence, Clinical Characteristics, and Evolution of SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: A Single-Center Study in Madrid, Spain
Incidence, Clinical Characteristics, and Evolution of SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: A Single-Center Study in Madrid, Spain Open
Background There are scarce data about SARS-CoV-2 infection in patients with inflammatory bowel disease (IBD). Our aim was to analyze the incidence, clinical presentation, and severity of SARS-CoV-2 infection in patients with IBD. Methods …
View article: P774 Low adhesion to latent tuberculosis (TB) screening recommendations in inflammatory bowel disease (IBD) patients: Results of the INFEII registry of GETECCU
P774 Low adhesion to latent tuberculosis (TB) screening recommendations in inflammatory bowel disease (IBD) patients: Results of the INFEII registry of GETECCU Open
Background INFEII registry (ClinicalTrials.gov: NCT02904590) is a prospective study promoted by GETECCU to determine the incidence and risk factors of infection in an inception cohort of IBD patients. Despite preventive measures and recomm…
View article: P816 Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease
P816 Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease Open
Loss-of-function (LoF) variants are one of the most interesting forms of rare functional genetic variations as they impair the function of a gene and are more likely to lead to extreme phenotypes. Our aim was to know the impact of function…
View article: P443 Clinical features, therapeutic requirements, and evolution of patients with Crohn's disease and upper digestive tract involvement (CROHNEX study)
P443 Clinical features, therapeutic requirements, and evolution of patients with Crohn's disease and upper digestive tract involvement (CROHNEX study) Open
Patients with upper (L4) and diffuse (L1 + L4) Crohn's disease (CD) may have a more aggressive and refractory disease course. However, evidence on this particular sub-type of patients is scarce. Clinical guidelines do not offer specific pr…
View article: Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial
Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial Open
Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, c…
View article: P275 Clinical characteristics, associated malignancies and management of primary sclerosing colangitis in inflammatory bowel disease patients: A Spanish nationwide study based on the ENEIDA registry
P275 Clinical characteristics, associated malignancies and management of primary sclerosing colangitis in inflammatory bowel disease patients: A Spanish nationwide study based on the ENEIDA registry Open
Primary sclerosing colangitis (PSC) is a chronic cholestasic liver disease usually associated with inflammatory bowel disease (IBD). An increased risk of malignancies (colorectal cancer and cholangiocarcinoma) has been reported in IBD pati…
View article: P631 Treatment of established post-operative recurrence of Crohn’s disease with anti-TNF agents: Preliminary data of a multicentre, nationwide study
P631 Treatment of established post-operative recurrence of Crohn’s disease with anti-TNF agents: Preliminary data of a multicentre, nationwide study Open
Thiopurines are the treatment of choice for the prevention of postoperative recurrence (POR) in Crohn’s disease (CD) in high-risk patients, whereas those at low risk should be monitored and treated only in case POR occurs. Endoscopic asses…
View article: P397 Effectiveness of vedolizumab (VDZ) for the induction of remission in inflammatory bowel disease (IBD): Results from the Spanish Eneida Registry
P397 Effectiveness of vedolizumab (VDZ) for the induction of remission in inflammatory bowel disease (IBD): Results from the Spanish Eneida Registry Open
The aims of this study were (1) to assess the effectiveness of VDZ in IBD patients and (2) to identify factors associated with the response to the treatment. IBD patients [Crohn’s disease (CD) and ulcerative colitis (UC)] that had received…
View article: Fourteen-day high-dose esomeprazole, amoxicillin and metronidazole as third-line treatment for<i>Helicobacter pylori</i>infection
Fourteen-day high-dose esomeprazole, amoxicillin and metronidazole as third-line treatment for<i>Helicobacter pylori</i>infection Open
Cure rates of this 14-day schedule using high-dose esomeprazole, amoxicillin and metronidazole as a third-line eradication regimen were suboptimal, especially in patients who had received metronidazole in previous failed eradication regime…
View article: Prevalence of Malnutrition and Nutritional Characteristics of Patients With Inflammatory Bowel Disease
Prevalence of Malnutrition and Nutritional Characteristics of Patients With Inflammatory Bowel Disease Open
The prevalence of malnutrition in inflammatory bowel disease patients was high. We identified some predictive factors of malnutrition. Most of the patients had self-imposed food restrictions, based on their beliefs.
View article: Clinical Outcomes of Golimumab as First, Second or Third Anti-TNF Agent in Patients with Moderate-to-Severe Ulcerative Colitis
Clinical Outcomes of Golimumab as First, Second or Third Anti-TNF Agent in Patients with Moderate-to-Severe Ulcerative Colitis Open
In this real-life cohort of patients with UC, golimumab therapy was effective for inducing and maintaining clinical response. Although anti-TNF-naive patients had better outcomes, golimumab was also effective in anti-TNF-experienced patien…
View article: Evaluation of the Quality of Semen and Sexual Function in Men with Inflammatory Bowel Disease
Evaluation of the Quality of Semen and Sexual Function in Men with Inflammatory Bowel Disease Open
Men with Crohn's disease showed a trend toward poorer semen quality than those with ulcerative colitis. Treatment with anti-tumor necrosis factor drugs does not seem to be associated with poor sperm quality. In patients in clinical remissi…
View article: Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease
Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease Open
The sensitivity of routine TST performed just before starting anti-TNF therapy is low. TST performed at an early stage enables screening in the absence of immunosuppressive treatment and thus maximises the diagnostic yield of TST for detec…
View article: P327 Evolution after a “de-intensification” strategy with anti-TNF therapy in patients with inflammatory bowel disease in clinical remission: multicenter study
P327 Evolution after a “de-intensification” strategy with anti-TNF therapy in patients with inflammatory bowel disease in clinical remission: multicenter study Open
Background: The “de-intensification” of anti-TNF therapy in IBD patients with sustained remission may be considered for cost and safety reasons. Our aims were: 1) to evaluate the risk of relapse after antiTNF “de-intensification” in clinic…
View article: DOP063 Serial tuberculin skin test improves the detection of latent tuberculosis infection in inflammatory bowel disease patients
DOP063 Serial tuberculin skin test improves the detection of latent tuberculosis infection in inflammatory bowel disease patients Open
Background: Despite preventive action, active tuberculosis (TB) still occurs in patients on anti-TNF therapy. Steroids and/or immunosuppressants markedly reduce sensitivity of tuberculin skin test (TST) performed before anti-TNF therapy. T…
View article: P314 Management of perianal disease in patients with Crohn's disease
P314 Management of perianal disease in patients with Crohn's disease Open
Background: Perianal disease (PD) in patients with Crohn's disease (CD) can determine the treatment and it is cause of substantial morbidity. Our aims were to describe the multidisciplinary management of patients with CD and associated PD …
View article: Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease
Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease Open
The incidence rate of psoriasis induced by anti-TNF therapy is higher in women and in smokers/former smokers. In most patients, skin lesions were controlled with topical steroids. More than half of patients switching to another anti-TNF ag…
View article: What is the real-life maintenance mesalazine dose in ulcerative colitis?
What is the real-life maintenance mesalazine dose in ulcerative colitis? Open
Half of our UC patients take high MSZ doses (≥ 3 g/d) as maintenance therapy, with acceptable safety and good adherence. Half of all patients take a single daily dose, and one third needed a different commercial brand during therapy. Optin…