Alison E. White
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View article: Melbournevirus-encoded histone doublets are recruited to virus particles and form destabilized nucleosome-like structures
Melbournevirus-encoded histone doublets are recruited to virus particles and form destabilized nucleosome-like structures Open
Summary The organization of genomic DNA into defined nucleosomes has long been viewed as a hallmark of eukaryotes. This paradigm has been challenged by the identification of ‘minimalist’ histones in archaea, and more recently by the discov…
View article: Structure of histone-based chromatin in Archaea
Structure of histone-based chromatin in Archaea Open
Origin of DNA compaction As a repeating unit in eukaryotic chromatin, a nucleosome wraps DNA in superhelical turns around a histone octamer. Mattiroli et al. present the crystal structure of an archaeal histone-DNA complex in which the his…
View article: A quantitative investigation of linker histone interactions with nucleosomes and chromatin
A quantitative investigation of linker histone interactions with nucleosomes and chromatin Open
Linker histones such as H1 are abundant basic proteins that bind tightly to nucleosomes, thereby acting as key organizers of chromatin structure. The molecular details of linker histone interactions with the nucleosome and in particular th…