Aliyah Morgenstern
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View article: Ac-225 Radiochemistry through the Lens of [225Ac]Ac-DOTA-TATE
Ac-225 Radiochemistry through the Lens of [225Ac]Ac-DOTA-TATE Open
View article: MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy
MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy Open
Preclinical and clinical studies increasingly show that the immune response plays a major role in radiotherapy. Here, we investigated the role of major histocompatibility complex class I (MHC-I) molecules recognized by cytotoxic CD8+<…
View article: Ac-225 radiochemistry through the lens of [225Ac]Ac-DOTA-TATE
Ac-225 radiochemistry through the lens of [225Ac]Ac-DOTA-TATE Open
View article: Jeu et développement du langage chez l’enfant à travers le cheminement scientifique d’Elinor Ochs
Jeu et développement du langage chez l’enfant à travers le cheminement scientifique d’Elinor Ochs Open
Résumé : C’est à l’occasion d’une rencontre en marge d’un colloque à Canberra, en Australie, qu’Aliyah Morgenstern a pu s’entretenir avec Elinor Ochs, anthropologue américaine dont les travaux sur la socialisation langagière à Samoa ont ét…
View article: Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas
Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas Open
Background A new, alternative option for patients with recurrent glioblastoma is targeted alpha therapy (TAT), in the form of a local administration of substance P (neurokinin type 1 receptor ligand, NK-1) labelled with 225 Ac. The purpose…
View article: Nuclear education and training activities of the Joint Research Centre of the European Commission: Maintaining and enhancing nuclear skills and competences
Nuclear education and training activities of the Joint Research Centre of the European Commission: Maintaining and enhancing nuclear skills and competences Open
Within the Euratom Research and Training Programme, the European Commission's Joint Research Centre (JRC) implements nuclear education and training initiatives which support EU policy priorities and contribute to maintaining and developing…
View article: Third-Generation Heritage Spanish Acquisition and Socialization: Word Learning and Overheard Input in an L.A.-Based Mexican Family
Third-Generation Heritage Spanish Acquisition and Socialization: Word Learning and Overheard Input in an L.A.-Based Mexican Family Open
This case study examines overheard speech in a third-generation heritage Spanish Mexican family. It presents Spanish use longitudinally and describes overheard Spanish word use in interaction. Transcribed on CLAN to create a plurilingual c…
View article: Advances in targeted alpha therapy of cancer
Advances in targeted alpha therapy of cancer Open
View article: Evaluation of the tolerability and safety of [225Ac]Ac-PSMA-I&T in patients with metastatic prostate cancer: a phase I dose escalation study
Evaluation of the tolerability and safety of [225Ac]Ac-PSMA-I&T in patients with metastatic prostate cancer: a phase I dose escalation study Open
View article: Comparative Analysis of Morphological and Functional Effects of 225Ac- and 177Lu-PSMA Radioligand Therapies (RLTs) on Salivary Glands
Comparative Analysis of Morphological and Functional Effects of 225Ac- and 177Lu-PSMA Radioligand Therapies (RLTs) on Salivary Glands Open
Most Prostate Specific Membrane Antigens (PSMAs) targeting small molecules accumulate in the salivary glands (SGs), raising concerns about SG toxicity, especially after repeated therapies or therapy with 225Ac-labeled ligands. SG toxicity …
View article: Multimodal approaches to meaning-making in family dinners
Multimodal approaches to meaning-making in family dinners Open
International audience
View article: (Inter)languaging:an integrative approach to language in its communicative habitat
(Inter)languaging:an integrative approach to language in its communicative habitat Open
International audience
View article: First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs Open
View article: Réseaux d’articles et subdivision d’entretiens : mots d'introduction pour parcourir le volume
Réseaux d’articles et subdivision d’entretiens : mots d'introduction pour parcourir le volume Open
1. Pourquoi un volume sur les travaux de Gilles Fauconnier ? La disparition de Gilles Fauconnier il y a deux ans a révélé un paradoxe scientifique et académique surprenant : alors que Fauconnier est aujourd’hui une référence internationale…
View article: Héritage des théories de Gilles Fauconnier (1944-2021) : des Espaces Mentaux à l’Intégration Conceptuelle
Héritage des théories de Gilles Fauconnier (1944-2021) : des Espaces Mentaux à l’Intégration Conceptuelle Open
La disparition de Gilles Fauconnier il y a deux ans a révélé un paradoxe scientifique et académique surprenant : alors que Fauconnier est aujourd’hui une référence internationale incontournable dans le domaine de la linguistique cognitive …
View article: Clinical Translation of Targeted α-Therapy: An Evolution or a Revolution?
Clinical Translation of Targeted α-Therapy: An Evolution or a Revolution? Open
The field of radioligand therapy has advanced greatly in recent years, driven largely by β-emitting therapies targeting somatostatin receptor-expressing tumors and the prostate-specific membrane antigen. Now, more clinical trials are under…
View article: Targeted α-Therapy Using<sup>225</sup>Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
Targeted α-Therapy Using<sup>225</sup>Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment Open
Targeted radionuclide therapy (TRT) using targeting moieties labeled with α-particle-emitting radionuclides (α-TRT) is an intensely investigated treatment approach as the short range of α-particles allows effective treatment of local lesio…
View article: Supplementary Tables from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Supplementary Tables from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Table S1. Effect of flow field in expression of PSMA by HUVEC cells in CCM. Table S2. Specific cell associated radioactivity delivered to PSMA+ HUVEC using different delivery constructs. Table S3. Viability of PSMA-positive and PSMA-negati…
View article: Figure S2 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S2 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Dissociation constants for targeted vesicle constructs.
View article: Figure S6 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S6 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Viability (evaluated after one doubling time) of PSMA-positive HUVEC as a function of delivered radioactivity per cell.
View article: Supplementary Tables from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Supplementary Tables from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Table S1. Effect of flow field in expression of PSMA by HUVEC cells in CCM. Table S2. Specific cell associated radioactivity delivered to PSMA+ HUVEC using different delivery constructs. Table S3. Viability of PSMA-positive and PSMA-negati…
View article: Figure S7 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S7 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Effect of flow field on viability of PSMA-positive HUVEC as a function of delivered radioactivity per cell.
View article: Data from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Data from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
This study aims to evaluate the effect on killing efficacy of the intracellular trafficking patterns of α-particle emitters by using different radionuclide carriers in the setting of targeted antivascular α-radiotherapy. Nanocarriers (lipi…
View article: Figure S3 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S3 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Demonstration of enhanced expression of PSMA by HUVEC exposed to cell cultured media.
View article: Figure S2 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S2 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Dissociation constants for targeted vesicle constructs.
View article: Figure S3 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S3 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Demonstration of enhanced expression of PSMA by HUVEC exposed to cell cultured media.
View article: Data from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Data from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
This study aims to evaluate the effect on killing efficacy of the intracellular trafficking patterns of α-particle emitters by using different radionuclide carriers in the setting of targeted antivascular α-radiotherapy. Nanocarriers (lipi…
View article: Figure S1 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S1 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Effect on vesicles' targeting of the content of urea-based PSMA targeting ligand, and structure of the non active targeting construct (negative control) and of the free urea-based ligand.
View article: Figure S4 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S4 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Effect of the presence of CCM on PSMA expression over time.
View article: Figure S6 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues
Figure S6 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues Open
Viability (evaluated after one doubling time) of PSMA-positive HUVEC as a function of delivered radioactivity per cell.