Alison E. Ringel
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View article: FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis Open
Little is known about the role of autophagy in the human humoral immune system. Here, we found that in B cells, genetic ablation of FIP200, a mammalian metabolic sensor that regulates autophagy in response to a range of stimuli, led to dim…
View article: PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion Open
Although PD-1 inhibitors are FDA-approved for over 25 different cancers, the mechanisms contributing to response remain incompletely understood. To investigate how PD-1–deleted CD8+ T cells influence PD-1–expressing CD8+ T cells in the sam…
View article: Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions
Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions Open
Tumors are inherently embedded in systemic physiology, which contributes metabolites, signaling molecules, and immune cells to the tumor microenvironment. As a result, any systemic change to host metabolism can impact tumor progression and…
View article: Figure S2 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S2 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 2
View article: Figure S7 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S7 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 7
View article: Figure S4 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S4 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 4
View article: Data from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Data from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Progressive decline of the adaptive immune system with increasing age coincides with a sharp increase in cancer incidence. In this study, we set out to understand whether deficits in antitumor immunity with advanced age promote tumor progr…
View article: Figure S5 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S5 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 5
View article: Figure S1 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S1 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 1
View article: Figure S6 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S6 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 6
View article: Figure S8 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S8 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 8
View article: Figure S3 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Figure S3 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Supplemental Figure 3
View article: PPARγ downregulation in colonic CD8+ T cells results in epithelial barrier disruption in people with HIV on antiretroviral therapy
PPARγ downregulation in colonic CD8+ T cells results in epithelial barrier disruption in people with HIV on antiretroviral therapy Open
SUMMARY A hallmark of HIV infection is disruption of intestinal barrier integrity that persists in people with HIV (PWH) despite treatment with antiretroviral therapy (ART). This disruption is central to HIV disease progression, yet the ca…
View article: Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity Open
Progressive decline of the adaptive immune system with increasing age coincides with a sharp increase in cancer incidence. In this study, we set out to understand whether deficits in antitumor immunity with advanced age promote tumor progr…
View article: Supplementary Figure and Table Legends from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Figure and Table Legends from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Figure and Table Legends
View article: Supplementary Figure and Table Legends from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Figure and Table Legends from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Figure and Table Legends
View article: Supplementary Figures from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Figures from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Figures
View article: Supplementary Data File 1 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Data File 1 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
All dose-response curves. Dose-response curves for all library compounds
View article: Supplementary Figures from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Figures from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Figures
View article: Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Metabolic constraints in the tumor microenvironment constitute a barrier to effective antitumor immunity and similarities in the metabolic properties of T cells and cancer cells impede the specific therapeutic targeting of metabolism in ei…
View article: Supplementary Table S2 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Table S2 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Table S2
View article: Supplementary Table S3 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Table S3 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Table S3
View article: Supplementary Data File 1 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Data File 1 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
All dose-response curves. Dose-response curves for all library compounds
View article: Supplementary Table S3 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Table S3 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Table S3
View article: Supplementary Table S1 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Supplementary Table S1 from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Supplementary Table S1
View article: Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells
Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8<sup>+</sup> T Cells Open
Metabolic constraints in the tumor microenvironment constitute a barrier to effective antitumor immunity and similarities in the metabolic properties of T cells and cancer cells impede the specific therapeutic targeting of metabolism in ei…