Alina Brüge
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View article: Targeting the serotonergic system in the treatment of neurodegenerative diseases—emerging therapies and unmet challenges
Targeting the serotonergic system in the treatment of neurodegenerative diseases—emerging therapies and unmet challenges Open
More than 65 million people worldwide experience neurodegenerative diseases, such as Alzheimer disease, frontotemporal dementia, Parkinson disease, and amyotrophic lateral sclerosis. As the risk of developing these diseases increases with …
View article: Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R Open
Background Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the microtubule-associated protein Tau leads to the development of so-called tauopathies characterized by the …
View article: Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies
Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies Open
INTRODUCTION Hyperphosphorylation and aggregation of the microtubule‐associated protein tau cause the development of tauopathies, such as Alzheimer's disease and frontotemporal dementia (FTD). We recently uncovered a causal link between co…