Alireza Zali
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View article: Timing, safety, and efficacy of initiating anticoagulation in intracranial surgery: a systematic review and meta-analysis
Timing, safety, and efficacy of initiating anticoagulation in intracranial surgery: a systematic review and meta-analysis Open
Introduction Venous thromboembolism (VTE) is a major cause of early mortality after tumor craniotomy, yet the optimal timing of pharmacologic prophylaxis remains uncertain. Methods We conducted a PRISMA-guided systematic review and meta-an…
View article: Evaluation of Cardiac Complications due to Mannitol Application in Elevated Intracranial Pressure patients: A Systematic Review and Meta-analysis
Evaluation of Cardiac Complications due to Mannitol Application in Elevated Intracranial Pressure patients: A Systematic Review and Meta-analysis Open
Background Mannitol is a widely used hyperosmotic agent for intracranial pressure (ICP) control, yet its cardiovascular safety profile remains uncertain. This systematic review and meta-analysis aimed to evaluate cardiac complications and …
View article: Cost-effectiveness of craniotomy approaches for different intracranial pathologies in comparison to each other, a systematic review
Cost-effectiveness of craniotomy approaches for different intracranial pathologies in comparison to each other, a systematic review Open
Background Craniotomy is one of the most resource-intensive neurosurgical procedures, yet comparative information on its cost-effectiveness across different pathologies is limited. Differences in surgical techniques such as decompressive v…
View article: Subthalamic Nucleus(STN) versus Globus Pallidus Internus(GPi) targeted with Deep Brain Stimulation in Parkinson’s Disease: A Systematic Review and Meta-Analysis of tremor outcome
Subthalamic Nucleus(STN) versus Globus Pallidus Internus(GPi) targeted with Deep Brain Stimulation in Parkinson’s Disease: A Systematic Review and Meta-Analysis of tremor outcome Open
Background Deep Brain Stimulation (DBS) is an established and effective treatment for patients with Parkinson’s disease (PD). Over recent decades, several brain targets have been explored for DBS, including the subthalamic nucleus (STN) an…
View article: Combined Subtotal Resection and Stereotactic Radiosurgery for Large Vestibular Schwannomas: A Systematic Review and Meta-Analysis
Combined Subtotal Resection and Stereotactic Radiosurgery for Large Vestibular Schwannomas: A Systematic Review and Meta-Analysis Open
Background Large vestibular schwannomas (VSs), particularly Koos grade III–IV, often require a balance between tumor control and cranial nerve preservation. This meta-analysis evaluates outcomes of planned subtotal or near-total resection …
View article: Modulation of Gut Microbiota and Gut-Brain Axis as a Therapeutic approach in Traumatic brain injury: Implications for Neurological Outcomes
Modulation of Gut Microbiota and Gut-Brain Axis as a Therapeutic approach in Traumatic brain injury: Implications for Neurological Outcomes Open
Objective This systematic review aimed to evaluate the impact of gut microbiota modulation including probiotics, dietary interventions, and enteral nutrition strategies on neurological recovery, functional outcomes, morbidity, and mortalit…
View article: Artificial Intelligence Models for Predicting Molecular Pathway Activity in Spinal Cord Injury: A Systematic Review
Artificial Intelligence Models for Predicting Molecular Pathway Activity in Spinal Cord Injury: A Systematic Review Open
Background: Spinal cord injury (SCI) remains a devastating neurological condition with high global incidence and minimal curative options. The pathobiology is multifactorial, encompassing acute mechanical insult, sustained neuroinflammatio…
View article: Neuroprotective Effects of Vitamin D Supplementation on Outcomes in Traumatic Brain Injury: A Systematic Review and Meta-Analysis
Neuroprotective Effects of Vitamin D Supplementation on Outcomes in Traumatic Brain Injury: A Systematic Review and Meta-Analysis Open
Background Traumatic brain injury (TBI) remains a leading cause of morbidity and mortality worldwide, with secondary brain damage driven by inflammation and oxidative stress. Vitamin D is increasingly recognized for potential neuroprotecti…
View article: Neoadjuvant Bevacizumab in Newly Diagnosed, Surgically Resectable Glioblastoma: A Systematic Review and Meta-Analysis of Survival and Functional Outcomes
Neoadjuvant Bevacizumab in Newly Diagnosed, Surgically Resectable Glioblastoma: A Systematic Review and Meta-Analysis of Survival and Functional Outcomes Open
Background Glioblastoma (GBM) remains one of the most aggressive primary brain tumors, with limited survival despite maximal safe resection and chemoradiotherapy. Neoadjuvant bevacizumab (BEV) has been proposed to reduce peritumoral edema,…
View article: Double-edged sword effect of Sutterella in neurological disorders: implications for the gut-brain axis and neuroimmune interactions
Double-edged sword effect of Sutterella in neurological disorders: implications for the gut-brain axis and neuroimmune interactions Open
The genus Sutterella, a group of bile-resistant microaerophilic gram-negative bacteria, has emerged as a key player in gut-brain axis communication, with significant yet complex implications for neurological and psychiatric disorders. This…
View article: Annual SZ® A Novel Formulation For COVID-19 Therapy Clinical Trial Studies
Annual SZ® A Novel Formulation For COVID-19 Therapy Clinical Trial Studies Open
View article: Surgical Nerve Decompression at Lower Extremity for Diabetic Neuropathy: A Systematic Review and Meta-Analysis of Time-Dependent Pain, Sensory Recovery, Amputation, Ulcer Recurrence, and Balance
Surgical Nerve Decompression at Lower Extremity for Diabetic Neuropathy: A Systematic Review and Meta-Analysis of Time-Dependent Pain, Sensory Recovery, Amputation, Ulcer Recurrence, and Balance Open
Surgical nerve decompression demonstrates sustained efficacy in pain management and substantially reduces severe diabetic neuropathy complications. Future high-quality randomized controlled trials are necessary to standardize outcomes and …
View article: Neurological, functional, and quality of life outcomes following combined mesenchymal stem cell and Schwann cell therapy in spinal cord injury: a 9-year experience
Neurological, functional, and quality of life outcomes following combined mesenchymal stem cell and Schwann cell therapy in spinal cord injury: a 9-year experience Open
This study demonstrates significant neurological, functional, and quality of life improvements following combined cell therapy with autologous MSCs and SCs in patients with complete SCI. Future research should investigate potential synergi…
View article: Repeated intrathecal injections of autologous bone marrow-derived mesenchymal stem cells for spastic cerebral palsy: Single-arm safety and preliminary efficacy clinical trial
Repeated intrathecal injections of autologous bone marrow-derived mesenchymal stem cells for spastic cerebral palsy: Single-arm safety and preliminary efficacy clinical trial Open
View article: Advances in magnetic field approaches for non-invasive targeting neuromodulation
Advances in magnetic field approaches for non-invasive targeting neuromodulation Open
Neuromodulation, the targeted regulation of nerve activity, has emerged as a promising approach for treating various neurological and psychiatric disorders. While deep brain stimulation has shown efficacy, its invasive nature poses substan…
View article: Evaluation of Complications Associated with Hypertonic Saline versus Mannitol in the Management of Intracranial Hypertension and Their Mitigation Strategies: A Systematic Review
Evaluation of Complications Associated with Hypertonic Saline versus Mannitol in the Management of Intracranial Hypertension and Their Mitigation Strategies: A Systematic Review Open
Title Evaluation of Complications Associated with Hypertonic Saline versus Mannitol in the Management of Intracranial Hypertension and Their Mitigation Strategies: A Systematic Review Background Intracranial hypertension (ICH) worsens outc…
View article: Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled Trial
Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled Trial Open
Neuropathic pain is a debilitating complication following spinal cord injury (SCI). Currently, effective treatments for SCI-induced neuropathic pain are highly lacking. This clinical trial aimed to investigate the efficacy of combined intr…
View article: Artificial intelligence in Glioblastoma Diagnostics: Integrating MRI, histopathology, and molecular profiling
Artificial intelligence in Glioblastoma Diagnostics: Integrating MRI, histopathology, and molecular profiling Open
AI is a promising decision-support adjunct to MRI, histopathology, and molecular profiling, with potential to improve diagnostic accuracy and efficiency. Routine adoption requires prospective multi-center validation with external cohorts, …
View article: Deep Brain Stimulation for Refractory Epilepsy: A Meta-Analysis of Stimulation Parameters
Deep Brain Stimulation for Refractory Epilepsy: A Meta-Analysis of Stimulation Parameters Open
Epilepsy affects 50 million people worldwide, with 30% not responding to antiepileptic drugs. Surgical resective intervention may help some patients, and neuromodulation therapies like deep brain stimulation are becoming important treatmen…
View article: Artificial intelligence role in advancement of human brain connectome studies
Artificial intelligence role in advancement of human brain connectome studies Open
Neurons are interactive cells that connect via ions to develop electromagnetic fields in the brain. This structure functions directly in the brain. Connectome is the data obtained from neuronal connections. Since neural circuits change in …
View article: Metformin and its potential influence on cell fate decision between apoptosis and senescence in cancer, with a special emphasis on glioblastoma
Metformin and its potential influence on cell fate decision between apoptosis and senescence in cancer, with a special emphasis on glioblastoma Open
Despite reaching enormous achievements in therapeutic approaches worldwide, GBM still remains the most incurable malignancy among various cancers. It emphasizes the necessity of adjuvant therapies from the perspectives of both patients and…
View article: Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial
Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial Open
Iranian Registry of Clinical Trials, IRCT20200502047277N1. Registered 2 October 2020, https://en.irct.ir/trial/48765 .
View article: Molecular dynamic simulation reveals the inhibiting impact of Rhein on wild-type and P29S-mutated Rac1
Molecular dynamic simulation reveals the inhibiting impact of Rhein on wild-type and P29S-mutated Rac1 Open
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase belonging to the Rho family. It acts as a binary molecular switch regulating several cellular functions, including cell adhesion and migration. Malfunctions due to the P29…
View article: Surgical Management of Tuberculosis-related Cerebral Disorders: A Retrospective Single-center Study
Surgical Management of Tuberculosis-related Cerebral Disorders: A Retrospective Single-center Study Open
Background: Tuberculosis (TB) remains a significant global health concern, with extrapulmonary manifestations, including central nervous system involvement, posing substantial morbidity and mortality. While medical treatment with anti-TB d…
View article: Accuracy of Noninvasive Intracranial Pressure Monitoring in Patients with Subarachnoid Hemorrhage
Accuracy of Noninvasive Intracranial Pressure Monitoring in Patients with Subarachnoid Hemorrhage Open
Background: Subarachnoid hemorrhage (SAH) can lead to elevated intracranial pressure (ICP), which poses significant risks of morbidity and mortality. Monitoring ICP is crucial for the early detection and management of these complications i…
View article: Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study
Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study Open
Introduction: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran. Meth…
View article: Efficacy and Safety of Vaccines After Conventional Treatments for Survival of Gliomas: A Systematic Review and Meta-Analysis
Efficacy and Safety of Vaccines After Conventional Treatments for Survival of Gliomas: A Systematic Review and Meta-Analysis Open
Background: Malignant gliomas are known with poor prognosis and low rate of survival among brain tumors. Resection surgery is followed by chemotherapy and radiotherapy in treatment of gliomas which is known as the conventional treatment. H…
View article: Covid-19 in Parkinson's Disease treated by drugs or brain stimulation
Covid-19 in Parkinson's Disease treated by drugs or brain stimulation Open
PD patients possibly follow tighter preventive protocols, which lead to lower prevalence and severity of Covid-19 and its consequences in these patients. Although it seems Covid-19 does not affect motor and psychological aspects of PD as m…
View article: Efficacy of vagus nerve stimulation for children with drug-resistant epilepsy: Retrospective study
Efficacy of vagus nerve stimulation for children with drug-resistant epilepsy: Retrospective study Open
Introduction: According to current investigations, there are controversy in our knowledge regarding the safety and efficacy of Vagus Nerve Stimulation (VNS) in children younger than 12 years old. Therefore, we performed this study and aime…
View article: Combined Mesenchymal Stem Cell and Schwann Cell Therapy in Spinal Cord Injury: A 9-Year Cohort Study
Combined Mesenchymal Stem Cell and Schwann Cell Therapy in Spinal Cord Injury: A 9-Year Cohort Study Open