Alison Walker
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View article: Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)
Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML) Open
Background: Survival outcomes in AML are influenced by multiple patient- and disease-related factors, including age, performance status, prior malignancies or treatments, cytogenetics, and molecular features. Several studies have shown tha…
View article: Early real-world experience with revumenib outside of a clinical trial setting: A single center retrospective review of efficacy and tolerability
Early real-world experience with revumenib outside of a clinical trial setting: A single center retrospective review of efficacy and tolerability Open
Background: Revumenib was approved by the US Food and Drug Administration on 11/15/2024 as the first menin inhibitor for treatment of relapsed/refractory (R/R) acute leukemias with a KMT2A-translocation (KMT2Ar) based on data from the AUGM…
View article: Clinical and genomic landscape of STAT5B mutations in lymphoid and myeloid malignancies
Clinical and genomic landscape of STAT5B mutations in lymphoid and myeloid malignancies Open
Background: STAT5 is a critical mediator of cytokine signaling downstream of tyrosine kinases. STAT5B activating mutations – especially N642H - have emerged as oncogenic drivers in T-cell lymphoid neoplasms and recent evidence also implica…
View article: Outcomes of elderly (≥ 70) Acute Myeloid Leukemia (AML) patients receiving continued hypomethylating agent/venetoclax (HMA/VEN) versus allogeneic hematopoietic cell transplantation (HCT)
Outcomes of elderly (≥ 70) Acute Myeloid Leukemia (AML) patients receiving continued hypomethylating agent/venetoclax (HMA/VEN) versus allogeneic hematopoietic cell transplantation (HCT) Open
Introduction: HMA/VEN has transformed therapy for elderly patients with AML by improving complete remission (CR) rates, survival, and enabling more patients to proceed with curative allogeneic HCT. At the same time, implementation of safer…
View article: IDH mutant MDS: Proposal for disease subset recognition based on molecular and clinical features, and the availability of targeted therapies
IDH mutant MDS: Proposal for disease subset recognition based on molecular and clinical features, and the availability of targeted therapies Open
Introduction IDH1 & IDH2 somatic mutations (MT) are described in in 5-10 % of myelodysplastic syndromes (MDS) cases. Recognition of molecular entities is crucial, particularly in the presence of active therapy for that subset. For example,…
View article: Not so exclusive: Co-mutations in JAK2, MPL and CALR define distinct hematologic and clonal signatures
Not so exclusive: Co-mutations in JAK2, MPL and CALR define distinct hematologic and clonal signatures Open
Background: The canonical driver mutations in JAK2, CALR, and MPL are typically regarded as mutually exclusive in myeloproliferative neoplasms (MPNs). However, co-occurrence is increasingly recognized, raising questions about their clinica…
View article: Development and evaluation of a novel prehospital antidote service providing methylthioninium chloride (methylene blue) for sodium nitrite poisoning
Development and evaluation of a novel prehospital antidote service providing methylthioninium chloride (methylene blue) for sodium nitrite poisoning Open
Background Sodium nitrite has become established as a method of self-harm and suicide. Toxicity occurs primarily through the formation of methaemoglobin (MetHb). In response to a coroner request, West Midlands Ambulance Service developed a…
View article: Response to luspatercept can be predicted and improves overall survival in the real‐life treatment of LR‐MDS
Response to luspatercept can be predicted and improves overall survival in the real‐life treatment of LR‐MDS Open
We explored the impact of luspatercept therapy on overall survival (OS) and possible predictors of response in low‐risk (LR) myelodysplastic syndrome (MDS) patients. We evaluated 331 anemic patients treated with luspatercept. Hematological…
View article: A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest Open
Among adults with out-of-hospital cardiac arrest requiring drug therapy, the use of an intraosseous-first vascular access strategy did not result in higher 30-day survival than an intravenous-first strategy. (Funded by the National Institu…
View article: Motional Narrowing Effects in the Excited State Spin Populations of Mn-Doped Hybrid Perovskites
Motional Narrowing Effects in the Excited State Spin Populations of Mn-Doped Hybrid Perovskites Open
Spin-orbit coupling in the electronic states of solution-processed hybrid metal halide perovskites forms complex spin-textures in the band structures and allows for optical manipulation of the excited state spin-polarizations. Here, we rep…
View article: Bayesian parameter estimation for characterising mobile ion vacancies in perovskite solar cells
Bayesian parameter estimation for characterising mobile ion vacancies in perovskite solar cells Open
To overcome the challenges associated with poor temporal stability of perovskite solar cells, methods are required that allow for fast iteration of fabrication and characterisation, such that optimal device performance and stability may be…
View article: Bayesian optimization approach to quantify the effect of input parameter uncertainty on predictions of numerical physics simulations
Bayesian optimization approach to quantify the effect of input parameter uncertainty on predictions of numerical physics simulations Open
An understanding of how input parameter uncertainty in the numerical simulation of physical models leads to simulation output uncertainty is a challenging task. Common methods for quantifying output uncertainty, such as performing a grid o…
View article: Bayesian parameter estimation for characterising mobile ion vacancies in perovskite solar cells
Bayesian parameter estimation for characterising mobile ion vacancies in perovskite solar cells Open
To overcome the challenges associated with poor temporal stability of perovskite solar cells, methods are required that allow for fast iteration of fabrication and characterisation, such that optimal device performance and stability may be…
View article: Consensus on acute behavioural disturbance in the UK: a multidisciplinary modified Delphi study to determine what it is and how it should be managed
Consensus on acute behavioural disturbance in the UK: a multidisciplinary modified Delphi study to determine what it is and how it should be managed Open
Background Acute behavioural disturbance (ABD) is a term used in law enforcement and healthcare, but there is a lack of clarity regarding its meaning. Common language should be used across staff groups to support the identification, priori…
View article: Bayesian optimisation approach to quantify the effect of input parameter uncertainty on predictions of numerical physics simulations
Bayesian optimisation approach to quantify the effect of input parameter uncertainty on predictions of numerical physics simulations Open
An understanding of how input parameter uncertainty in the numerical simulation of physical models leads to simulation output uncertainty is a challenging task. Common methods for quantifying output uncertainty, such as performing a grid o…
View article: P492: SAFETY AND EFFICACY OF LP-108 AS MONOTHERAPY AND COMBINED WITH AZACITIDINE IN PATIENTS WITH RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROMES, CHRONIC MYELOMONOCYTIC LEUKEMIA, OR ACUTE MYELOID LEUKEMIA
P492: SAFETY AND EFFICACY OF LP-108 AS MONOTHERAPY AND COMBINED WITH AZACITIDINE IN PATIENTS WITH RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROMES, CHRONIC MYELOMONOCYTIC LEUKEMIA, OR ACUTE MYELOID LEUKEMIA Open
Background: BCL-2 inhibition to target intrinsic apoptotic pathways that confer a survival advantage to leukemic blasts has become a key therapeutic strategy for patients (pts) with myeloid malignancies. LP-108 is an oral highly potent and…
View article: P727: REFINING RISK STRATIFICATION IN CHRONIC MYELOMONOCYTIC LEUKEMIA (CMML): A COMPREHENSIVE ASSESSMENT OF THE IPSS-M AND OTHER MOLECULARLY INTEGRATED PROGNOSTIC MODELS
P727: REFINING RISK STRATIFICATION IN CHRONIC MYELOMONOCYTIC LEUKEMIA (CMML): A COMPREHENSIVE ASSESSMENT OF THE IPSS-M AND OTHER MOLECULARLY INTEGRATED PROGNOSTIC MODELS Open
Background: CMML is a hematopoietic disorder of clonal ontogeny associated with poor outcomes. Multiple molecularly informed models have been designed in hopes of improving prognostication. More recently, the IPSS-M risk model for MDS has …
View article: Ionic Accumulation as a Diagnostic Tool in Perovskite Solar Cells: Characterizing Band Alignment with Rapid Voltage Pulses
Ionic Accumulation as a Diagnostic Tool in Perovskite Solar Cells: Characterizing Band Alignment with Rapid Voltage Pulses Open
Despite record‐breaking devices, interfaces in perovskite solar cells are still poorly understood, inhibiting further progress. Their mixed ionic‐electronic nature results in compositional variations at the interfaces, depending on the his…
View article: Charge transport modelling of perovskite solar cells accounting for non-Boltzmann statistics in organic and highly-doped transport layers
Charge transport modelling of perovskite solar cells accounting for non-Boltzmann statistics in organic and highly-doped transport layers Open
We present a drift–diffusion model of a perovskite solar cell (PSC) in which carrier transport in the charge transport layers (TLs) is not based on the Boltzmann approximation to the Fermi–Dirac (FD) statistical distribution, in contrast t…
View article: Inverted hysteresis as a diagnostic tool for perovskite solar cells: Insights from the drift-diffusion model
Inverted hysteresis as a diagnostic tool for perovskite solar cells: Insights from the drift-diffusion model Open
Despite current–voltage hysteresis in perovskite solar cells (PSCs) having been the subject of significant research over the past decade, inverted hysteresis (IH), although frequently observed, is still not properly understood. Several mec…
View article: From Content to Context: Considering Embodied Implications for Film Sound Practitioners
From Content to Context: Considering Embodied Implications for Film Sound Practitioners Open
REVEALSthe ways in which practitioners negotiate the physical, mental, financial and social strains that affect their professional and personal realities.Through this, the wider scope and enduring impacts of sound work become apparent.'Fil…
View article: Drug routes in out-of-hospital cardiac arrest: A summary of current evidence
Drug routes in out-of-hospital cardiac arrest: A summary of current evidence Open
Recent evidence showing the clinical effectiveness of drug therapy in cardiac arrest has led to renewed interest in the optimal route for drug administration in adult out-of-hospital cardiac arrest. Current resuscitation guidelines support…
View article: Inverted Hysteresis in n–i–p and p–i–n Perovskite Solar Cells
Inverted Hysteresis in n–i–p and p–i–n Perovskite Solar Cells Open
A combination of experimental studies and drift‐diffusion modeling has been used to investigate the appearance of inverted hysteresis, where the area under the J–V curve for the reverse scan is lower than in the forward scan, in perovskite…
View article: Geriatric assessment for older adults receiving less-intensive therapy for acute myeloid leukemia: report of CALGB 361101
Geriatric assessment for older adults receiving less-intensive therapy for acute myeloid leukemia: report of CALGB 361101 Open
Geriatric assessment (GA) predicts survival among older adults with acute myeloid leukemia (AML) treated intensively. We evaluated the predictive utility of GA among older adults treated with low-intensity therapy on a multisite trial. We …