Artur Paiva
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View article: Systemic Immune Profiling Reveals Candidate Biomarkers in Luminal A Breast Cancer: A Comparative Pilot Study
Systemic Immune Profiling Reveals Candidate Biomarkers in Luminal A Breast Cancer: A Comparative Pilot Study Open
Background: Luminal A breast cancer, the most common molecular subtype, is typically associated with a favorable prognosis. However, its systemic immune landscape remains largely uncharacterized. Methods: In this study, we used high-dimens…
View article: Immune monitoring of neoadjuvant chemo-immunotherapy for triple-negative breast cancer
Immune monitoring of neoadjuvant chemo-immunotherapy for triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor, progesterone receptor, and HER2 expression. It accounts for 10–20% of breast cancer cases, predominantly affecting younger women, an…
View article: Multiple Myeloma Laboratory Diagnostics Made Simple: Practical Insights and Key Recommendations
Multiple Myeloma Laboratory Diagnostics Made Simple: Practical Insights and Key Recommendations Open
Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease…
View article: Exploring the G-Quadruplex Formation of AS1411 Derivatives
Exploring the G-Quadruplex Formation of AS1411 Derivatives Open
AS1411 is a G-quadruplex (G4) aptamer that binds tightly to nucleolin (NCL) on the cell surface and has shown strong anticancer effects. However, this aptamer is highly polymorphic, presenting different types of G4s, which may hinder its p…
View article: Breast Cancer and Tumor Microenvironment: The Crucial Role of Immune Cells
Breast Cancer and Tumor Microenvironment: The Crucial Role of Immune Cells Open
Breast cancer is the most common type of cancer in women and the second leading cause of death by cancer. Despite recent advances, the mortality rate remains high, underlining the need to develop new therapeutic approaches. The complex int…
View article: Early-Stage Luminal B-like Breast Cancer Exhibits a More Immunosuppressive Tumor Microenvironment than Luminal A-like Breast Cancer
Early-Stage Luminal B-like Breast Cancer Exhibits a More Immunosuppressive Tumor Microenvironment than Luminal A-like Breast Cancer Open
Background: Breast cancer is a heterogeneous malignant disease with a varying prognosis and is classified into four molecular subtypes. It remains one of the most prevalent cancers globally, with the tumor microenvironment playing a critic…
View article: Unmasking the lipid landscape: carbamazepine induces alterations in Leydig cell lipidome
Unmasking the lipid landscape: carbamazepine induces alterations in Leydig cell lipidome Open
Leydig cells rely on lipids and fatty acids (FA) for essential functions like maintaining structural integrity, energy metabolism, and steroid hormone synthesis, including testosterone production.
View article: High percentage of immune Th1 and Tc1 cells infiltrating visceral adipose tissue in people with obesity
High percentage of immune Th1 and Tc1 cells infiltrating visceral adipose tissue in people with obesity Open
Subcutaneous (SAT) and visceral (VAT) adipose tissue dysfunction during the obesity onset can lead to increased expression of inflammatory molecules, and consequently to immune cell infiltration. The aim was to deeply characterize the T ce…
View article: Risk factors for COVID-19 among healthcare workers: a hospital-based cohort study in Portugal
Risk factors for COVID-19 among healthcare workers: a hospital-based cohort study in Portugal Open
Background Healthcare workers (HCWs) have an increased risk of transmitting SARS-CoV-2 infection to frail patients and are also at higher risk of exposure. Hence, it is essential to understand the risk factors for infection of HCWs to limi…
View article: Tumor Resection in Hepatic Carcinomas Restores Circulating T Regulatory Cells
Tumor Resection in Hepatic Carcinomas Restores Circulating T Regulatory Cells Open
Background/Objectives: Cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) represent major primary liver cancers, affecting one of the most vital organs in the human body. T regulatory (Treg) cells play an important role in liver c…
View article: Impaired Periodontitis-Induced Cytokine Production by Peripheral Blood Monocytes and Myeloid Dendritic Cells in Patients with Rheumatoid Arthritis: A Case–Control Study
Impaired Periodontitis-Induced Cytokine Production by Peripheral Blood Monocytes and Myeloid Dendritic Cells in Patients with Rheumatoid Arthritis: A Case–Control Study Open
Background: Immune cells from rheumatoid arthritis (RA) patients display a reduced in vitro response to Porphyromonas gingivalis (P. gingivalis), which may have functional immune consequences. The aim of this study was to characterize, by …
View article: Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression
Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression Open
Hepatitis B, caused by the hepatitis B virus (HBV), often progresses to chronic infection, leading to severe complications, such as cirrhosis, liver failure, and hepatocellular carcinoma. Chronic HBV infection is characterized by a complex…
View article: Pulse pressure amplification as a predictor of cardiovascular risk in shift workers: an analysis based on PARTAGE
Pulse pressure amplification as a predictor of cardiovascular risk in shift workers: an analysis based on PARTAGE Open
Background/Introduction Shift workers are known to have a higher risk of cardiovascular diseases, however there is no precise description of the etiology of these problems. One of the hypotheses refers to the increase in blood pressure due…
View article: Influence of Aldehyde Dehydrogenase Inhibition on Stemness of Endometrial Cancer Stem Cells
Influence of Aldehyde Dehydrogenase Inhibition on Stemness of Endometrial Cancer Stem Cells Open
Endometrial cancer is one of the most common gynaecological malignancies. Although often diagnosed at an early stage, there is a subset of patients with recurrent and metastatic disease for whom current treatments are not effective. Cancer…
View article: The role of <scp>CD20</scp><sup>+</sup> T cells: Insights in human peripheral blood
The role of <span>CD20</span><sup>+</sup> T cells: Insights in human peripheral blood Open
CD20 + T cells constitute a small subset of T cells. These are found among CD4 + , CD8 + , CD4 + CD8 + , CD4 − CD8 − T, and TCRγδ + T cells, and have been poorly characterized. The aim of this study was to characterize peripheral blood (PB…
View article: CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression Open
Introduction In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation.…
View article: Optimization of Platelet-Rich Plasma Preparation for Regenerative Medicine: Comparison of Different Anticoagulants and Resuspension Media
Optimization of Platelet-Rich Plasma Preparation for Regenerative Medicine: Comparison of Different Anticoagulants and Resuspension Media Open
Platelet-rich plasma (PRP) has emerged as a promising therapy in regenerative medicine. However, the lack of standardization in PRP preparation protocols presents a challenge in achieving reproducible and accurate results. This study aimed…
View article: Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells
Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells Open
Low-grade inflammation is closely linked to obesity and obesity-related comorbidities; therefore, immune cells have become an important topic in obesity research. Here, we performed a deep phenotypic characterization of circulating T cells…
View article: Expression of IL-17RA in Innate Cells of Patients with Common Variable Immunodeficiency (CVID) and its Clinical Implications
Expression of IL-17RA in Innate Cells of Patients with Common Variable Immunodeficiency (CVID) and its Clinical Implications Open
Background. Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by B-cell dysfunction and immunoglobulin production deficiency. Dysregulation of interleukin-17 (IL-17) and its receptor IL-17RA have …
View article: Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling
Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling Open
Background Lung metastasis is the most adverse clinical factor and remains the leading cause of osteosarcoma-related death. Deciphering the mechanisms driving metastatic spread is crucial for finding open therapeutic windows for successful…
View article: CD8+ Treg cells play a role in the obesity-associated insulin resistance
CD8+ Treg cells play a role in the obesity-associated insulin resistance Open
Obesity-related chronic low-grade inflammation may trigger insulin resistance and type 2 diabetes (T2D) development. Cells with regulatory phenotype have been shown to be reduced during obesity, especially CD4+ Treg cells. However, little …