Alison K Ward
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View article: 64 Moderate body weight loss and one-carbon metabolite supplementation in early gestation beef heifers alters the fetal liver transcriptome.
64 Moderate body weight loss and one-carbon metabolite supplementation in early gestation beef heifers alters the fetal liver transcriptome. Open
Moderate body weight (BW) loss occurs in production cycles, particularly among heifers with increased nutrient demand from pregnancy, ultimately hindering fetal growth and development. Feed costs and associated labor create a challenge for…
View article: PSXI-27 Effects of managing mature beef bulls on divergent planes of nutrition on sperm transcriptome.
PSXI-27 Effects of managing mature beef bulls on divergent planes of nutrition on sperm transcriptome. Open
Though the effect of nutrition on testis development in young bulls has been explored, the molecular processes of the testis and sperm function in response to nutrition in mature bulls are still unknown. Thus, we investigated the effect of…
View article: 65 Moderate body weight loss and one-carbon metabolite supplementation in early gestation beef heifers alters the fetal Longissimus dorsi transcriptome.
65 Moderate body weight loss and one-carbon metabolite supplementation in early gestation beef heifers alters the fetal Longissimus dorsi transcriptome. Open
Moderate body weight (BW) loss occurs naturally throughout production cycles and is detrimental to fetal growth and development. Supplementing one-carbon metabolites may alleviate improper fetal development. The objective of this study was…
View article: Tissue-Specific Mitochondrial Functionality and Mitochondrial-Related Gene Profiles in Response to Maternal Nutrition and One-Carbon Metabolite Supplementation During Early Pregnancy in Heifers
Tissue-Specific Mitochondrial Functionality and Mitochondrial-Related Gene Profiles in Response to Maternal Nutrition and One-Carbon Metabolite Supplementation During Early Pregnancy in Heifers Open
Background: Mitochondria are essential for fetal development, regulating energy metabolism and metabolic programming. This study examined how maternal nutrition and one-carbon metabolite (OCM) supplementation during early gestation affect …
View article: Effects of Maternal Nutrition and One-Carbon Metabolite Supplementation on Fetal Jejunal Morphology and Hexose Transporter Expression in Beef Cattle
Effects of Maternal Nutrition and One-Carbon Metabolite Supplementation on Fetal Jejunal Morphology and Hexose Transporter Expression in Beef Cattle Open
The small intestine, particularly the jejunum, is a key site for nutrient absorption and metabolic activity in mature and growing ruminants [...]
View article: Review: Micronutrient supply, developmental programming, and strategic supplementation in ruminant livestock
Review: Micronutrient supply, developmental programming, and strategic supplementation in ruminant livestock Open
Developmental programming, also known as fetal programming, is the idea that changes in offspring development with both immediate and longer-term consequences can arise from in utero stress, including compromised maternal nutrition. Large …
View article: 103 Moderate body weight loss and one-carbon metabolite supplementation in pregnant beef heifers during early gestation alters maternal and fetal morphometrics
103 Moderate body weight loss and one-carbon metabolite supplementation in pregnant beef heifers during early gestation alters maternal and fetal morphometrics Open
The objective of this study was to determine if moderate changes in rate of body weight (BW) gain and dietary one-carbon metabolite (OCM) supplementation in pregnant heifers alters maternal and fetal morphometrics. In three experiments, An…
View article: Early Gestational Hepatic Lipidomic Profiles Are Modulated by One-Carbon Metabolite Supplementation and Nutrient Restriction in Beef Heifers and Fetuses
Early Gestational Hepatic Lipidomic Profiles Are Modulated by One-Carbon Metabolite Supplementation and Nutrient Restriction in Beef Heifers and Fetuses Open
Background: Maternal nutrition during early gestation induces metabolic adaptations that support maternal health and fetal development. This study evaluated the effects of maternal one-carbon metabolite (OCM: methionine, choline, folate, a…
View article: PSV-6 Impact of maternal nutrition and one-carbon metabolite supplementation during early pregnancy on glucose transporters in the bovine fetal intestine
PSV-6 Impact of maternal nutrition and one-carbon metabolite supplementation during early pregnancy on glucose transporters in the bovine fetal intestine Open
The aim of our study was to examine how maternal nutrition during early pregnancy affects the glucose transporter proteins (GLUT1 and GLUT3) in the fetal intestine and to determine whether supplementing with one-carbon metabolites (OCM) co…
View article: International Symposium on Ruminant Physiology: Maternal nutrient supply—Impacts on physiological and whole-animal outcomes in offspring
International Symposium on Ruminant Physiology: Maternal nutrient supply—Impacts on physiological and whole-animal outcomes in offspring Open
Demands for animal products are projected to increase in the future, and animal production is key to agricultural sustainability and food security; consequently, enhancing ruminant livestock production efficiencies in sustainable ways is a…
View article: International Symposium on Ruminant Physiology: One-carbon metabolism in beef cattle throughout the production cycle
International Symposium on Ruminant Physiology: One-carbon metabolism in beef cattle throughout the production cycle Open
One-carbon metabolism (OCM) is a series of connected pathways involving the methionine-folate cycles, transsulfuration, polyamine synthesis, nucleotide synthesis, free-radical scavenging, and energy metabolism. These pathways functionally …
View article: Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues
Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues Open
Introduction Maternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vita…
View article: 227 Moderate body weight loss reduces total antioxidant capacity in pregnant beef heifers and one-carbon metabolite supplementation does not mitigate this response
227 Moderate body weight loss reduces total antioxidant capacity in pregnant beef heifers and one-carbon metabolite supplementation does not mitigate this response Open
In beef heifers, body weight (BW) gain and physiological stress are important considerations for reproductive outcomes and whole herd production efficiencies. The objective of this study was to determine if dietary one-carbon metabolite (O…
View article: 425 Altering methyl donors to beef heifers during the periconceptual period impacts fetal muscle transcript abundance
425 Altering methyl donors to beef heifers during the periconceptual period impacts fetal muscle transcript abundance Open
New findings in developmental programming show an increased importance of methyl donor availability; however, effects of changing methyl donor concentration on the fetal transcriptome have yet to be identified. Differential gene expression…
View article: PSVII-13 Influence of early maternal gestational body weight gain on liver gene expression across generations in offspring
PSVII-13 Influence of early maternal gestational body weight gain on liver gene expression across generations in offspring Open
Maternal nutrition in the periconceptional period influences gene regulation in the fetal liver across generations, affecting long-term metabolism. This study aimed to examine the effects of the rate of body weight (BW) gain of the dam (F0…
View article: 429 Maternal rate of gain and one-carbon metabolites supplementation alters the gene expression profile of fetal brain during early gestation in beef heifers
429 Maternal rate of gain and one-carbon metabolites supplementation alters the gene expression profile of fetal brain during early gestation in beef heifers Open
Maternal nutritional plane during pregnancy may leave lifelong impacts on offspring in beef cattle. Given that, we hypothesized that the supplementation of one-carbon metabolites (OCM) during pregnancy would mitigate the negative effects o…
View article: PSVI-2 Multigenerational effects of maternal rate of body weight gain on fetal liver miRNA expression
PSVI-2 Multigenerational effects of maternal rate of body weight gain on fetal liver miRNA expression Open
Maternal rate of gain is critical to heifer development, pregnancy outcomes, and cow longevity. Multigenerational epigenetic effects in offspring resulting from differing levels of maternal body weight (BW) gain in heifers have not been ex…
View article: PSIV-30 Moderate maternal nutrient restriction in beef heifers reduces fetal crown-rump length at day 35 of gestation
PSIV-30 Moderate maternal nutrient restriction in beef heifers reduces fetal crown-rump length at day 35 of gestation Open
One-carbon metabolite (OCM) supplementation in beef cattle has been shown to be a novel strategy that alters programming outcomes in tissues of the developing fetus. However, information regarding growth changes to the fetus during early g…
View article: 131 DNA methylation profile in bovine fetal liver is affected by maternal vitamin and mineral supplementation during early gestation
131 DNA methylation profile in bovine fetal liver is affected by maternal vitamin and mineral supplementation during early gestation Open
Early gestation is the critical period for successful pregnancy establishment. During this period, maternal nutrition affects fetal development with potentially long-lasting consequences on offspring performance. Despite the known effects …
View article: PSV-3 Effects of maternal early gestational weight gain on multigenerational skeletal muscle gene regulation in offspring
PSV-3 Effects of maternal early gestational weight gain on multigenerational skeletal muscle gene regulation in offspring Open
Maternal nutrition during the periconceptional period may have multigenerational effects on the gene regulation of fetal skeletal muscle. This study aimed to investigate the impact of maternal rate of body weight gain (F0) during early ges…
View article: Influence of Maternal Nutrition and One-Carbon Metabolites Supplementation during Early Pregnancy on Bovine Fetal Small Intestine Vascularity and Cell Proliferation
Influence of Maternal Nutrition and One-Carbon Metabolites Supplementation during Early Pregnancy on Bovine Fetal Small Intestine Vascularity and Cell Proliferation Open
To investigate the effects of nutrient restriction and one-carbon metabolite (OCM) supplementation (folate, vitamin B12, methionine, and choline) on fetal small intestine weight, vascularity, and cell proliferation, 29 (n = 7 ± 1 per treat…
View article: Disrupted one-carbon metabolism in heifers negatively affects their health and physiology
Disrupted one-carbon metabolism in heifers negatively affects their health and physiology Open
The objective of this study was to determine the dose-dependent response of one-carbon metabolite (OCM: methionine, choline, folate, and vitamin B12) supplementation on heifer dry matter intake on fixed gain, organ mass, hematology, cytoki…
View article: Rate of body weight gain during early gestation in F0 beef heifers has effects that extend multigenerationally to the F2 fetuses
Rate of body weight gain during early gestation in F0 beef heifers has effects that extend multigenerationally to the F2 fetuses Open
Our aim was to investigate the effects of maternal (F0) body weight (BW) gain during the first 84 d of gestation on body composition, ovarian reserve, and hormonal and metabolic parameters of breeding-age F1 heifers, as well as the BW and …
View article: One-carbon metabolite supplementation increases vitamin B12, folate, and methionine cycle metabolites in beef heifers and fetuses in an energy dependent manner at day 63 of gestation
One-carbon metabolite supplementation increases vitamin B12, folate, and methionine cycle metabolites in beef heifers and fetuses in an energy dependent manner at day 63 of gestation Open
One-carbon metabolites (OCM) are metabolites and cofactors which include folate, vitamin B12, methionine, and choline that support methylation reactions. The objectives of this study were to investigate the effects of moderate changes in m…
View article: One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy
One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy Open
We hypothesized that restricted maternal nutrition and supplementation of one-carbon metabolites (OCM; methionine, folate, choline, and vitamin B12) would affect placental vascular development during early pregnancy. A total of 43 cows wer…
View article: One-carbon metabolites supplementation and nutrient restriction alter the fetal liver metabolomic profile during early gestation in beef heifers
One-carbon metabolites supplementation and nutrient restriction alter the fetal liver metabolomic profile during early gestation in beef heifers Open
Maternal nutrition is pivotal for proper fetal development, with one-carbon metabolites (OCM) playing a key role in fetal epigenetic programming through DNA and histone methylation. The study aimed to investigate the effects of nutrient re…
View article: Effects of Dietary Restriction and One-Carbon Metabolite Supplementation During the First 63 Days of Gestation on the Maternal Gut, Vaginal, and Blood Microbiota in Cattle
Effects of Dietary Restriction and One-Carbon Metabolite Supplementation During the First 63 Days of Gestation on the Maternal Gut, Vaginal, and Blood Microbiota in Cattle Open
Background: Maternal diet quality and quantity have significant impacts on both maternal and fetal health and development. The composition and function of the maternal gut microbiome is also significantly influenced by diet; however, littl…