Alison Mcrae
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View article: OR10-4 Sex as an Independent Variable in Satiety
OR10-4 Sex as an Independent Variable in Satiety Open
Background Satiety is the result of postprandial physiologic events that determine the timing for the next meal by inhibiting the sensation of hunger. It is orchestrated by the brain-gut-axis, with gastric emptying and accommodation being …
View article: Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity Open
We show how switching from a regular diet to an HCHF increases cholesterol absorption in patients with normal weight and obesity. The decrease in cholesterol absorption from an HCHF to an LCLF, on the other hand, was only seen in normal-we…
View article: A Protocol for the Cryopreservation of Human Intestinal Mucosal Biopsies Compatible With Single-Cell Transcriptomics and Ex Vivo Studies
A Protocol for the Cryopreservation of Human Intestinal Mucosal Biopsies Compatible With Single-Cell Transcriptomics and Ex Vivo Studies Open
The heterogeneity of the human intestinal epithelium has hindered the understanding of the pathophysiology of distinct specialized cell types on a single-cell basis in disease states. Described here is a workflow for the cryopreservation o…
View article: Oral Abstracts
Oral Abstracts Open
Background: Metabolic flexibility is the ability to switch fuels for oxidation in response to changes in dietary macronutrient composition. Greater metabolic flexibility to fat is associated with less weight gain. The gut hormone PYY is as…
View article: Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic
Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic Open
Objective Little is known about the predictors of response to obesity interventions. Methods In 450 participants with obesity, body composition, resting energy expenditure, satiety, satiation, eating behavior, affect, and physical activity…