Alison Anderson
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View article: Identification of dysregulated transcription factor activity in temporal lobe epilepsy
Identification of dysregulated transcription factor activity in temporal lobe epilepsy Open
Approximately a third of patients with epilepsy continue to have uncontrolled seizures despite appropriate treatment with available antiseizure medications (i.e. drug-resistant epilepsy). There is emerging evidence that transcription facto…
View article: In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review
In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review Open
Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal v…
View article: Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes Open
View article: Development of a Machine Learning Polyvariant Risk Prediction Model for Severe Cutaneous Adverse Drug Reactions to Carbamazepine and Other Aromatic Antiseizure Medications
Development of a Machine Learning Polyvariant Risk Prediction Model for Severe Cutaneous Adverse Drug Reactions to Carbamazepine and Other Aromatic Antiseizure Medications Open
View article: Applications for Deep Learning in Epilepsy Genetic Research
Applications for Deep Learning in Epilepsy Genetic Research Open
Epilepsy is a group of brain disorders characterised by an enduring predisposition to generate unprovoked seizures. Fuelled by advances in sequencing technologies and computational approaches, more than 900 genes have now been implicated i…
View article: GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture Open
View article: Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy
Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy Open
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of…
View article: Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells
Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells Open
The challenges in making animal models of complex human epilepsy phenotypes with varied aetiology highlights the need to develop alternative disease models that can address the limitations of animal models by effectively recapitulating hum…
View article: Author response: Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy
Author response: Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abs…
View article: An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy
An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy Open
Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, although a polygenic architecture is presumed. Current focus on single molecule or gene identification to eluci…
View article: Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy
Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy Open
There are no pharmacological disease-modifying treatments that can mitigate the seizures and comorbidities associated with established chronic temporal lobe epilepsy (TLE). This study evaluated the effect of sodium selenate in the post-sta…
View article: Network Preservation Analysis Reveals Dysregulated Synaptic Modules and Regulatory Hubs Shared Between Alzheimer’s Disease and Temporal Lobe Epilepsy
Network Preservation Analysis Reveals Dysregulated Synaptic Modules and Regulatory Hubs Shared Between Alzheimer’s Disease and Temporal Lobe Epilepsy Open
Background: There is increased prevalence of epilepsy in patients with Alzheimer’s disease (AD). Although shared pathological and clinical features have been identified, the underlying pathophysiology and cause-effect relationships are poo…
View article: Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti‐seizure medications
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti‐seizure medications Open
Objective Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Antiseizure medications (ASMs) with aromatic ring structure, including carbamazepine, are among the most common culp…
View article: One step closer towards personalized epilepsy management
One step closer towards personalized epilepsy management Open
This scientific commentary refers to ‘Towards realizing the vision of precision medicine: AI based prediction of clinical drug response’ by De Jong et al. (doi:10.1093/brain/awab108).
View article: ggVolcanoR: A Shiny app for customizable visualization of differential expression datasets
ggVolcanoR: A Shiny app for customizable visualization of differential expression datasets Open
View article: New era of personalised epilepsy management
New era of personalised epilepsy management Open
The trial and error approach to epilepsy treatment has not changed for over a century but machine learning and patient derived stem cells promise a personalised and more effective strategy, argue Patrick Kwan and colleagues
View article: Tissue-specific tolerance in fatal Covid-19
Tissue-specific tolerance in fatal Covid-19 Open
Background Tissue inflammation is associated with organ dysfunction and death in Covid-19. The efficacy of dexamethasone in preventing mortality in critical Covid-19 suggests that inflammation has a causal role in death. Whether this delet…
View article: Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load
Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load Open
Objective The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED‐induced BDs may result from a genome‐wide increase of de novo variants in the embryo, a mechanism that we investigate…
View article: Zooplankton as an Indicator of the Ecosystem Response to Bigheaded Carp Suppression via Commercial Harvest in the Illinois River (2010 – 2017)
Zooplankton as an Indicator of the Ecosystem Response to Bigheaded Carp Suppression via Commercial Harvest in the Illinois River (2010 – 2017) Open
Current levels of Asian carp harvest lead to measurable increases in zooplankton abundance and biomass meaning zooplankton are an indicator of ecosystem response to carp suppression. However, diversity especially of large bodied cladoceran…
View article: The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells
The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells Open
View article: Palmitoylation: a protein S-acylation with implications for breast cancer
Palmitoylation: a protein S-acylation with implications for breast cancer Open
Protein S -acylation is a reversible post-translational lipid modification that involves linkage of a fatty acid chain predominantly to a cysteine amino acid via a thioester bond. The fatty acid molecule is primarily palmitate, thus the te…
View article: Fish communities as indicators of ecological health in West Virginia rivers
Fish communities as indicators of ecological health in West Virginia rivers Open
Anthropogenic altered landscapes from the extraction of natural resources, urbanization, agricultural development, dam construction, and general conversion from forested to non-forested landscape have resulted in the loss of biodiversity a…