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View article: Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated <scp>REM</scp> Sleep Behavior Disorder and Parkinson's Disease
Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated <span>REM</span> Sleep Behavior Disorder and Parkinson's Disease Open
Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used s…
View article: Non-motor symptoms in prodromal Parkinson's disease are linked to reduced quality of life
Non-motor symptoms in prodromal Parkinson's disease are linked to reduced quality of life Open
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) highlights an early α-synucleinopathy. This study compared health-related quality of life (hrQoL) in 62 individuals with iRBD with 19 healthy controls (HC) and 29 individuals…
View article: Elevated α-synuclein aggregate levels in the urine of patients with isolated REM sleep behavior disorder and Parkinson’s disease
Elevated α-synuclein aggregate levels in the urine of patients with isolated REM sleep behavior disorder and Parkinson’s disease Open
Parkinson’s disease is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for Parkinson’s disease and related synucleinopathies. This …
View article: Context-dependency of the REM sleep behavior disorder screening questionnaire - Clinical utility under scrutiny
Context-dependency of the REM sleep behavior disorder screening questionnaire - Clinical utility under scrutiny Open
Our findings underscore the context-dependency of the RBDSQ and fluctuations in self-awareness of sleep-related behaviors, necessitating a critical appraisal of questionnaire-based RBD screening tools. Future studies should explore strateg…
View article: Cognitive training and promoting a healthy lifestyle for individuals with isolated REM sleep behavior disorder: study protocol of the delayed-start randomized controlled trial CogTrAiL-RBD
Cognitive training and promoting a healthy lifestyle for individuals with isolated REM sleep behavior disorder: study protocol of the delayed-start randomized controlled trial CogTrAiL-RBD Open
Background Isolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive dysfunctions predict earlier phenotypic conversion from iRBD to Parkinson’s disease and …
View article: Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease
Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease Open
IMPORTANCE Nonmotor symptoms of Parkinson disease (PD) often predate the movement disorder by decades. Currently, there is no blood biomarker to define this prodromal phase. OBJECTIVE To investigate whether α-synuclein in neuronally derive…
View article: Non-Motor symptoms in prodromal Parkinson’s disease are linked to reduced Quality of Life
Non-Motor symptoms in prodromal Parkinson’s disease are linked to reduced Quality of Life Open
Background Isolated REM sleep behavior disorder (iRBD) is the most specific prodromal marker of Parkinson’s disease (PD), often accompanied by various non-motor symptoms. In PD, non-motor symptoms are strongly associated with reduced healt…
View article: Quantification of the neurochemical profile of the human putamen using STEAM MRS in a cohort of elderly subjects at 3 T and 7 T: Ruminations on the correction strategy for the tissue voxel composition
Quantification of the neurochemical profile of the human putamen using STEAM MRS in a cohort of elderly subjects at 3 T and 7 T: Ruminations on the correction strategy for the tissue voxel composition Open
The aim of this work is to quantify the metabolic profile of the human putamen in vivo in a cohort of elderly subjects using single-voxel proton magnetic resonance spectroscopy. To obtain metabolite concentrations specific to the putamen, …
View article: Evaluation of a Structured Screening Assessment to Detect Isolated Rapid Eye Movement Sleep Behavior Disorder
Evaluation of a Structured Screening Assessment to Detect Isolated Rapid Eye Movement Sleep Behavior Disorder Open
Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) cohorts have provided insights into the earliest neurodegenerative processes in α‐synucleinopathies. Even though polysomnography (PSG) remains the gold standard fo…
View article: Visuo‐spatial processing is linked to cortical glutamate dynamics in Parkinson's disease — a 7‐T functional <scp>magnetic resonance spectroscopy</scp> study
Visuo‐spatial processing is linked to cortical glutamate dynamics in Parkinson's disease — a 7‐T functional <span>magnetic resonance spectroscopy</span> study Open
Background and purpose Cognitive decline is a frequent and debilitating non‐motor symptom for patients with Parkinson's disease (PD). Metabolic alterations in the occipital cortex during visual processing may serve as a biomarker for cogni…
View article: Altered glutamate signaling in Parkinson’s disease patients with REM sleep behavior disorder
Altered glutamate signaling in Parkinson’s disease patients with REM sleep behavior disorder Open
Background and Objectives Clinical heterogeneity of patients with Parkinson’s disease is well recognized. Parkinson’s disease with rapid eye movement (REM) sleep behavior disorder (RBD) is a more malignant phenotype with faster motor progr…
View article: Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy Open
Background Skin biopsy is a potential tool for the premortem confirmation of an α‐synucleinopathy. Objective The aim was to assess the aggregation assay real‐time quaking‐induced conversion (RT‐QuIC) of skin biopsy lysates to confirm isola…
View article: Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool Open
Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates i…
View article: Compensatory mechanisms enables intelligibility in prodromal Parkinson’s disease
Compensatory mechanisms enables intelligibility in prodromal Parkinson’s disease Open
Background Speech impairment is already present on the acoustic level in speakers with isolated rapid eye movement sleep behavior disorder (iRBD). The aim of this study was to determine whether speech changes are already present on the art…
View article: Evaluation of a structured screening assessment to detect patients with isolated REM Sleep Behavior Disorder
Evaluation of a structured screening assessment to detect patients with isolated REM Sleep Behavior Disorder Open
Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) cohorts have provided novel insights in the earliest neurodegenerative processes in α-synucleinopathies. Even though polysomnography remains the gold standard for …
View article: Combining skin and olfactory α-synuclein RT-QuIC - towards biomarker-driven phenotyping in synucleinopathies
Combining skin and olfactory α-synuclein RT-QuIC - towards biomarker-driven phenotyping in synucleinopathies Open
Seeding assays, such as real-time quaking-induced conversion (RT-QuIC), are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) h…
View article: Fronto-Striatal Dynamic Connectivity is linked to Dopaminergic Motor Response in Parkinson’s Disease
Fronto-Striatal Dynamic Connectivity is linked to Dopaminergic Motor Response in Parkinson’s Disease Open
Background Differences in dopaminergic motor response in Parkinson’s disease (PD) patients are related to specific PD subtypes. An important factor driving dopaminergic response might lie in the temporal dynamics in corticostriatal connect…
View article: Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease Open
Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and t…
View article: Putaminal <scp>y</scp>‐Aminobutyric Acid Modulates Motor Response to Dopaminergic Therapy in Parkinson's Disease
Putaminal <span>y</span>‐Aminobutyric Acid Modulates Motor Response to Dopaminergic Therapy in Parkinson's Disease Open
Background Motor response to dopaminergic therapy is a characteristic of patients with Parkinson's disease (PD). Whether nondopaminergic neurotransmitters contribute to treatment response is uncertain. Objectives The aim of this study is t…
View article: Microsleep disturbances are associated with noradrenergic dysfunction in Parkinson’s disease
Microsleep disturbances are associated with noradrenergic dysfunction in Parkinson’s disease Open
Study Objectives Parkinson’s disease (PD) commonly involves degeneration of sleep-wake regulating brainstem nuclei; likewise, sleep-wake disturbances are highly prevalent in PD patients. As polysomnography macroparameters typically show on…