Anders M. Dale
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View article: PrecisionPro Fusion: Clinical validation of an automated, rigid, Prostate-Specific MRI-CT Fusion system for prostate radiotherapy planning
PrecisionPro Fusion: Clinical validation of an automated, rigid, Prostate-Specific MRI-CT Fusion system for prostate radiotherapy planning Open
View article: Acute and transient change in brain water content induced by a single electroconvulsive therapy session
Acute and transient change in brain water content induced by a single electroconvulsive therapy session Open
A single ECT-induced seizure induces a transient increase in extracellular water content without evidence of cytotoxic edema indicative of cellular injury. Our findings suggest that ECT-related brain water shifts are reversible and unlikel…
View article: Urethra contours on MRI: Multidisciplinary consensus educational atlas and reference standard for artificial intelligence benchmarking
Urethra contours on MRI: Multidisciplinary consensus educational atlas and reference standard for artificial intelligence benchmarking Open
View article: Comparing the performance of DSC and ASL for Detecting Residual and Recurrent Glioblastoma with Deep Learning and multishell diffusion MRI
Comparing the performance of DSC and ASL for Detecting Residual and Recurrent Glioblastoma with Deep Learning and multishell diffusion MRI Open
Background Differentiating recurrent tumor from post-treatment changes remains a major challenge in glioblastoma (GBM) patients. In this work, we compared the performance of two different MR perfusion techniques, dynamic susceptibility con…
View article: Post-hoc Estimation of a Quantitative Restriction Spectrum Imaging Biomarker for Prostate Cancer Detection Using Conventional MRI
Post-hoc Estimation of a Quantitative Restriction Spectrum Imaging Biomarker for Prostate Cancer Detection Using Conventional MRI Open
Background Multiparametric MRI is useful for early detection of clinically significant prostate cancer (csPCa), but its standard Apparent Diffusion Coefficient (ADC) has limited utility as a quantitative metric for automated, patient-level…
View article: Genetic Architecture of Placental Efficiency for Term Infants: Evidence from Monoaminergic Pathways and Placental Tissue Expression in the Norwegian Mother, Father and Child Cohort Study (MoBa)
Genetic Architecture of Placental Efficiency for Term Infants: Evidence from Monoaminergic Pathways and Placental Tissue Expression in the Norwegian Mother, Father and Child Cohort Study (MoBa) Open
The placenta plays a central role in supporting fetal growth. Placental efficiency (PlE) defined as the birthweight-to-placental weight ratio proves to be a key measure of its capacity to adapt to the fetal developmental demands. Although …
View article: Genetic overlap between treatment-resistant schizophrenia and smoking initiation
Genetic overlap between treatment-resistant schizophrenia and smoking initiation Open
Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is associated with non-response to…
View article: Genomic relationship between polycystic ovary syndrome and bipolar disorder
Genomic relationship between polycystic ovary syndrome and bipolar disorder Open
View article: ABCDscores: An R package for computing summary scores in the ABCD Study®
ABCDscores: An R package for computing summary scores in the ABCD Study® Open
The ABCD Study® is the largest longitudinal research study of brain development and child health across the United States. The study generates a rich multimodal dataset, including file-based raw and derivative data and a curated tabulated …
View article: Distinct metabolic signatures of Alzheimer’s and Parkinson’s disease revealed through genetic overlap with metabolic markers
Distinct metabolic signatures of Alzheimer’s and Parkinson’s disease revealed through genetic overlap with metabolic markers Open
Metabolic dysfunction is increasingly implicated in neurodegenerative diseases, yet the genetic architecture linking metabolic markers with Alzheimer’s disease (AD) and Parkinson’s disease (PD) remains unclear. We systematically analysed p…
View article: Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders
Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders Open
View article: Subjective memory concern, negative affect, and cortical microstructural integrity in community-dwelling middle-aged men
Subjective memory concern, negative affect, and cortical microstructural integrity in community-dwelling middle-aged men Open
Concerns about memory often increase with age and have been suggested as a precursor to impending memory impairment or dementia. However, subjective memory concern (SMC) has also been shown to reflect an individual’s trait-like tendency to…
View article: Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity
Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity Open
Importance The clinical heterogeneity of bipolar disorder (BD) is a major obstacle to improving diagnosis, predicting patient outcomes, and developing personalized treatments. A genetic approach is needed to deconstruct the disorder and un…
View article: Dissecting the Genetic Relationship Between Severe Mental Disorders and Autoimmune Diseases
Dissecting the Genetic Relationship Between Severe Mental Disorders and Autoimmune Diseases Open
Severe mental disorders have been linked to immune system dysfunction. While a genetic association between mental disorders and autoimmune diseases has been suggested, their genetic relationship remains incompletely understood. Utilizing a…
View article: Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort
Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort Open
There is a need for improved early psychosis detection beyond the traditional clinical high-risk strategy. Using the Norwegian Mother, Father and Child cohort study, we examined the predictive ability of self-reported psychotic experiences…
View article: Practice effects persist over two decades of cognitive testing: Implications for longitudinal research
Practice effects persist over two decades of cognitive testing: Implications for longitudinal research Open
Background Repeated cognitive testing can boost scores due to practice effects (PEs), yet it remains unclear whether PEs persist across multiple follow-ups and long durations. We examined PEs across multiple assessments from midlife to old…
View article: New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways
New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways Open
View article: Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers
Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers Open
View article: Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease
Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease Open
Individuals with psychiatric disorders frequently experience comorbid cardiometabolic conditions, complicating treatment and worsening health outcomes. Both psychiatric and cardiometabolic disorders have been individually associated with a…
View article: FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets
FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets Open
Linear mixed-effects (LME) models are commonly used for analyzing longitudinal data. However, most applications of LME models rely on random intercepts or simple, e.g., stationary, covariance. Here, we extend the Fast and Efficient Mixed-E…
View article: Seizure-induced Transient Disruptive Changes in Brain Microstructure
Seizure-induced Transient Disruptive Changes in Brain Microstructure Open
A leading hypothesis for the mechanisms of electroconvulsive therapy (ECT) posits an initial disruptive effect followed by enhanced neuroplasticity. However, direct evidence of the presumed early disruptive changes, potentially driven by s…
View article: Predicting Active Surveillance Failure for Prostate Cancer Patients in the MRI Era: a Multicentre Transatlantic Cohort Study
Predicting Active Surveillance Failure for Prostate Cancer Patients in the MRI Era: a Multicentre Transatlantic Cohort Study Open
Background and Objective MRI-driven active surveillance (AS) is increasingly used for prostate cancer (PCa) management. To determine the oncological safety of contemporary, MRI-driven AS and identify patients at higher risk of AS failure. …
View article: PURE-MRI: An International Study Assessing Physician Accuracy in Delineating the Prostate and Urethra on Prostate MRI
PURE-MRI: An International Study Assessing Physician Accuracy in Delineating the Prostate and Urethra on Prostate MRI Open
Purpose Precise delineation of genitourinary structures during prostate cancer (PCa) care is critical to optimize treatment delivery while minimizing toxicity and injury. The Prostate and UREthra on MRI (PURE-MRI) study was an internationa…
View article: Multidisciplinary Consensus Prostate Contours on Magnetic Resonance Imaging: Educational Atlas and Reference Standard for Artificial Intelligence Benchmarking
Multidisciplinary Consensus Prostate Contours on Magnetic Resonance Imaging: Educational Atlas and Reference Standard for Artificial Intelligence Benchmarking Open
View article: Neurocognitive and brain structure correlates of reading and television habits in early adolescence
Neurocognitive and brain structure correlates of reading and television habits in early adolescence Open
View article: Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset
Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset Open
View article: The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6
The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6 Open
Background: Immune dysregulation may contribute to the pathophysiology of major depressive disorder (MDD). Here we aimed to identify genetic architecture jointly associated with MDD, white blood cell (WBC) count and interleukin 6 (IL-6) le…
View article: Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study
Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study Open
Hispanic/Latino populations are admixed, with genetic contributions from multiple ancestral populations. Studies of genetic association in these admixed populations often use methods such as admixture mapping, which relies on inferred coun…
View article: Specificity of a polygenic score for aggressive prostate cancer
Specificity of a polygenic score for aggressive prostate cancer Open
To address the concern that polygenic hazard scores for prostate cancer (PCa) might not distinguish between indolent and aggressive disease, we performed case-only analyses using a 601-variant polygenic score (PHS601). We hypothesized that…
View article: Genomics yields biological and phenotypic insights into bipolar disorder
Genomics yields biological and phenotypic insights into bipolar disorder Open
Bipolar disorder is a leading contributor to the global burden of disease1. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown2. We analysed data from participants o…