Alison Howarth
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View article: Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population
Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population Open
View article: Selective ROCK Inhibitor Enhances Blood Flow Recovery after Hindlimb Ischemia
Selective ROCK Inhibitor Enhances Blood Flow Recovery after Hindlimb Ischemia Open
The impairment in microvascular network formation could delay the restoration of blood flow after acute limb ischemia. A high-content screen of a GSK-published kinase inhibitor library identified a set of ROCK inhibitor hits enhancing endo…
View article: SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection
SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection Open
View article: Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses Open
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of f…
View article: Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines
Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines Open
View article: The challenge of limited vaccine supplies: impact of prior infection on anti-spike IgG antibody trajectories after a single COVID-19 vaccination
The challenge of limited vaccine supplies: impact of prior infection on anti-spike IgG antibody trajectories after a single COVID-19 vaccination Open
Given high SARS-CoV-2 incidence, coupled with slow and inequitable vaccine roll-out, there is an urgent need for evidence to underpin optimum vaccine deployment, aiming to maximise global population immunity at speed. We evaluate whether a…
View article: Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom
Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom Open
Background “Classic” symptoms (cough, fever, loss of taste/smell) prompt severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing in the United Kingdom. Studies have assessed the ability of diffe…
View article: Anti-spike antibody response to natural SARS-CoV-2 infection in the general population
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population Open
View article: SARS-CoV-2 anti-spike IgG antibody responses after second dose of ChAdOx1 or BNT162b2 and correlates of protection in the UK general population
SARS-CoV-2 anti-spike IgG antibody responses after second dose of ChAdOx1 or BNT162b2 and correlates of protection in the UK general population Open
We investigated anti-spike IgG antibody responses and correlates of protection following second doses of ChAdOx1 or BNT162b2 SARS-CoV-2 vaccines in the UK general population. In 222,493 individuals, we found significant boosting of anti-sp…
View article: Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom Open
View article: Anti-spike antibody response to natural SARS-CoV-2 infection in the general population
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population Open
We estimated the duration and determinants of antibody response after SARS-CoV-2 infection in the general population using representative data from 7,256 United Kingdom COVID-19 infection survey participants who had positive swab SARS-CoV-…
View article: An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status
An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status Open
Background Natural and vaccine-induced immunity will play a key role in controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. SARS-CoV-2 variants have the potential to evade natural and vaccine-induced immu…
View article: Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status
Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status Open
View article: CCDC 1960280: Experimental Crystal Structure Determination
CCDC 1960280: Experimental Crystal Structure Determination Open
View article: PIN50 Leveraging Publicly Available Data to Estimate a Real-Time Reproduction Number (Rt) for Covid-19: A Comparison of Two Methods
PIN50 Leveraging Publicly Available Data to Estimate a Real-Time Reproduction Number (Rt) for Covid-19: A Comparison of Two Methods Open
View article: Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses Open
Summary It is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-c…
View article: The impact of SARS-CoV-2 vaccines on antibody responses in the general population in the United Kingdom
The impact of SARS-CoV-2 vaccines on antibody responses in the general population in the United Kingdom Open
Real-world data on antibody response post-vaccination in the general population are limited. 45,965 adults in the UK’s national COVID-19 Infection Survey receiving Pfizer-BioNTech or Oxford-AstraZeneca vaccines had 111,360 anti-spike IgG m…
View article: Quantitative SARS-CoV-2 anti-spike responses to Pfizer-BioNTech and Oxford-AstraZeneca vaccines by previous infection status
Quantitative SARS-CoV-2 anti-spike responses to Pfizer-BioNTech and Oxford-AstraZeneca vaccines by previous infection status Open
Objectives We investigate determinants of SARS-CoV-2 anti-spike IgG responses in healthcare workers (HCWs) following one or two doses of Pfizer-BioNTech or Oxford-AstraZeneca vaccines. Methods HCWs participating in regular SARS-CoV-2 PCR a…
View article: An observational cohort study on the incidence of SARS-CoV-2 infection and B.1.1.7 variant infection in healthcare workers by antibody and vaccination status
An observational cohort study on the incidence of SARS-CoV-2 infection and B.1.1.7 variant infection in healthcare workers by antibody and vaccination status Open
Background Natural and vaccine-induced immunity will play a key role in controlling the SARS-CoV-2 pandemic. SARS-CoV-2 variants have the potential to evade natural and vaccine-induced immunity. Methods In a longitudinal cohort study of he…
View article: Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections
Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections Open
View article: The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers
The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody measurements can be used to estimate the proportion of a population exposed or infected and may be informative about the risk of future…
View article: Cell-permeable lanthanide–platinum(<scp>iv</scp>) anti-cancer prodrugs
Cell-permeable lanthanide–platinum(<span>iv</span>) anti-cancer prodrugs Open
Heterometallic Eu/Gd Pt(iv) complexes have been synthesised and characterised. The Eu–Pt(iv) complex shows a luminescent “switch-on” effect upon reduction.
View article: Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses
Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses Open
View article: Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers Open
The presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months. (Funded by the U.K. Government Department of Health and Social Care and othe…
View article: Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey
Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey Open
View article: Activin A receptor, type I (ACVR1); A Target Enabling Package
Activin A receptor, type I (ACVR1); A Target Enabling Package Open
<p>Germline gain of function mutations in the gene <em>ACVR1</em> encoding the BMP receptor ALK2 lead to the rare congenital syndrome FOP in which aberrant signalling through the BMP signalling pathway leads to progressiv…
View article: Activin A receptor, type I (ACVR1); A Target Enabling Package
Activin A receptor, type I (ACVR1); A Target Enabling Package Open
Germline gain of function mutations in the gene ACVR1 encoding the BMP receptor ALK2 lead to the rare congenital syndrome FOP in which aberrant signalling through the BMP signalling pathway leads to progressive heterotopic ossific…
View article: Activin A receptor, type I (ACVR1); A Target Enabling Package
Activin A receptor, type I (ACVR1); A Target Enabling Package Open
<p>Germline gain of function mutations in the gene <em>ACVR1</em> encoding the BMP receptor ALK2 lead to the rare congenital syndrome FOP in which aberrant signalling through the BMP signalling pathway leads to progressiv…
View article: Antibodies to SARS-CoV-2 are associated with protection against reinfection
Antibodies to SARS-CoV-2 are associated with protection against reinfection Open
Background It is critical to understand whether infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) protects from subsequent reinfection. Methods We investigated the incidence of SARS-CoV-2 PCR-positive results in s…
View article: The duration, dynamics and determinants of SARS-CoV-2 antibody responses in individual healthcare workers
The duration, dynamics and determinants of SARS-CoV-2 antibody responses in individual healthcare workers Open
Background SARS-CoV-2 IgG antibody measurements can be used to estimate the proportion of a population exposed or infected and may be informative about the risk of future infection. Previous estimates of the duration of antibody responses …