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View article: Potentiation of combined p19Arf and interferon-beta cancer gene therapy through its association with doxorubicin chemotherapy
Potentiation of combined p19Arf and interferon-beta cancer gene therapy through its association with doxorubicin chemotherapy Open
View article: miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients
miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients Open
View article: Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death
Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death Open
While treatments for colorectal cancer continue to improve, some 50% of patients succumb within 5 years, pointing to the need for additional therapeutic options. We have developed a modified non-replicating adenoviral vector for gene trans…
View article: Response of human melanoma cell lines to interferon-beta gene transfer mediated by a modified adenoviral vector
Response of human melanoma cell lines to interferon-beta gene transfer mediated by a modified adenoviral vector Open
View article: p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro
p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro Open
The immune stimulatory and anti-neoplastic functions of type I interferon have long been applied for the treatment of melanoma. However, the systemic application of high levels of this recombinant protein is often met with toxicity. An app…
View article: p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro
p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro Open
The immune stimulatory and anti-neoplastic functions of type I interferon have long been applied for the treatment of melanoma. However, the systemic application of high levels of this recombinant protein is often met with toxicity. An app…
View article: Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy
Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy Open
During the last decades, the pleiotropic antitumor functions exerted by type I interferons (IFNs) have become universally acknowledged, especially their role in mediating interactions between the tumor and the immune system. Indeed, type I…
View article: Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death Open
Simultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unlea…
View article: Harnessing combined p19Arf and interferon-beta gene transfer as an inducer of immunogenic cell death and mediator of cancer immunotherapy
Harnessing combined p19Arf and interferon-beta gene transfer as an inducer of immunogenic cell death and mediator of cancer immunotherapy Open
Harnessing combined p19Arf and interferon-beta gene transfer as an inducer of immunogenic cell death and mediator of cancer immunotherapy
View article: Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma
Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma Open
High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and β1 integrin, inducing PI3-kinase pathway and cell survival. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), generated under phosphatidyli…
View article: Reestablishment of p53/Arf and interferon-β pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death
Reestablishment of p53/Arf and interferon-β pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death Open
View article: Induction of Oxidants Distinguishes Susceptibility of Prostate Carcinoma Cell Lines to p53 Gene Transfer Mediated by an Improved Adenoviral Vector
Induction of Oxidants Distinguishes Susceptibility of Prostate Carcinoma Cell Lines to p53 Gene Transfer Mediated by an Improved Adenoviral Vector Open
Previously, the authors developed an adenoviral vector, Ad-PG, where transgene expression is regulated by a p53-responsive promoter. When used to transfer the p53 cDNA, a positive feedback mechanism is established. In the present study, a …
View article: Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma
Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma Open
View article: Avaliação dos mecanismos moleculares das vias de p53/ARF e IFNbeta envolvidos com a resposta de células de melanoma ao tratamento com os transgenes p19Arf e IFNbeta
Avaliação dos mecanismos moleculares das vias de p53/ARF e IFNbeta envolvidos com a resposta de células de melanoma ao tratamento com os transgenes p19Arf e IFNbeta Open
\n O melanoma é uma forma de câncer com alto índice de morte devido, em parte, à sua tendência de formar metástases. Esse tipo tumoral apresenta deleção de CDKN2A e amplificação de HDM2 em aproximadamente 50 % dos casos, mas apenas 10 % ap…
View article: Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy
Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy Open