Alison Philbrook
YOU?
Author Swipe
View article: A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity in <i>C. elegans</i>
A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity in <i>C. elegans</i> Open
Lateralization of neuronal functions plays a critical role in regulating behavioral flexibility, but the underlying molecular mechanisms are challenging to establish at a single-neuron level. We previously showed that attraction of C. eleg…
View article: Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons Open
Sensory neurons contain morphologically diverse primary cilia that are built by intraflagellar transport (IFT) and house sensory signaling molecules. Since both ciliary structural and signaling proteins are trafficked via IFT, it has been …
View article: Differential modulation of sensory response dynamics by cilia structure and intraflagellar transport within and across chemosensory neurons
Differential modulation of sensory response dynamics by cilia structure and intraflagellar transport within and across chemosensory neurons Open
Sensory neurons contain morphologically diverse primary cilia that are built by intraflagellar transport (IFT) and house sensory signaling molecules. Since both ciliary structural and signaling proteins are trafficked via IFT, it has been …
View article: Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans
Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans Open
View article: Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in <i>Caenorhabditis</i> <i>elegans</i>
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in <i>Caenorhabditis</i> <i>elegans</i> Open
Developmental experiences play critical roles in shaping adult physiology and behavior. We and others previously showed that adult Caenorhabditiselegans which transiently experienced dauer arrest during development (postdauer) exhibit dist…
View article: Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components Open
[This corrects the article DOI: 10.1371/journal.pgen.1010016.].
View article: Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in<i>C. elegans</i>
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in<i>C. elegans</i> Open
Developmental experiences play critical roles in shaping adult physiology and behavior. We and others previously showed that adult C. elegans which transiently experienced dauer arrest during development (PD: post-dauer) exhibit distinct g…
View article: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components Open
The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that stabilize circuit connectivity are poorly understood. We systemically examined this …
View article: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components Open
The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that stabilize circuit connectivity are poorly understood. We systemically examined this …
View article: The URX oxygen-sensing neurons in C. elegans are ciliated
The URX oxygen-sensing neurons in C. elegans are ciliated Open
A subset of sensory neurons in C. elegans contains compartmentalized sensory structures termed cilia at their distal dendritic ends (Ward et al. 1975; Perkins et al. 1986; Doroquez et al. 2014). Cilia present on different sensory neuron ty…
View article: The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition Open
Plasticity in sensory signaling is partly mediated via regulated trafficking of signaling molecules to and from primary cilia. Tubby-related proteins regulate ciliary protein transport; however, their roles in remodeling cilia properties a…
View article: Author response: The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
Author response: The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition Open
View article: The<i>C. elegans</i>Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
The<i>C. elegans</i>Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition Open
Plasticity in sensory signaling is partly mediated via regulated trafficking of signaling molecules to and from primary cilia. Tubby-related proteins regulate ciliary protein transport; however, their roles in remodeling of cilia propertie…
View article: Neurexin directs partner-specific synaptic connectivity in C. elegans
Neurexin directs partner-specific synaptic connectivity in C. elegans Open
In neural circuits, individual neurons often make projections onto multiple postsynaptic partners. Here, we investigate molecular mechanisms by which these divergent connections are generated, using dyadic synapses in C. elegans as a model…
View article: Author response: Neurexin directs partner-specific synaptic connectivity in C. elegans
Author response: Neurexin directs partner-specific synaptic connectivity in C. elegans Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In neural circuits, individua…
View article: Molecular Mechanisms Underlying Synaptic Connectivity in C. elegans
Molecular Mechanisms Underlying Synaptic Connectivity in C. elegans Open
Proper synaptic connectivity is critical for communication between cells and information processing in the brain. Neurons are highly interconnected, forming synapses with multiple partners, and these connections are often refined during th…
View article: Excitatory neurons sculpt GABAergic neuronal connectivity in the <i>C. elegans</i> motor circuit
Excitatory neurons sculpt GABAergic neuronal connectivity in the <i>C. elegans</i> motor circuit Open
Establishing and maintaining the appropriate number of GABA synapses is key for balancing excitation and inhibition in the nervous system, though we have only a limited understanding of the mechanisms controlling GABA circuit connectivity.…
View article: Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein
Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein Open