Alison Jeffery
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View article: Feeding leghorn chicks during simulated transport as an early feeding strategy and the benefits of a single spray probiotic application
Feeding leghorn chicks during simulated transport as an early feeding strategy and the benefits of a single spray probiotic application Open
This study examined early, interrupted, or no feeding, with (P) or without (N) a spray-on probiotic (Lactobacillus reuteri), on chick stress, growth, gastrointestinal tract (GIT) development, microbiota, and gene expression during and afte…
View article: Collaborative care intervention for individuals with severe mental illness: the PARTNERS2 programme including complex intervention development and cluster RCT
Collaborative care intervention for individuals with severe mental illness: the PARTNERS2 programme including complex intervention development and cluster RCT Open
Background and aims Individuals living with severe mental illness such as schizophrenia and bipolar can have significant emotional, cognitive, physical and social challenges. Most people with severe mental illness in the United Kingdom do …
View article: Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results
Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results Open
Objective The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) is best managed by reduction or cessation of alcohol use, but effective treatments are lacking. We tested whether pe…
View article: The effectiveness of a primary care-based collaborative care model to improve quality of life in people with severe mental illness: PARTNERS2 cluster randomised controlled trial
The effectiveness of a primary care-based collaborative care model to improve quality of life in people with severe mental illness: PARTNERS2 cluster randomised controlled trial Open
Background Individuals living with severe mental illness can have significant emotional, physical and social challenges. Collaborative care combines clinical and organisational components. Aims We tested whether a primary care-based collab…
View article: Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease
Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease Open
Importance Current treatments manage symptoms of Parkinson disease (PD), but no known treatment slows disease progression. Preclinical and epidemiological studies support the potential use of statins as disease-modifying therapy. Objective…
View article: Mental Imagery to Reduce Alcohol-related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol
Mental Imagery to Reduce Alcohol-related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol Open
Introduction In the UK, alcohol use is the main driver of chronic liver disease and each year results in over 1 million unplanned hospital admissions and over 25 000 deaths from alcohol-related liver disease (ArLD). The only effective trea…
View article: Challenges of Incorporating Digital Health Technology Outcomes in a Clinical Trial: Experiences from PD STAT
Challenges of Incorporating Digital Health Technology Outcomes in a Clinical Trial: Experiences from PD STAT Open
Digital health technologies (DHTs) have great potential for use as clinical trial outcomes; however, practical issues need to be addressed in order to maximise their benefit. We describe our experience of incorporating two DHTs as secondar…
View article: Enhancing Trial Delivery in Parkinson’s Disease: Qualitative Insights from PD STAT
Enhancing Trial Delivery in Parkinson’s Disease: Qualitative Insights from PD STAT Open
Background: Recruitment and retention of participants in clinical trials for Parkinson’s disease (PD) is challenging. A qualitative study embedded in the PD STAT multi-centre randomised controlled trial of simvastatin for neuroprotection i…
View article: Contributions of Fat and Carbohydrate Metabolism to Glucose Homeostasis in Childhood Change With Age and Puberty: A 12-Years Cohort Study (EARLYBIRD 77)
Contributions of Fat and Carbohydrate Metabolism to Glucose Homeostasis in Childhood Change With Age and Puberty: A 12-Years Cohort Study (EARLYBIRD 77) Open
Puberty-a period when susceptibility to the onset of Type 2 diabetes (T2D) increases-is marked with profound physiological and metabolic changes. In the EarlyBird cohort, children who developed impaired fasting glycemia in adolescence alre…
View article: Contrasting impact of androgens on male and female adiposity, fat distribution and insulin resistance in childhood and adolescence (<scp>EarlyBird</scp> 75)
Contrasting impact of androgens on male and female adiposity, fat distribution and insulin resistance in childhood and adolescence (<span>EarlyBird</span> 75) Open
Summary Objectives To investigate associations between androgens (testosterone, dehydroepiandrosterone sulphate [DHEAS] and androstenedione), adiposity, fat distribution and insulin resistance (IR) during childhood and adolescence. Methods…
View article: Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76)
Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76) Open
OBJECTIVE Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hyp…
View article: Clinical and cost-effectiveness of teen online problem-solving for adolescents who have survived an acquired brain injury in the UK: protocol for a randomised, controlled feasibility study (TOPS-UK)
Clinical and cost-effectiveness of teen online problem-solving for adolescents who have survived an acquired brain injury in the UK: protocol for a randomised, controlled feasibility study (TOPS-UK) Open
Introduction Paediatric acquired brain injury is a leading cause of mortality in children in the UK. Improved treatment during the acute phase has led to increased survival rates, although with life-long morbidity in terms of social and em…
View article: Insulin Resistance during normal child growth and development is associated with a distinct blood metabolic phenotype (Earlybird 72)
Insulin Resistance during normal child growth and development is associated with a distinct blood metabolic phenotype (Earlybird 72) Open
Longitudinal analysis can differentiate metabolite signatures that precede or follow the development of greater levels of IR. In healthy normal weight children, higher levels of IR are associated with reduced levels of BCAA, ketogenesis, a…
View article: Exploring the Adolescent Fall in Physical Activity
Exploring the Adolescent Fall in Physical Activity Open
The adolescent decline in PA is consistent across different environmental settings, attributable to falls in light-intensity/habitual activity and influenced by puberty, suggesting that the inactivity of adolescence may, in part, be under …