Alicia Damm
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View article: Steric repulsion counteracts ER–to–lipid droplet protein movement
Steric repulsion counteracts ER–to–lipid droplet protein movement Open
Lipid droplets (LDs) are organelles with a neutral lipid core surrounded by a phospholipid monolayer, which is continuous with the cytoplasmic leaflet of the endoplasmic reticulum (ER). LD function depends on a highly dynamic LD surface pr…
View article: Steric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement
Steric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement Open
Lipid droplets (LDs) are uniquely shaped organelles consisting of a neutral lipid core surrounded by a phospholipid monolayer, continuous with the cytosolic leaflet of the endoplasmic reticulum (ER). The dynamics and function of LDs are cl…
View article: α/β hydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation
α/β hydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation Open
Lipid droplets (LDs) are the major sites of lipid and energy homeostasis. However, few LD biogenesis proteins have been identified. Using model microalga Chlamydomonas, we show that ABHD1, an α/β-hydrolase domain-containing protein, is loc…
View article: Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature
Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature Open
While mechanosensitive ion channels’ gating has been well documented, the effect of membrane mechanics, in particular membrane curvature, on the function of transporters remains elusive. Since conical shape transmembrane proteins locally d…
View article: The α/β hydrolase domain-containing protein 1 (ABHD1) acts as a lysolipid lipase and is involved in lipid droplet formation
The α/β hydrolase domain-containing protein 1 (ABHD1) acts as a lysolipid lipase and is involved in lipid droplet formation Open
Lipid droplets (LDs) are the major sites of lipid and energy homeostasis. However, few LD biogenesis proteins have been identified. Here, using Chlamydomonas as a model, we show that ABHD1, a member of the α/β hydrolase domain-containing p…
View article: Interplay between the conformational dynamics of a transmembrane protein and the mechanical properties of its surrounding membrane
Interplay between the conformational dynamics of a transmembrane protein and the mechanical properties of its surrounding membrane Open
Cell membranes are composed of a lipid bilayer, crowded with transmembrane proteins that mediate nearly all of the membrane functions, such as detoxification and communication. There is a tight interaction between lipids and transmembrane …
View article: Interplay between the Conformational Dynamics of a Bacterial ABC-Transporter and Surrounding Membrane Mechanical Properties
Interplay between the Conformational Dynamics of a Bacterial ABC-Transporter and Surrounding Membrane Mechanical Properties Open
View article: Functional and Structural Studies of Interplay between an ABC Transporter and its Surrounding Membrane Environment
Functional and Structural Studies of Interplay between an ABC Transporter and its Surrounding Membrane Environment Open