Alisa Phulukdaree
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View article: Unveiling the Link: The Potential Roles of Vitamin D in Keloid Pathophysiology
Unveiling the Link: The Potential Roles of Vitamin D in Keloid Pathophysiology Open
Keloid disease, a fibroproliferative skin disorder, is characterised by scar tissue growth that extends beyond the original wound boundaries. Despite advancements, current treatments, particularly surgical excision, often result in high re…
View article: A novel methodology for modelling images using level-sets with application to atopic asthma fibrin networks
A novel methodology for modelling images using level-sets with application to atopic asthma fibrin networks Open
View article: Scanning Electron and Atomic Force Microscopic Analysis of Erythrocytes in a Cohort of Atopic Asthma Patients—A Pilot Study
Scanning Electron and Atomic Force Microscopic Analysis of Erythrocytes in a Cohort of Atopic Asthma Patients—A Pilot Study Open
Background: Non-communicable diseases are often associated with chronic inflammation, placing patients suffering from these conditions at a higher risk of thrombosis and other complications. The pathophysiology of asthma and/or atopic asth…
View article: Patulin suppresses α1-adrenergic receptor expression in HEK293 cells
Patulin suppresses α1-adrenergic receptor expression in HEK293 cells Open
View article: Mycotoxin-induced cytotoxicity of commercially available pelleted feline feed in feline peripheral blood mononuclear cells <i>Ex Vivo</i>
Mycotoxin-induced cytotoxicity of commercially available pelleted feline feed in feline peripheral blood mononuclear cells <i>Ex Vivo</i> Open
Mycotoxin contamination is a major concern in developing countries such as South Africa, with pelleted pet foods often being contaminated with mycotoxins that have a negative impact on pet health. This study investigated the cytotoxicity o…
View article: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)
Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s) Open
In PBMC's and THP-1 cells, WRE proved to effectively modulate antioxidant activity, inflammatory cytokines and cell death. In THP-1 cells, WRE decreased pro-inflammatory cytokine levels, which may alleviate cancer cac…
View article: Additional file 1: of Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMCâ s)
Additional file 1: of Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMCâ s) Open
Assay data from root extract of W. Somnifera. (XLSX 288 kb)
View article: Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)
Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s) Open
In PBMC's and THP-1 cells, CLE proved to effectively modulate antioxidant activity, inflammatory cytokines and cell death. In THP-1 cells, CLE decreased pro-inflammatory cytokine levels whereas it increased anti-infla…
View article: Pro-Inflammatory Cytokine Levels in HIV Infected and Uninfected Pregnant Women with and without Preeclampsia
Pro-Inflammatory Cytokine Levels in HIV Infected and Uninfected Pregnant Women with and without Preeclampsia Open
INTRODUCTION
\nPreeclampsia and HIV/AIDS are inflammatory conditions that contribute significantly to
\nadverse maternal and foetal outcomes. The immune reconstitution effects of HAART on
\ninflammatory mediators has not been adequately st…
View article: Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease Open
Both SNP variant alleles occurred more frequently in SA Indians than in SA blacks. A larger study group and further analysis is required to assess whether these SIRT1 SNPs may serve as risk factors that contribute to Indians developing ear…
View article: Comparison of Antioxidant Effects of Kolaviron and Vitamin C Interventions on Testicular Structures Following Nevirapine Administration in Sprague-Dawley Rats
Comparison of Antioxidant Effects of Kolaviron and Vitamin C Interventions on Testicular Structures Following Nevirapine Administration in Sprague-Dawley Rats Open
Testicular toxicity has been implicated in highly active anti-retroviral therapy (HAART) treatment.Hence there is need to identify an effective antioxidant product that can alleviate testicular necrosis due to HAART administration.Forty ei…
View article: Pro-inflammatory cytokine levels in HIV infected and uninfected pregnant women with and without pre-eclampsia
Pro-inflammatory cytokine levels in HIV infected and uninfected pregnant women with and without pre-eclampsia Open
DRRM cytokine analysis
View article: Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line
Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line Open
Increased death rates due to lung cancer have necessitated the search for potential novel anticancer compounds such as carbazole derivatives. Carbazoles are aromatic heterocyclic compounds with anticancer, antibacterial and anti-inflammato…
View article: Mitochondrial and Oxidative Stress Response in HepG2 Cells Following Acute and Prolonged Exposure to Antiretroviral Drugs
Mitochondrial and Oxidative Stress Response in HepG2 Cells Following Acute and Prolonged Exposure to Antiretroviral Drugs Open
Chronic HIV treatment with antiretroviral drugs has been associated with adverse health outcomes. Mitochondrial toxicity exhibited by nucleoside reverse transcriptase inhibitors (NRTIs) is pinpointed as a molecular mechanism of toxicity. T…