Aline G. Santana
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View article: #691 Histological changes and a3ß1 integrin and MMP-1 expressions in early Fabry nephropathy in female patients
#691 Histological changes and a3ß1 integrin and MMP-1 expressions in early Fabry nephropathy in female patients Open
Background and Aims Fabry nephropathy (FN), characterized by proteinuira and progressive loss of renal function, may lead to ESKD and, consequently, to significant morbidity and mortality. Due to the skewed X inactivation, Fabry manifestat…
View article: Agonistas de GLP-1 e GLP-1/GIP no tratamento da obesidade: impacto na preservação de massa magra e risco de sarcopenia
Agonistas de GLP-1 e GLP-1/GIP no tratamento da obesidade: impacto na preservação de massa magra e risco de sarcopenia Open
A obesidade representa um grave problema de saúde pública mundial, e o uso de agonistas de GLP-1 e GLP-1/GIP tem se destacado como estratégia terapêutica eficaz para o controle de peso em adultos com sobrepeso ou obesidade. Contudo, surgem…
View article: Canine Diabetes Mellitus: Advances, Challenges, and Insights from the Literature
Canine Diabetes Mellitus: Advances, Challenges, and Insights from the Literature Open
Diabetes mellitus is a multifactorial and complex endocrinopathy, characterized by an increase in blood glucose levels, involving a heterogeneous group with metabolic changes in carbohydrates, fats and proteins, resulting in the inability …
View article: Noninvasive and Sensitive Biosensor for the Detection of Oral Cancer Prognostic Biomarkers
Noninvasive and Sensitive Biosensor for the Detection of Oral Cancer Prognostic Biomarkers Open
Early detection of oral squamous cell carcinoma (OSCC) significantly enhances treatment outcomes and survival rates, with lymph node metastasis serving as a main prognostic factor. However, current clinical practices rely on TNM classifica…
View article: Caffeine: impact on energy metabolism and obesity treatment
Caffeine: impact on energy metabolism and obesity treatment Open
Caffeine has a significant impact on energy metabolism, primarily by increasing thermogenesis, lipolysis, and fat oxidation. This can offer benefits for obesity treatment, supporting weight loss and appetite control. The objective of this …
View article: Viabilidade dos principais métodos de imagem no diagnóstico de pneumonia
Viabilidade dos principais métodos de imagem no diagnóstico de pneumonia Open
Objetivo: analisar a viabilidade dos principais métodos de imagem no diagnóstico de pneumonia. Métodos: Uma revisão integrativa da literatura, que ocorreu em abril no ano de 2025 e utilizou a estratégia PICO, sendo paciente (P), intervençã…
View article: Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity
Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity Open
Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardiovascular disease. Endothelial dysfunction is an early predictor of obesity. However, little is known regarding how e…
View article: c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation
c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation Open
Background: Intra-amniotic inflammation (IAI) is associated with increased risk of preterm birth and bronchopulmonary dysplasia (BPD), but the mechanisms by which IAI leads to preterm birth and BPD are poorly understood, and there are no e…
View article: ZIF-8 Metal–Organic Framework Electrochemical Biosensor for the Detection of Protein–Protein Interaction
ZIF-8 Metal–Organic Framework Electrochemical Biosensor for the Detection of Protein–Protein Interaction Open
Made available in DSpace on 2021-06-25T10:24:10Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021-02-23
View article: ADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
ADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity Open
View article: Front Cover: Ion Mobility‐Enhanced Data‐Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes
Front Cover: Ion Mobility‐Enhanced Data‐Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes Open
DOI: 10.1002/pmic.201700209 The cover shows a 2D ion mobility map, composed by drift time x m/z. In article number 1700209, Juliana S. Cassoli et al. used ion mobility-enhanced, data-independent acquisitions and 2D-nanoUPLC fractionation t…
View article: O papel do proteoma nuclear da substância branca e cinzenta de cérebros de pacientes com esquizofrenia
O papel do proteoma nuclear da substância branca e cinzenta de cérebros de pacientes com esquizofrenia Open
Schizophrenia is a serious neuropsychiatric disorder that manifests through several symptoms from young adulthood on and its treatment is among the most expensive across all diseases.In contrast to its high prevalence and severity, little …
View article: Supplementary Material for: The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains
Supplementary Material for: The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains Open
Schizophrenia (SCZ) is a serious neuropsychiatric disorder that manifests through several symptoms from early adulthood. Numerous studies over the last decades have led to significant advances in increasing our understanding of the factors…
View article: O papel do proteoma nuclear da substância branca e cinzenta de cérebros de pacientes com esquizofrenia = The role of the nuclear proteome from the white and gray matter of schizophrenia brains
O papel do proteoma nuclear da substância branca e cinzenta de cérebros de pacientes com esquizofrenia = The role of the nuclear proteome from the white and gray matter of schizophrenia brains Open
View article: The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains
The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains Open
Schizophrenia (SCZ) is a serious neuropsychiatric disorder that manifests through several symptoms from early adulthood. Numerous studies over the last decades have led to significant advances in increasing our understanding of the factors…
View article: Front cover: Proteomics and molecular tools for unveiling missing links in the biochemical understanding of schizophrenia
Front cover: Proteomics and molecular tools for unveiling missing links in the biochemical understanding of schizophrenia Open
DOI: 10.1002/prca.201600021 The cover picture illustrates the missing links in schizophrenia research. Further details can be found in the article by Juliana M. Nascimento et al. on page 1148.
View article: Identificação de possíveis alvos dos polissacarídeos sulfatados sobre a cascata de coagulação e análises in silico das interações
Identificação de possíveis alvos dos polissacarídeos sulfatados sobre a cascata de coagulação e análises in silico das interações Open