Alina Efremenko
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View article: Impact of gene selection criteria on transcriptomic ontology-based point of departure estimates
Impact of gene selection criteria on transcriptomic ontology-based point of departure estimates Open
Apical effects are typically associated with changes in gene expression, which allows for the use of short- term in life transcriptomic studies to derive biologically relevant points of departure (POD). These methods offer cost savings ove…
View article: Assessing the basal gene expression of cancer cell lines for in vitro transcriptomic toxicology screening
Assessing the basal gene expression of cancer cell lines for in vitro transcriptomic toxicology screening Open
In vitro toxicology has used immortalized cancer cell lines as model human systems for decades. However, these cell lines pose problems in designing toxicity testing programs as they inherently do not represent normal human biology. There …
View article: Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology
Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology Open
There is increasing interest in using modern 'omics technologies, such as whole transcriptome sequencing, to inform decisions about human health safety and chemical toxicity hazard. High throughput methodologies using in vitro assays offer…
View article: New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine Open
This case study on the model substance caffeine demonstrates the viability of a 10-step read-across (RAX) framework in practice. New approach methodologies (NAM), including RAX and physiologically-based kinetic (PBK) modelling were used to…
View article: Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future
Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future Open
The Threshold of Toxicological Concern (TTC) is a risk assessment tool for evaluating low-level exposure to chemicals with limited toxicological data. A next step in the ongoing development of TTC is to extend this concept further so that …
View article: The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations
The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations Open
Computational technologies hold promise for informing decisions on the use of thousands of chemicals in commerce that have little or no toxicological data. Threshold of Toxicological Concern (TTC) groups compounds based on the outcome of a…
View article: Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids
Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids Open
The assessment of potentially sensitive populations is an important application of risk assessment. To address the concern for age-related sensitivity to pyrethroid insecticides, life-stage physiologically based pharmacokinetic (PBPK) mode…
View article: Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans Open
To address concerns around age-related sensitivity to pyrethroids, a life-stage physiologically based pharmacokinetic (PBPK) model, supported by in vitro to in vivo extrapolation (IVIVE) was developed. The model was used to predict age-dep…
View article: Updating physiologically based pharmacokinetic models for manganese by incorporating rapid association/dissociation processes in tissues
Updating physiologically based pharmacokinetic models for manganese by incorporating rapid association/dissociation processes in tissues Open
Previously, we developed a series of physiologically based pharmacokinetic (PBPK) models for manganese (Mn) in which saturable tissue binding and dose-dependent increases in biliary excretion captured key aspects of Mn homeostasis biology.…
View article: An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis
An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis Open
Rising obesity rates worldwide have socio-economic ramifications. While genetics, diet, and lack of exercise are major contributors to obesity, environmental factors may enhance susceptibility through disruption of hormone homeostasis and …
View article: Time‐ and concentration‐dependent genomic responses of the rat airway to inhaled nickel sulfate
Time‐ and concentration‐dependent genomic responses of the rat airway to inhaled nickel sulfate Open
While insoluble nickel subsulfide (Ni 3 S 2 ) was carcinogenic in the lung in a 2‐year rat bioassay, soluble nickel sulfate hexahydrate (NiSO 4* 6H 2 O) was not. To investigate whether differences in the cellular responses to these two nic…