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View article: Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer
Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer Open
sTILs, LVI and fibrotic focus provide independent prognostic information in young women with node-negative eTNBC. Our results are of importance for the selection of patients for de-escalation and escalation trials.
View article: OSNA Total Tumor Load for the Prediction of Axillary Involvement in Breast Cancer Patients: Should We use Different Thresholds According to the Intrinsic Molecular Subtype? MOTTO Study
OSNA Total Tumor Load for the Prediction of Axillary Involvement in Breast Cancer Patients: Should We use Different Thresholds According to the Intrinsic Molecular Subtype? MOTTO Study Open
Aims: To assess the impact of the molecular subtype (MS) on the total number of CK19 mRNA copies in all positive SLN (TTL) threshold, to predict non-SLN affectation, and to compare 5 years progression-free survival (PFS) according to the r…
View article: Prognostic Value of Stromal Tumor-Infiltrating Lymphocytes in Young, Node-Negative, Triple-Negative Breast Cancer Patients Who Did Not Receive (neo)Adjuvant Systemic Therapy
Prognostic Value of Stromal Tumor-Infiltrating Lymphocytes in Young, Node-Negative, Triple-Negative Breast Cancer Patients Who Did Not Receive (neo)Adjuvant Systemic Therapy Open
PURPOSE Triple-negative breast cancer (TNBC) is considered aggressive, and therefore, virtually all young patients with TNBC receive (neo)adjuvant chemotherapy. Increased stromal tumor-infiltrating lymphocytes (sTILs) have been associated …
View article: Cardiac Metastasis From Solid Cancers: A 35-Year Single-Center Autopsy Study
Cardiac Metastasis From Solid Cancers: A 35-Year Single-Center Autopsy Study Open
Context.— Cardiac metastases are more prevalent than primary cardiac tumors, and although rare, the incidence is anticipated to increase with the extended survival of oncology patients. Objective.— To estimate the current incidence of card…
View article: BREAST PLASMACYTOMA: A CASE TREATED WITH IRRADIATION THAT EVOLVED TO FURTHER BILATERAL BREAST INVOLVEMENT AND SYSTEMIC DISEASE REFRACTORY TO CHEMOTHERAPY
BREAST PLASMACYTOMA: A CASE TREATED WITH IRRADIATION THAT EVOLVED TO FURTHER BILATERAL BREAST INVOLVEMENT AND SYSTEMIC DISEASE REFRACTORY TO CHEMOTHERAPY Open
Introduction: Plasmacytomas are uncommon malignant lesions in the breast. Further knowledge is needed about the presentation, diagnosis, and therapy of this disease. Case report: A 78-year-old woman had a previous diagnosis of sacral bone …
View article: Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain
Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain Open
The incidence of MCC in Spain is one of the highest in Europe, with a slight predominance in men. The sample has shown that a biopsy is available for diagnosis in most cases. Moreover, the treatment is surgical when the tumour is localized…
View article: Modification of Breast Cancer Milieu with Chemotherapy Plus Dendritic Cell Vaccines: An Approach to Select Best Therapeutic Strategies
Modification of Breast Cancer Milieu with Chemotherapy Plus Dendritic Cell Vaccines: An Approach to Select Best Therapeutic Strategies Open
Purpose: The addition of dendritic cell vaccines (DCV) to neoadjuvant chemotherapy (NAC) could induce immune biomarker changes in those patients with residual disease (RD) by transforming tumor microenvironment. Methods: Core diagnostic bi…
View article: Modification of Breast Cancer Milieu with Chemotherapy Plus Dendritic Cell Vaccines: An Approach to Select Best Therapeutic Strategies
Modification of Breast Cancer Milieu with Chemotherapy Plus Dendritic Cell Vaccines: An Approach to Select Best Therapeutic Strategies Open
BackgroundThe addition of Dendritic cell vaccines (DCV) to neoadjuvant chemotherapy (NAC) could induce immune biomarker changes in those patients with residual disease (RD) by transforming tumor microenvironment.MethodsCore-diagnostic biop…
View article: Modification of Breast Cancer Milieu With Chemotherapy Plus Dendritic Cell Vaccines: An Approach To Select Best Therapeutic Strategies
Modification of Breast Cancer Milieu With Chemotherapy Plus Dendritic Cell Vaccines: An Approach To Select Best Therapeutic Strategies Open
Background The addition of Dendritic cell vaccines (DCV) to neoadjuvant chemotherapy (NAC) could induce immune biomarker changes in those patients with residual disease (RD) by transforming tumor microenvironment. Methods Core-diagnostic b…
View article: ADAM12 is A Potential Therapeutic Target Regulated by Hypomethylation in Triple-Negative Breast Cancer
ADAM12 is A Potential Therapeutic Target Regulated by Hypomethylation in Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and currently lacks any effective targeted therapy. Since epigenetic alterations are a common event in TNBC, DNA methylation profiling can be useful for iden…
View article: Papular eruption characteristic of persistent agmination of lymphomatoid papulosis
Papular eruption characteristic of persistent agmination of lymphomatoid papulosis Open
View article: Tumor size and overall survival in a cohort of young (≤40 years), nodenegative, systemically untreated breast cancer patients; by the PARADIGM study group
Tumor size and overall survival in a cohort of young (≤40 years), nodenegative, systemically untreated breast cancer patients; by the PARADIGM study group Open
View article: Pre-operative management of Pleomorphic and florid lobular carcinoma in situ of the breast: Report of a large multi-institutional series and review of the literature
Pre-operative management of Pleomorphic and florid lobular carcinoma in situ of the breast: Report of a large multi-institutional series and review of the literature Open
View article: PO-387 Differential gene methylation in triple negative breast cancer and non-tumoral mammary tissue
PO-387 Differential gene methylation in triple negative breast cancer and non-tumoral mammary tissue Open
Introduction Breast cancer (BC) is the most frequent neoplasia among women and one of the leading causes of cancer-related death worldwide. It is a clinically heterogeneous disease, with the triple negative (TN) as the most aggressive sub…
View article: Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study
Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study Open
View article: Long-term prognosis of young breast cancer patients (
Long-term prognosis of young breast cancer patients ( Open
View article: Long-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study
Long-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study Open
Introduction Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient’s prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breas…
View article: Is Regression after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Different in Sentinel and Non-sentinel Nodes?
Is Regression after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Different in Sentinel and Non-sentinel Nodes? Open
View article: Role of total tumour load of sentinel lymph node on survival in early breast cancer patients
Role of total tumour load of sentinel lymph node on survival in early breast cancer patients Open
View article: <i>CHL1</i> hypermethylation as a potential biomarker of poor prognosis in breast cancer
<i>CHL1</i> hypermethylation as a potential biomarker of poor prognosis in breast cancer Open
The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation in BC has been exp…
View article: CDH22 hypermethylation is an independent prognostic biomarker in breast cancer
CDH22 hypermethylation is an independent prognostic biomarker in breast cancer Open
View article: Benign Cutaneous Plexiform Hybrid Tumor of Perineurioma and Cellular Neurothekeoma
Benign Cutaneous Plexiform Hybrid Tumor of Perineurioma and Cellular Neurothekeoma Open
View article: Primary anorectal malignant melanoma: an uncommon anorectal pathology
Primary anorectal malignant melanoma: an uncommon anorectal pathology Open
Anorectal malignant melanoma (AMM) is most common primary melanoma of gastrointestinal tract, accounting for 0.05% and 1% of all colorectal and anal cancers. We reported an 85 year-old woman with no significant past medical history who pre…
View article: Mixed adenoneuroendocrine carcinoma (MANEC) of the gastroesophageal junction: a case report and review of the literature
Mixed adenoneuroendocrine carcinoma (MANEC) of the gastroesophageal junction: a case report and review of the literature Open
Esophageal cancer is the fourth most common neoplasm of the gastrointestinal tract. It is responsible for 1.7% of all deaths related with cancer. The two main types of esophageal cancer are squamous cell carcinoma and adenocarcinoma. Other…
View article: Differential involvement of<i>RASSF2</i>hypermethylation in breast cancer subtypes and their prognosis
Differential involvement of<i>RASSF2</i>hypermethylation in breast cancer subtypes and their prognosis Open
Breast cancer is a heterogeneous disease that can be subdivided into clinical, histopathological and molecular subtypes (luminal A-like, luminal B-like/HER2-negative, luminal B-like/HER2-positive, HER2-positive, and triple-negative). The s…
View article: Paradoxical Reaction to Antituberculosis Therapy in a Patient With Lupus Vulgaris
Paradoxical Reaction to Antituberculosis Therapy in a Patient With Lupus Vulgaris Open
Patients receiving treatment for tuberculosis may experience an unexpected deterioration of their disease; this is known as a paradoxical reaction. We present the case of a 59-year-old man with lupus vulgaris who experienced a paradoxical …