Alison Alexandra Wright
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Optimizing Olfactory Ensheathing Cell Transplantation for Spinal Cord Injury Repair Open
Cell transplantation constitutes an important avenue for development of new treatments for spinal cord injury (SCI). These therapies are aimed at supporting neural repair and/or replacing lost cells at the injury site. To date, various cel…
Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells Open
Macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity with key roles in neural regeneration and responses to pathogens, amongst a multitude of other functions. The expression of MIF and its binding partn…
Olfactory Ensheathing Cell Behaviour and Interactions are Modulated by Secreted Products of OECs Open
The work presented in this thesis demonstrates that (1) the neurotrophins NGF and BDNF, which are secreted from OECs, significantly increase OEC proliferation, migration and phagocytosis; (2) OECs in vivo and in culture express the cytokin…
Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins Open
Autologous olfactory ensheathing cell (OEC) transplantation is a promising therapy for spinal cord injury; however, the efficacy varies between trials in both animals and humans. The main reason for this variability is that the purity and …
The Glia Response after Peripheral Nerve Injury: A Comparison between Schwann Cells and Olfactory Ensheathing Cells and Their Uses for Neural Regenerative Therapies Open
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems. PNS glia respond rapi…