Aline Renata Pavan
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View article: Evaluation of new deferasirox-derived compounds for the treatment of iron overload
Evaluation of new deferasirox-derived compounds for the treatment of iron overload Open
Introduction: Iron overload is a major complication in individuals requiring frequent blood transfusions or those with genetic iron disorders. Because the body lacks a natural mechanism for iron excretion, iron chelation therapy is essenti…
View article: The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes
The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes Open
Class I histone deacetylases regulate gene transcription and are established therapeutic targets. HDAC1-3 form the catalytic subunit in several distinct multiprotein complexes; however, HDAC inhibitors are rarely studied in the context of …
View article: BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery
BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery Open
Tuberculosis (TB) has claimed more lives over the course of two millennia than any other infectious disease worldwide. In 2021, the World Health Organization (WHO) estimated that 10.6 million people were diagnosed with TB, resulting in the…
View article: Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3
Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3 Open
Cereblon-recruiting PROTACs can degrade HDAC1 with selectivity over HDAC3.
View article: Vascular Effects of the Fetal Hemoglobin Inducer Agent 3-(1,3-Dioxoisoindolin-2-yl) Benzyl Nitrate
Vascular Effects of the Fetal Hemoglobin Inducer Agent 3-(1,3-Dioxoisoindolin-2-yl) Benzyl Nitrate Open
Vascular endothelium is a protective layer of cells lining the lumen of blood vessels that plays important roles by releasing factors responsible for controlling the vascular tone, regulating the expression of pro-inflammatory cytokines, a…
View article: Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors
Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors Open
Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene expression through the deacetylation of histone lysine residues. Therefore, inhibition of HDACs has become an interesting approach for the treatment of seve…
View article: Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease
Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease Open
OPINION article Front. Med., 08 September 2022Sec. Hematology Volume 9 - 2022 | https://doi.org/10.3389/fmed.2022.1002063
View article: Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus
Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus Open
The role of epigenetic modifications on the carcinogenesis process has received a lot of attention in the last years. Among those, histone acetylation is a process regulated by histone deacetylases (HDAC) and histone acetyltransferases (HA…
View article: Benzofuroxan Derivatives as Potent Agents against Multidrug‐Resistant <i>Mycobacterium tuberculosis</i>
Benzofuroxan Derivatives as Potent Agents against Multidrug‐Resistant <i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB) is currently the leading cause of death related to infectious diseases worldwide, as reported by the World Health Organization. Moreover, the increasing number of multidrug‐resistant tuberculosis (MDR‐TB) cases has alarme…
View article: Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers
Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers Open
View article: Planejamento, síntese e avaliação farmacológica de novos derivados ftalimídicos inibidores de histona deacetilase para anemia falciforme
Planejamento, síntese e avaliação farmacológica de novos derivados ftalimídicos inibidores de histona deacetilase para anemia falciforme Open
View article: Synthesis, biological evaluation and bioavailability prediction of novel furoxan derivatives as leishmanicidal compounds
Synthesis, biological evaluation and bioavailability prediction of novel furoxan derivatives as leishmanicidal compounds Open
Leishmaniasis is a neglected tropical disease, endemic in 98 countries and with more than 350 million people with risk to be sick. From 2001 to 2014, leishmanisis caused 797,849 of new cases of cutaneous and mucosal forms. Moreover, only i…
View article: Epigenetic Regulatory Mechanisms Induced by Resveratrol
Epigenetic Regulatory Mechanisms Induced by Resveratrol Open
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic …
View article: Unraveling the Anticancer Effect of Curcumin and Resveratrol
Unraveling the Anticancer Effect of Curcumin and Resveratrol Open
Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer…
View article: Síntese, caracterização e avaliação biológica de quelatos metálicos contendo ligantes de origem natural
Síntese, caracterização e avaliação biológica de quelatos metálicos contendo ligantes de origem natural Open
O trabalho que será aqui apresentado teve como finalidade reunir os resultados obtidos dentro do Laboratório de Organometálicos II em relação aos estudos realizados acerca da interação de íons metálicos com ligantes orgânicos naturais. Os …
View article: Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events
Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events Open
Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet drugs. However, this therapy has several limitations, thereby justifying the developm…