Alisa Kachikis
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View article: Infant CD4 T-Cell Response to SARS-CoV-2 mRNA Vaccination Is Restricted in Cytokine Production and Modified by Vaccine Manufacturer
Infant CD4 T-Cell Response to SARS-CoV-2 mRNA Vaccination Is Restricted in Cytokine Production and Modified by Vaccine Manufacturer Open
Background Safe and effective vaccines are a key preventative measure to protect infants from SARS-CoV-2 infection and disease. Although mRNA vaccines induce robust antibody titers in infants, little is known about the quality of CD4 T-cel…
View article: Transplacental transfer of maternal SARS-CoV-2 antibodies in dichorionic and monochorionic twin pregnancies
Transplacental transfer of maternal SARS-CoV-2 antibodies in dichorionic and monochorionic twin pregnancies Open
Background Maternal immunization relies on active transplacental transfer of immunoglobulin G. However, very little is known about the efficacy of maternal immunization in the setting of multiple gestation. We aimed to investigate transpla…
View article: Understanding GBS infection in pregnancy: exploring adverse maternal and pregnancy outcomes and the prospect of a GBS vaccine
Understanding GBS infection in pregnancy: exploring adverse maternal and pregnancy outcomes and the prospect of a GBS vaccine Open
Group B streptococcus (GBS) or Streptococcus agalactiae is a beta-hemolytic, Gram-positive coccus that can colonize the genitourinary and gastrointestinal tract of pregnant people. GBS can transition from asymptomatic colonization to patho…
View article: The burden, pathogenesis, clinical outcomes, and treatment of common respiratory virus infections during pregnancy
The burden, pathogenesis, clinical outcomes, and treatment of common respiratory virus infections during pregnancy Open
Respiratory illnesses due to respiratory virus infections disproportionately impact pregnant individuals and their infants, leading to significant morbidity and mortality globally. Data describing the incidence and impact of these infectio…
View article: Infant CD4 T-cell response to SARS-CoV-2 mRNA vaccination is restricted in cytokine production and modified by vaccine manufacturer
Infant CD4 T-cell response to SARS-CoV-2 mRNA vaccination is restricted in cytokine production and modified by vaccine manufacturer Open
BACKGROUND Safe and effective vaccines are a key preventative measure to protect infants from SARS-CoV-2 infection and disease. Although mRNA vaccines induce robust antibody titers in infants, little is known about the quality of CD4 T-cel…
View article: Preterm Birth Frequency and Associated Outcomes From the MATISSE (Maternal Immunization Study for Safety and Efficacy) Maternal Trial of the Bivalent Respiratory Syncytial Virus Prefusion F Protein Vaccine
Preterm Birth Frequency and Associated Outcomes From the MATISSE (Maternal Immunization Study for Safety and Efficacy) Maternal Trial of the Bivalent Respiratory Syncytial Virus Prefusion F Protein Vaccine Open
OBJECTIVE: To describe preterm birth frequency and newborn and infant outcomes overall and among preterm children in the MATISSE (Maternal Immunization Study for Safety and Efficacy) trial of maternal vaccination with bivalent respiratory …
View article: Maternal-Infant Respiratory Syncytial Virus and Influenza A Virus Antibody Transfer in Preterm and Full-term Infants
Maternal-Infant Respiratory Syncytial Virus and Influenza A Virus Antibody Transfer in Preterm and Full-term Infants Open
Background Immunization against influenza and respiratory syncytial virus (RSV) protects pregnant individuals and their infants against infection via transplacental transport of immunoglobulin G (IgG). We sought to evaluate the quantity an…
View article: Evaluation of Transplacental Maternal SARS-CoV-2 Antibody Transfer in Small for Gestational Age Infants
Evaluation of Transplacental Maternal SARS-CoV-2 Antibody Transfer in Small for Gestational Age Infants Open
Little is known about the potential benefits of maternal immunization in the setting of high-risk pregnancies resulting in small-for-gestational-age (SGA) infants. This study compares transplacental transfer of maternal SARS-CoV-2 anti-Spi…
View article: Elevated Cardiovascular Biomarkers Following Hypertensive Disorder of Pregnancy
Elevated Cardiovascular Biomarkers Following Hypertensive Disorder of Pregnancy Open
Hypertensive disorder of pregnancy (HDP) is associated with an increased risk for later-life cardiovascular disease (CVD). Whether the HDP pregnancy itself confers risk towards CVD later in life is suggested in several epidemiologic studie…
View article: Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants
Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants Open
Background Respiratory syncytial virus (RSV)–associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (<2500 g). Studies have demonstrated decreased materna…
View article: Pregnancy and Cancer—Navigating Impossible Decisions
Pregnancy and Cancer—Navigating Impossible Decisions Open
Paul Gougis, MD; Anne-Sophie Hamy, MD, PhD; Floriane Jochum, MD; Kevin Bihan, PharmD; Marie Carbonnel, MD; Joe-Elie Salem, MD, PhD; Elise Dumas, PhD; Rayan Kabirian, MD; Beatriz Grandal, MD, PhD; Solenn Barraud, MD; Florence Coussy, MD, Ph…
View article: Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study
Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study Open
When Omicron was the variant of concern, newborns of unvaccinated mothers had an increased risk for neonatal death. Neonates of vaccinated mothers had a decreased risk for preterm birth and adverse neonatal outcomes. Because the protective…
View article: Hybrid Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection or Vaccination Alone
Hybrid Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection or Vaccination Alone Open
In pregnant people with prior SARS-CoV-2 infection, hybrid immunity (infection plus vaccination) before delivery provided more durable maternally-derived antibody responses than infection or vaccination alone in infants through 6 months of…
View article: Timing of Maternal COVID-19 Vaccine and Antibody Concentrations in Infants Born Preterm
Timing of Maternal COVID-19 Vaccine and Antibody Concentrations in Infants Born Preterm Open
Importance COVID-19 vaccine–derived antibodies in pregnant people may protect infants from severe infection in the first 6 months of life via transplacental antibody transfer. Few data exist on maternally derived SARS-CoV-2 antibodies in p…
View article: Hybrid Immunity to SARS-CoV-2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection Alone
Hybrid Immunity to SARS-CoV-2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection Alone Open
Background Hybrid immunity (infection plus vaccination) may increase maternally derived SARS-CoV-2 antibody responses and durability versus infection alone. Methods Prospective cohort of pregnant participants with prior SARS-CoV-2 infectio…
View article: 478. COVID-19 maternal antibody concentrations in twin infants: impact of multiple pregnancy on transplacental antibody transfer during pregnancy
478. COVID-19 maternal antibody concentrations in twin infants: impact of multiple pregnancy on transplacental antibody transfer during pregnancy Open
Background COVID-19 vaccines in pregnancy protect both pregnant individuals and young infants from severe illness via transplacental transfer of maternally-derived IgG. However, the impact of multiple (e.g. twin) pregnancy on transplacenta…
View article: 479. Optimizing maternal COVID-19 vaccine antibodies in low birthweight infants: is timing everything?
479. Optimizing maternal COVID-19 vaccine antibodies in low birthweight infants: is timing everything? Open
Background COVID-19 vaccines in pregnancy may protect young infants from severe illness via maternally-derived IgG. Transplacental transfer of maternal IgG is thought to be decreased in infants with low-birth weight (LBW). The impact of ma…
View article: 2079. Maternal hybrid immunity to SARS-CoV-2 during pregnancy provides more durable infant antibody responses compared to natural infection alone
2079. Maternal hybrid immunity to SARS-CoV-2 during pregnancy provides more durable infant antibody responses compared to natural infection alone Open
Background Immunity from natural infection and vaccination (hybrid) may provide more durable SARS-CoV-2 antibody responses; whether this increases durability of maternally-derived antibody responses in infants is unknown. Methods Participa…
View article: Risk Factors Associated with Congenital Syphilis, Georgia, 2008-2015
Risk Factors Associated with Congenital Syphilis, Georgia, 2008-2015 Open
Background. Congenital syphilis (CS) is associated with significant perinatal morbidity and mortality. The study objectives were to compare risk factors among women with syphilis infection whose pregnancies did and did not result in CS cas…
View article: Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination Open
View article: Severe acute respiratory syndrome coronavirus 2 seroprevalence and longitudinal antibody response following natural infection in pregnancy: A prospective cohort study
Severe acute respiratory syndrome coronavirus 2 seroprevalence and longitudinal antibody response following natural infection in pregnancy: A prospective cohort study Open
Background: Antenatal care provides unique opportunities to assess severe acute respiratory syndrome coronavirus 2 seroprevalence and antibody response duration after natural infection detected during pregnancy; transplacental antibody tra…
View article: SARS-CoV-2 seroprevalence and longitudinal antibody response following natural infection in pregnancy: a prospective cohort study
SARS-CoV-2 seroprevalence and longitudinal antibody response following natural infection in pregnancy: a prospective cohort study Open
Importance Antenatal care provides unique opportunities to assess SARS-CoV-2 seroprevalence and antibody response duration after natural infection detected during pregnancy; transplacental antibody transfer may inform peripartum and neonat…
View article: Evaluation and clinical validation of monkeypox (mpox) virus real-time PCR assays
Evaluation and clinical validation of monkeypox (mpox) virus real-time PCR assays Open
View article: 1958. Longitudinal SARS-COV-2 anti-spike antibody response in pregnant people with natural infection and variable vaccine uptake
1958. Longitudinal SARS-COV-2 anti-spike antibody response in pregnant people with natural infection and variable vaccine uptake Open
Background Natural SARS-CoV-2 infection results in anti-nucleocapsid (N) and anti-spike (S) antibody (Ab) development. Anti-S Ab response (conferred by infection and/or vaccination) is more closely associated with protection. We evaluated …
View article: Evaluation and Clinical Validation of Monkeypox Virus Real-Time PCR Assays
Evaluation and Clinical Validation of Monkeypox Virus Real-Time PCR Assays Open
BACKGROUND In spring of 2022, an outbreak of monkeypox spread worldwide. Here, we describe performance characteristics of monkeypox virus (MPXV)-specific and pan-orthopoxvirus qPCR assays for clinical use. METHODS We validated probe-based …
View article: Analysis of Vaccine Reactions After COVID-19 Vaccine Booster Doses Among Pregnant and Lactating Individuals
Analysis of Vaccine Reactions After COVID-19 Vaccine Booster Doses Among Pregnant and Lactating Individuals Open
This study suggests that COVID-19 vaccine boosters or third doses were well tolerated among pregnant and lactating individuals. Data to evaluate tolerability of boosters or additional doses among pregnant and lactating individuals will be …
View article: Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination Open
Human breastmilk is rich in T cells; however, their specificity and function are largely unknown. We compared the phenotype, diversity, and antigen specificity of T cells in the breastmilk and peripheral blood of lactating individuals who …
View article: Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing for Obstetric Inpatient Units Across the United States
Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing for Obstetric Inpatient Units Across the United States Open
Background The purpose of this study was to estimate prevalence of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among patients admitted to obstetric inpatient units throughout the United States as det…
View article: 489. SARS-CoV-2 Seroprevalence and Antibody Response Among Pregnant People in Seattle, WA
489. SARS-CoV-2 Seroprevalence and Antibody Response Among Pregnant People in Seattle, WA Open
Background Antenatal care is a unique opportunity to assess SARS-CoV-2 seroprevalence and antibody response in pregnant people, including those with previously unknown infection. Methods Pregnant people were screened for SARS-CoV-2 IgG dur…
View article: Complete Molar Pregnancies with a Coexisting Fetus: Pregnancy Outcomes and Review of Literature
Complete Molar Pregnancies with a Coexisting Fetus: Pregnancy Outcomes and Review of Literature Open
Objective The objective of the study was to review the obstetric outcomes of complete hydatidiform molar pregnancies with a coexisting fetus (CHMCF), a rare clinical entity that is not well described. Materials and Methods We performed a r…