Alison Murphy
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View article: Incontinence, Frailty and Care Needs in Community-Dwelling Older Adults: Findings from an ICPOP Community Specialist Team
Incontinence, Frailty and Care Needs in Community-Dwelling Older Adults: Findings from an ICPOP Community Specialist Team Open
Background Incontinence is a common condition among older adults and has been linked to adverse outcomes such as falls, infections, psychological distress, functional decline, institutionalisation, and caregiver burden. Despite its clinica…
View article: Muscle mitochondrial changes in antisynthetase syndrome and other idiopathic inflammatory myopathies
Muscle mitochondrial changes in antisynthetase syndrome and other idiopathic inflammatory myopathies Open
Mitochondria are critical for cellular function. Their dysfunction contributes to cell degeneration and death, leading to disease progression. This study examined mitochondrial changes in idiopathic inflammatory myopathies (IIMs) including…
View article: Intracellular amyloidosis in peripheral nerve and skeletal muscle
Intracellular amyloidosis in peripheral nerve and skeletal muscle Open
Amyloidosis is an etiologically heterogeneous group of disorders pathologically characterized by the extracellular deposition of amyloid fibrils, leading to tissue damage. It commonly affects the peripheral nervous system and occasionally …
Supplementary Figure 1 from Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase <i>In vivo</i> Open
Supplementary Figure 1 from Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo
Supplementary Figure 1 from Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase <i>In vivo</i> Open
Supplementary Figure 1 from Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo
Data from Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase <i>In vivo</i> Open
Purpose: Transforming growth factor-β (TGF-β) suppresses tumor development by inhibiting cellular proliferation, inducing differentiation and apoptosis, and maintaining genomic integrity. However, once tumor cells escape from the tumor-sup…
Data from Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase <i>In vivo</i> Open
Purpose: Transforming growth factor-β (TGF-β) suppresses tumor development by inhibiting cellular proliferation, inducing differentiation and apoptosis, and maintaining genomic integrity. However, once tumor cells escape from the tumor-sup…
Gene Expression Profiles Predict Emergence of Psychiatric Adverse Events in HIV/HCV-Coinfected Patients on Interferon-Based HCV Therapy Open
The efficacy of pegylated IFN-α and ribavirin (pegIFN/RBV) in the treatment of Hepatitis C infection is limited by psychiatric adverse effects (IFN-PE). Our study examined the ability of differential gene expression patterns prior to thera…
View article: Transcriptional profiling of PBMCs unravels B cell mediated immunopathogenic imprints of HCV vasculitis
Transcriptional profiling of PBMCs unravels B cell mediated immunopathogenic imprints of HCV vasculitis Open
B cell depletion therapy using rituximab has been shown to be effective in achieving remission in patients with HCV-mixed cryoglobulinemic (MC) vasculitis. Previously, we have demonstrated abnormalities in peripheral immune cells involving…