Explanipedia

The association of Life’s Essential 8 with risk of stroke: The EPIC-NL prospective cohort study Open

Merve Spronk, Yvonne T. van der Schouw, F Te Hoonte, W. M. Monique Verschuren, Michiel L Bots , et al. · 2025

Our data suggest a strong inverse relationship between LE8 and total, ischemic and hemorrhagic stroke among Dutch adults. Improving the LE8 score could be a valuable tool to aid in stroke prevention.

Comparing Life’s Simple 7 and Life’s Essential 8 With Risk of Heart Failure Open

Inge G van Loon, Yvonne T. van der Schouw, M. Louis Handoko, W. M. Monique Verschuren, Alicia Uijl · 2025

Proteomics-based clustering outperforms clinical clustering in identifying heart failure patient groups with distinct outcomes Open

Marion van Vugt, Ruicong She, Isabella Kardys, Teun B. Petersen, Marie de Bakker , et al. · 2025

Background. Clustering of heart failure (HF) patients typically relies on clinical characteristics, which may not reflect underlying pathophysiology relevant for personalised medicine. We aimed to identify plasma protein profiles of HF pat…

Koppeling van kwaliteitsregistraties en CBS-microdata in de zorg: mogelijkheden, uitdagingen en aanbevelingen Open

Daniëlle J. M. Koornneef, Sylvia Brinkman, Nicolette F. de Keizer, Saskia Houterman, M. Nielen , et al. · 2025

Interpretable phenotyping of Heart Failure patients with Dutch discharge letters Open

Valter Torri, Machteld Boonstra, Mariëlle C. van de Veerdonk, Deborah N. Kalkman, Alicia Uijl , et al. · 2025

Objective: Heart failure (HF) patients present with diverse phenotypes affecting treatment and prognosis. This study evaluates models for phenotyping HF patients based on left ventricular ejection fraction (LVEF) classes, using structured …

Uptitration of statin therapy in women and men: a population-based cohort study Open

Pauline Kiss, Alicia Uijl, Diederick E. Grobbee, Monika Hollander, Elisabeth Smits , et al. · 2025

Aims Statins are widely used for the prevention and management of cardiovascular disease (CVD). Women have been shown to be less likely to receive guideline-recommended dose of statins and reach target lipid levels. This study aims to exam…

Sex Differences in Acute Coronary Syndromes: A Scoping Review Across the Care Continuum Open

A Marza Florensa, Pauline Kiss, Dina Mohamed Youssef, Sara Jalali-Farahani, Fernando Laņas , et al. · 2025

Introduction: Optimal diagnosis and management of acute coronary syndrome (ACS) is essential to improve clinical outcomes and prognosis. Sex disparities in ACS care have been reported in the literature, but evidence gaps remain. This revie…

Federated learning as a smart tool for research on infectious diseases Open

Laura C. Zwiers, Diederick E. Grobbee, Alicia Uijl, David S. Y. Ong · 2024

Simplification of a registry-based algorithm for ejection fraction prediction in heart failure patients: Applicability in cardiology centres of the Netherlands Open

Elisa Dal Canto, Alicia Uijl, N. Charlotte Onland‐Moret, Sophie H. Bots, Leonard Hofstra , et al. · 2024

Background Left ventricular ejection fraction (EF) is used to categorize heart failure (HF) into phenotypes but this information is often missing in electronic health records or non-HF registries. Methods We tested the applicability of a s…

Unravelling sex disparities in statin dose titration patterns in primary care Open

Pauline Kiss, Alicia Uijl, Tessa C X Duk, D.E. Grobbee, Monika Hollander , et al. · 2024

Introduction Statins are widely recommended by clinical guidelines for the prevention and management of cardiovascular disease. While guidelines make no sex-specific recommendations, studies have shown that women are less likely than men t…

Increased risk of atrial fibrillation with low cardiovascular health: life essential 8 in a dutch population Open

F Te Hoonte, Yvonne T. van der Schouw, Merve Spronk, Jolanda M.A. Boer, W. M. Monique Verschuren , et al. · 2024

Introduction The American Heart Association (AHA) introduced the concept of Life’s Essential 8 (LE8) to measure and monitor cardiovascular health (CVH) to prevent cardiovascular diseases. Purpose This study examined the association between…

Life essential 8 associated with a lower risk of stroke: ideal cardiovascular health in the EPIC-NL prospective cohort study Open

Merve Spronk, Yvonne T. van der Schouw, F Te Hoonte, Jolanda M.A. Boer, W. M. Monique Verschuren , et al. · 2024

Introduction The American Heart Association (AHA) introduced the concept of Life’s Essential 8 (LE8) to measure and monitor cardiovascular health (CVH) to prevent cardiovascular diseases. Purpose This study aims to identify the association…

Sex differences in the prognostic role of achieving target doses of heart failure medications: Data from the Swedish Heart Failure Registry Open

Amerigo Ferrari, Davide Stolfo, Alicia Uijl, Nicola Orsini, Lina Benson , et al. · 2024

Aims Guidelines recommend target doses (TD) of heart failure (HF) with reduced ejection fraction (HFrEF) medications regardless of sex. Differences in pharmacokinetics and pharmacodynamics may explain heterogeneity in treatment response, a…

#614 Identifying distinct patient phenotypes in patients with chronic kidney disease Open

Julia M.T. Colombijn, Alicia Uijl, Lotte Kaasenbrood, Saskia Haitjema, Michiel L. Bots , et al. · 2024

Background and Aims Patients with chronic kidney disease (CKD) are heterogeneous in terms of age, causes of CKD, and comorbidities. Although individual risk factors greatly influence patients’ risk of clinical outcomes, this heterogeneity …

Sex Differences in the Primary Prevention of Cardiovascular Diseases in a Dutch Primary Care Setting Open

Pauline Kiss, Alicia Uijl, Estefania Betancur, Annemarijn R de Boer, Diederick E. Grobbee , et al. · 2024

Background: Sex differences in the primary prevention of cardiovascular diseases (CVD) have been shown, but the evidence is mixed and fragmented. In this study, we assessed sex differences in cardiovascular risk factors assessment, risk fa…

Embedding routine health care data in clinical trials: with great power comes great responsibility Open

M. Louis Handoko, Frances S. de Man, Jasper J. Brugts, Peter van der Meer, Hanneke Rhodius‐Meester , et al. · 2024

Ideal cardiovascular health and cardiovascular-related events: a systematic review and meta-analysis Open

F Te Hoonte, Merve Spronk, Qi Sun, Kangrui Wu, Shiqi Fan , et al. · 2023

Aims The aim of this study was to systematically review and quantitatively summarize the evidence on the association between Life Simple’s 7 (LS7) and multiple cardiovascular diseases (CVDs) and cardiometabolic diseases (CMDs). Methods and…

Multimorbidity in Heart Failure: Leveraging Cluster Analysis to Guide Tailored Treatment Strategies Open

Mariëlle C. van de Veerdonk, Gianluigi Savarese, M. Louis Handoko, Joline W. J. Beulens, Folkert W. Asselbergs , et al. · 2023

Does Heterogeneity Exist in Treatment Associations With Renin–Angiotensin–System Inhibitors or Beta-blockers According to Phenotype Clusters in Heart Failure with Preserved Ejection Fraction? Open

Alicia Uijl, Stefan Koudstaal, Davide Stolfo, Ulf Dahlström, Ilonca Vaartjes , et al. · 2023

Discovering Distinct Phenotypical Clusters in Heart Failure Across the Ejection Fraction Spectrum: a Systematic Review Open

Claartje M.E.M. Meijs, M. Louis Handoko, Gianluigi Savarese, Robin W.M. Vernooij, Ilonca Vaartjes , et al. · 2023

Review Purpose This systematic review aims to summarise clustering studies in heart failure (HF) and guide future clinical trial design and implementation in routine clinical practice. Findings 34 studies were identified ( n = 19 in HF wit…

Identifying distinct clinical clusters in heart failure with mildly reduced ejection fraction Open

Claartje M.E.M. Meijs, Jasper J. Brugts, Lars H. Lund, Gerard C.M. Linssen, Hans‐Peter Brunner‐La Rocca , et al. · 2023

We found robust clusters with potential clinical meaning and differences in mortality and hospitalisation. Our clustering model could be valuable as a clinical differentiation support and prognostic tool in clinical trial design.

Sex differences in the generalizability of randomized clinical trials in heart failure with reduced ejection fraction Open

Megan Schroeder, Yvonne Mei Fong Lim, Gianluigi Savarese, Kiliana Suzart‐Woischnik, Claire Baudier , et al. · 2023

Aims In order to understand how sex differences impact the generalizability of randomized clinical trials (RCTs) in patients with heart failure (HF) and reduced ejection fraction (HFrEF), we sought to compare clinical characteristics and c…

Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis Open

Maria A. de Winter, Alicia Uijl, Harry R. Büller, Marc Carrier, Alexander T. Cohen , et al. · 2023

Biomarker changes as surrogate endpoints in early‐phase trials in heart failure with reduced ejection fraction Open

Gianluigi Savarese, Alicia Uijl, Wouter Ouwerkerk, Jasper Tromp, Stefan D. Anker , et al. · 2022

Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early‐phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent morbidity/mortali…

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology Open

Massimo Piepoli, Marianna Adamo, Andrea Barison, Reinaldo B. Bestetti, Jan Biegus , et al. · 2022

The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present position paper aims to p…

Generalizability of randomized controlled trials in heart failure with reduced ejection fraction Open

Yvonne Mei Fong Lim, Megan Molnar, Ilonca Vaartjes, Gianluigi Savarese, Marinus J.C. Eijkemans , et al. · 2021

Background Heart failure (HF) trials have stringent inclusion and exclusion criteria, but limited data exist regarding generalizability of trials. We compared patient characteristics and outcomes between patients with HF and reduced ejecti…

Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries Open

Marijke Linschoten, Alicia Uijl, Astrid Schut, C E M Jakob, L R Romão , et al. · 2021

Aims Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and i…

Cardiac resynchronization therapy with or without defibrillator in patients with heart failure Open

Benedikt Schrage, Lars H. Lund, Michael Melin, Lina Benson, Alicia Uijl , et al. · 2021

Aims Randomized data on the efficacy/safety of cardiac resynchronization therapy with vs. without defibrillator (CRT-D,-P) in heart failure with reduced ejection fraction (HFrEF) are scarce. We aimed to evaluate survival associated with us…

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology Open

Massimo Piepoli, Marianna Adamo, Andrea Barison, Reinaldo B. Bestetti, Jan Biegus , et al. · 2021

The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present consensus document aims …

Empagliflozin in Heart Failure With Predicted Preserved Versus Reduced Ejection Fraction: Data From the EMPA-REG OUTCOME Trial Open

Gianluigi Savarese, Alicia Uijl, Lars H. Lund, Stefan D. Anker, Folkert W. Asselbergs , et al. · 2021

In EMPA-REG OUTCOME, one-third of the patients with HF had predicted HFpEF. The benefits of empagliflozin on HF and mortality outcomes were consistent in nonHF, predicted HFpEF and HFmrEF/HFrEF.

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