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View article: Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion
Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion Open
Breast cancer cells invade mammary adipose tissue during initial stages of metastasis but how the physical properties of adipose tissue regulate this process remains unclear. Here, we combined single cell mechanical characterization of pri…
View article: Coxiella burnetii infects osteoclasts and alters their differentiation and function in a type IV secretion system-dependent manner
Coxiella burnetii infects osteoclasts and alters their differentiation and function in a type IV secretion system-dependent manner Open
Chronic Q fever is caused by persistent infection with the Gram-negative bacterium Coxiella burnetii. The mechanisms underlying this persistence remain elusive, but the presence of the bacteria in the bone marrow of C. burnetii-infected pa…
View article: Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow
Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow Open
Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary to a recent report 1 suggesting skull m…
View article: Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response
Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response Open
Leishmania (L.) mexicana -induced cutaneous leishmaniasis (CL) is a neglected tropical disease characterized by localized chronic ulcers (LCL) and, in rare cases, by disseminated skin lesions (DCL). The therapeutic options for CL are curre…
View article: A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis
A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis Open
Rheumatoid arthritis (RA) and other inflammatory arthritis are systemic diseases that primarily affect the joints, characterized by synovial inflammation and progressive cartilage and bone degradation. The temporomandibular joint (TMJ) is …
View article: Effects of different B-cell-depleting strategies on the lymphatic tissue
Effects of different B-cell-depleting strategies on the lymphatic tissue Open
Protein-based B cell depletion reduces but usually does not deplete B cells in lymph nodes leaving the follicular architecture intact and being associated with disease recurrence.
View article: Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus
Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus Open
CD19-CAR T cell therapy induces substantial suppression of key immunological pathways involved in SLE, including complement activation and type I interferon responses, accompanied by a metabolic reprogramming. Molecular profiles of remissi…
View article: DISTINCT MOLECULAR PROFILES OF REMISSION POST-CD19 CAR-T CELL THERAPY VERSUS STANDARD IMMUNOSUPPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS
DISTINCT MOLECULAR PROFILES OF REMISSION POST-CD19 CAR-T CELL THERAPY VERSUS STANDARD IMMUNOSUPPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS Open
O006 / #412 Topic: AS12 - Genetics, Epigenetics, Transcriptomics SCIENTIFIC HYBRID SESSION: CLINICAL TRACK PRESENTATIONS - OUTSTANDING ABSTRACT PRESENTATIONS 23-05-2025 9:00 AM - 10:00 AM Background/Purpose Remission, as defined by the Def…
View article: Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation Open
Germinal centers where B cells undergo clonal expansion and antibody affinity maturation are hypoxic microenvironments. However, the function of hypoxia-inducible factor (HIF)-1α in immunoglobulin production remains incompletely characteri…
View article: CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series
CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series Open
Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, ELAN-Foundation Erlangen, IZKF Erlangen, and Bundesministerium für Bildung und Forschung.
View article: Mutual Amplification of <scp>GLI2</scp>/Hedgehog and Transcription Factor <scp>JUN</scp>/<scp>AP</scp>‐1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies
Mutual Amplification of <span>GLI2</span>/Hedgehog and Transcription Factor <span>JUN</span>/<span>AP</span>‐1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies Open
Objective Deregulation of the cJUN/AP‐1 and hedgehog/GLI2 signaling pathways has been implicated in fibroblast activation in systemic sclerosis (SSc). However, the consequences of their concomitant up‐regulation are unknown. Here, we teste…
View article: Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis Open
Acod1 and itaconate are crucial regulators of osteoclast differentiation and bone loss in inflammatory arthritis.
View article: Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE
Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE Open
Applying advanced molecular profiling together with highly specific targeted therapies offers the possibility to better dissect the mechanisms underlying immune-mediated inflammatory diseases such as systemic lupus erythematosus (SLE) in h…
View article: Osteocytes support bone metastasis of melanoma cells by CXCL5
Osteocytes support bone metastasis of melanoma cells by CXCL5 Open
Bone metastasis is a common complication of certain cancers such as melanoma. The spreading of cancer cells into the bone is supported by changes in the bone marrow environment. The specific role of osteocytes in this process is yet to be …
View article: Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery Open
Our results identify IEC necroptosis as a critical link between the gut and the development of arthritis.
View article: <scp>CD19</scp> Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus
<span>CD19</span> Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus Open
B cell generation of autoantibodies is a crucial step in the pathogenesis of systemic lupus erythematosus (SLE). After their differentiation in the bone marrow, B cells populate the secondary lymphatic organs, where they undergo further ma…
View article: Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity
Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity Open
Obesity is characterized by the expansion of the adipose tissue, usually accompanied by inflammation, with a prominent role of macrophages infiltrating the visceral adipose tissue (VAT). This chronic inflammation is a major driver of obesi…
View article: Alteration of Gut Microbiota in Individuals at <scp>High‐Risk</scp> for Rheumatoid Arthritis Associated With Disturbed Metabolome and the Initiation of Arthritis Through the Triggering of Mucosal Immunity Imbalance
Alteration of Gut Microbiota in Individuals at <span>High‐Risk</span> for Rheumatoid Arthritis Associated With Disturbed Metabolome and the Initiation of Arthritis Through the Triggering of Mucosal Immunity Imbalance Open
Objective In this study, we aimed to decipher the gut microbiome (GM) and serum metabolic characteristic of individuals at high risk for rheumatoid arthritis (RA) and to investigate the causative effect of GM on the mucosal immune system a…
View article: Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma
Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma Open
Introduction: Increasing evidences have shown that hypoxia and the immune microenvironment play vital roles in the development of osteosarcoma. However, reliable gene signatures based on the combination of hypoxia and the immune status for…
View article: A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens
A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens Open
Autoimmune diseases (AIDs) are caused by the loss of self-tolerance and destruction of tissues by the host's immune system. Several antigen-specific immunotherapies, focused on arresting the autoimmune attack, have been tested in clinical …