Alastair G. Stewart
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View article: Mechanopharmacology: <i>in vitro</i> techniques to advance drug discovery
Mechanopharmacology: <i>in vitro</i> techniques to advance drug discovery Open
Mechanopharmacology is an emerging interdisciplinary field that investigates drug action using biomechanically appropriate in vitro systems to the relevant (patho)physiology. This review outlines emerging technologies and techniques which …
View article: Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness
Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness Open
Many drugs have been discontinued during phase II/III breast cancer clinical trials due to lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data. Nutrient availability in the tumour cell microenvironmen…
View article: Understanding Comorbidities of Respiratory Models as Novel Platforms for Drug Discovery
Understanding Comorbidities of Respiratory Models as Novel Platforms for Drug Discovery Open
Chronic respiratory diseases affect over 450 million people worldwide and result in 4 million deaths per year. The majority of lung diseases are treated with drugs delivered directly to the lungs. However, there is bidirectional crosstalk …
View article: Dual-Purpose Aptamer-Based Sensors for Real-Time, Multiplexable Monitoring of Metabolites in Cell Culture Media
Dual-Purpose Aptamer-Based Sensors for Real-Time, Multiplexable Monitoring of Metabolites in Cell Culture Media Open
The availability of high-frequency, real-time measurements of the concentrations of specific metabolites in cell culture systems will enable a deeper understanding of cellular metabolism and facilitate the application of good laboratory pr…
View article: IER-484 CED4a Report: AFRRI ER1 Dosimetry Characterization
IER-484 CED4a Report: AFRRI ER1 Dosimetry Characterization Open
This report presents an analytical function as the reference neutron and photon dose (normalized to an ion chamber integral) for future nuclear accident dosimeter (NAD) exercise at the Armed Forces Radiobiology Research Institute (AFRRI). …
View article: IER-484 CED3b Report: AFRRI ER1 Dosimetry Characterization
IER-484 CED3b Report: AFRRI ER1 Dosimetry Characterization Open
This report presents the preliminary work for IER 484, the characterization of the leakage radia tion field from the TRIGA reactor at the Armed Forces Radiobiology Research Institute (AFRRI). The purpose of the dose characterization is to …
View article: Editorial: Coronavirus disease (COVID-19): mechanistic basic, translational, and clinical research aimed at identification of effective preventive and therapeutic strategies
Editorial: Coronavirus disease (COVID-19): mechanistic basic, translational, and clinical research aimed at identification of effective preventive and therapeutic strategies Open
EDITORIAL article Front. Pharmacol., 13 July 2023Sec. Respiratory Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1247765
View article: Learning landscapes through technology and movement: blurring boundaries for a more-than-human pedagogy
Learning landscapes through technology and movement: blurring boundaries for a more-than-human pedagogy Open
Interest in the role of technology and movement is growing in outdoor environmental education (OEE) research. However, there are many unexamined assumptions involving both non-digital technology and movement for outdoor learners. In this p…
View article: Encountering Landscapes: an Exploration of Environment Specific Learning on an Extended Journey
Encountering Landscapes: an Exploration of Environment Specific Learning on an Extended Journey Open
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View article: Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort study
Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort study Open
Background: This study aimed to determine the sensitivity and specificity of reverse transcription PCR (RT-PCR) testing of upper respiratory tract samples from hospitalised patients with coronavirus disease 2019 (COVID-19), compared to the…
View article: Managing Exacerbations in Thunderstorm Asthma: Current Insights
Managing Exacerbations in Thunderstorm Asthma: Current Insights Open
Epidemic thunderstorm asthma (ETSA) occurs following a thunderstorm due to the interaction of environmental and immunologic factors. Whilst first reported in the 1980s, the world's largest event in Melbourne, Australia, on November 21, 201…
View article: Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer
Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer Open
Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target the molecular alterations driving tumor progression are needed. Annexin A1 is an abundant multi-functional Ca2+…
View article: Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments Open
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of NAFLD patients are estimated to have NASH. NASH is typically chara…
View article: Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort study
Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort study Open
Objectives To determine the sensitivity and specificity of RT-PCR testing of upper respiratory tract (URT) samples from hospitalised patients with COVID-19, compared to the gold standard of a clinical diagnosis. Methods All URT RT-PCR test…
View article: Molecular epidemiology of third-generation cephalosporin-resistant Enterobacteriaceae from Southeast Queensland, Australia
Molecular epidemiology of third-generation cephalosporin-resistant Enterobacteriaceae from Southeast Queensland, Australia Open
Synopsis Third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae represent a major threat to human health. Here, we captured 288 3GC-R Enterobacteriaceae clinical isolates from 264 patients presenting at a regional Australian h…
View article: On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties
On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties Open
The cytoskeletal mechanics and cell mechanical properties play an important role in cellular behaviors. In this study, in order to provide comprehensive insights into the relationship between different cytoskeletal components and cellular …
View article: Making Market Systems Work for Women Dairy Farmers in Bangladesh: A final evaluation of Oxfam's Gendered Enterprise and Markets programme in Bangladesh
Making Market Systems Work for Women Dairy Farmers in Bangladesh: A final evaluation of Oxfam's Gendered Enterprise and Markets programme in Bangladesh Open
Gendered Enterprise and Markets (GEM) is Oxfam GB’s approach to market systems development. The GEM approach facilitates change in market systems and social norms, with the aim of ensuring more sustainable livelihood opportunities for marg…
View article: A Final Evaluation of Oxfam's Gendered Enterprise and Markets Programme (2014-18): Summary of findings
A Final Evaluation of Oxfam's Gendered Enterprise and Markets Programme (2014-18): Summary of findings Open
Gendered Enterprise and Markets (GEM) is Oxfam GB’s approach to market systems development. The GEM approach facilitates change in market systems and social norms, with the aim of ensuring more sustainable livelihood opportunities for marg…
View article: On-chip cell mechanophenotyping using phase modulated surface acoustic wave
On-chip cell mechanophenotyping using phase modulated surface acoustic wave Open
A surface acoustic wave (SAW) microfluidic chip was designed to measure the compressibility of cells and to differentiate cell mechanophenotypes. Polystyrene microbeads and poly(methylmethacrylate) (PMMA) microbeads were first tested in or…
View article: A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases
A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases Open
Impaired therapeutic responses to anti-inflammatory glucocorticoids (GC) in chronic respiratory diseases are partly attributable to interleukins and transforming growth factor β1 (TGF-β1). However, previous efforts to prevent induction of …
View article: Altered energy metabolism and metabolic gene expression associated with increased metastatic capacity identified in MDA-MB-231 cell line variants
Altered energy metabolism and metabolic gene expression associated with increased metastatic capacity identified in MDA-MB-231 cell line variants Open
AIM: Despite current advances in therapies and the gradual decline in breast cancer-related mortality, metastasis remains a major therapeutic challenge for treatment. Energy reprogramming is now recognized to be an important part of tumori…
View article: TGF‐β: Master regulator of inflammation and fibrosis
TGF‐β: Master regulator of inflammation and fibrosis Open
Transforming growth factor-β (TGF-β) is one of the three related gene products TGF-β 1–3 that activate the activin-like kinase receptor, ALK5, to elicit a bewildering array of (patho)physiological effects. The label ‘master regulator’ is w…
View article: Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis
Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis Open
Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). However, therapeutic global inhibition of TGF-β is limited by unwanted immunosuppression and mitral valve defe…
View article: Association between Frequency of Consumption of Fruit, Vegetables, Nuts and Pulses and BMI: Analyses of the International Study of Asthma and Allergies in Childhood (ISAAC)
Association between Frequency of Consumption of Fruit, Vegetables, Nuts and Pulses and BMI: Analyses of the International Study of Asthma and Allergies in Childhood (ISAAC) Open
Diets which emphasize intakes of plant-based foods are recommended to reduce disease risk and for promoting healthy weight. The aim of this study was to examine the association between fruit, vegetables, pulses and nut intake and body mass…
View article: Inhibition of viral infection-induced inflammatory responses by targeting the CLOCK regulator casein kinase 1 δ/&epsilon
Inhibition of viral infection-induced inflammatory responses by targeting the CLOCK regulator casein kinase 1 δ/&epsilon Open
Background: The key CLOCK component casein kinase 1 δ/ε is implicated in TGF-β1 signalling and regulation of glucocorticoid activity. We have shown that inhibition of casein kinase 1 δ/ε with PF670462 reduces TGF-beta1-induced glucocortico…