Allan Tsung
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View article: Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis 3986
Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis 3986 Open
Description Introduction Surgery-induced immunologic disturbances contribute to colorectal cancer liver metastases (CRLM) recurrence. Exercise modulates immune responses, yet its role in surgical stress-promoted CRLM is unclear. This study…
View article: Comprehensive Analysis of Genomic Variations in Pancreatic Adenocarcinoma by Race
Comprehensive Analysis of Genomic Variations in Pancreatic Adenocarcinoma by Race Open
Purpose Racial disparities in pancreatic ductal adenocarcinoma (PDAC) incidence and outcomes persist even after adjusting for access to care and treatment received, suggesting a role for tumor‐specific molecular factors. This study aimed t…
View article: Evaluation of a Novel Pan-RAS Inhibitor in 3D Bioprinted Tumor Models
Evaluation of a Novel Pan-RAS Inhibitor in 3D Bioprinted Tumor Models Open
Background: Colorectal cancer (CRC) remains a significant global health burden, with KRAS mutations driving ~40% of cases. The efficacy of recently approved, mutant-specific KRAS inhibitors is limited by mutational status as well as intrin…
View article: Protocol for spatial characterization of ECM collagen-GAG in CRC tumor microenvironment
Protocol for spatial characterization of ECM collagen-GAG in CRC tumor microenvironment Open
The extracellular matrix (ECM) plays a critical role in colorectal cancer (CRC) progression and therapeutic resistance. Accurate characterization of ECM composition and architecture is essential for understanding how CRC evades therapy, ye…
View article: Outcomes for Medicaid Patients with Colorectal Cancer Are Improved in Affluent Neighborhoods, but Disparities Persist
Outcomes for Medicaid Patients with Colorectal Cancer Are Improved in Affluent Neighborhoods, but Disparities Persist Open
Background: Socioeconomic status (SES) significantly influences outcomes in colorectal cancer (CRC) patients, with those from low-SES backgrounds facing worse prognoses. However, living in an affluent neighborhood may mitigate some of thes…
View article: Health-related quality of life and survival of patients with hepatocellular carcinoma treated with transarterial chemoembolization and Yttrium-90
Health-related quality of life and survival of patients with hepatocellular carcinoma treated with transarterial chemoembolization and Yttrium-90 Open
Background Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Due to the advanced stage in which HCC presents, most patients are only eligible for transarterial chemoembolization (TACE) or radioembolization (Y 90 ). …
View article: Understanding the mechanism behind preoperative exercise therapy in patients with gastrointestinal cancers: a prospective randomized clinical trial
Understanding the mechanism behind preoperative exercise therapy in patients with gastrointestinal cancers: a prospective randomized clinical trial Open
View article: Sociodemographic Disparities in Rectal Cancer Outcomes within Academic Cancer Centers
Sociodemographic Disparities in Rectal Cancer Outcomes within Academic Cancer Centers Open
View article: ASO Author Reflections: Decoding Racial Differences in Colon Cancer Transcriptomes
ASO Author Reflections: Decoding Racial Differences in Colon Cancer Transcriptomes Open
View article: 815 Targeting neutrophil extracellular traps (NETs) to improve response to immunotherapy in colorectal liver metastasis
815 Targeting neutrophil extracellular traps (NETs) to improve response to immunotherapy in colorectal liver metastasis Open
View article: 765 DNase I targeting of neutrophil extracellular traps improves CTLA-4 immune checkpoint blockade in models of MSS/MMRO CRC
765 DNase I targeting of neutrophil extracellular traps improves CTLA-4 immune checkpoint blockade in models of MSS/MMRO CRC Open
View article: Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages
Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages Open
Sepsis-induced acute lung injury (ALI) is prevalent in patients with sepsis and has a high mortality rate. Peptidyl arginine deiminase 2 (PADI2) and PADI4 play crucial roles in mediating the host's immune response in sepsis, but their spec…
View article: Neutrophil extracellular traps in homeostasis and disease
Neutrophil extracellular traps in homeostasis and disease Open
View article: MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer
MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) poses a formidable challenge in oncology due to its limited treatment options and poor long-term survival rates. Our previous work identified MG53, a member of the tripartite motif family protein (TR…
View article: Implementation of Hepatic Artery Infusion Pump Therapy: Real‐World Single‐Center Experience
Implementation of Hepatic Artery Infusion Pump Therapy: Real‐World Single‐Center Experience Open
Background and Objectives Hepatic artery infusion pump (HAIP) therapy is an available option at highly specialized centers to treat unresectable liver tumors (e.g., colorectal liver metastases [CRLM]). This study describes the safety and o…
View article: Survival benefit associated with screening of patients at elevated risk for pancreatic cancer
Survival benefit associated with screening of patients at elevated risk for pancreatic cancer Open
Background & Objectives Screening for pancreatic cancer is recommended for individuals with a strong family history, certain genetic syndromes, or a neoplastic cyst of the pancreas. However, limited data supports a survival benefit attribu…
View article: Strategies to build a robotic liver surgery program
Strategies to build a robotic liver surgery program Open
Over the past few decades, an increasing proportion of abdominal surgeries are performed through minimally invasive platforms. In contrast, adaptation of minimally invasive techniques for liver surgery has garnered slower attraction due to…
View article: Comparative accuracy of four guidelines to predict high-grade dysplasia or malignancy in surgically resected pancreatic intraductal papillary mucinous neoplasms: Small nuances between guidelines lead to vastly different results
Comparative accuracy of four guidelines to predict high-grade dysplasia or malignancy in surgically resected pancreatic intraductal papillary mucinous neoplasms: Small nuances between guidelines lead to vastly different results Open
Following the 2015 AGA guideline results in the highest rate of missed HGD/malignancy, but the lowest rate of operating on IPMNs without these features; meanwhile, the 2018 ACG and the combined (absolute and relative criteria) 2018 Europea…
View article: Physical exercise in liver diseases
Physical exercise in liver diseases Open
Liver diseases contribute to ~2 million deaths each year and account for 4% of all deaths globally. Despite various treatment options, the management of liver diseases remains challenging. Physical exercise is a promising nonpharmacologica…
View article: Immunotherapy as a Complement to Surgical Management of Hepatocellular Carcinoma
Immunotherapy as a Complement to Surgical Management of Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the most common primary liver tumor in adults, and the fourth leading cause of cancer-related deaths worldwide. While surgical and ablative therapies remain the standard of care in early localized disease,…
View article: Regulatory T cell: a double-edged sword from metabolic-dysfunction-associated steatohepatitis to hepatocellular carcinoma
Regulatory T cell: a double-edged sword from metabolic-dysfunction-associated steatohepatitis to hepatocellular carcinoma Open
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming a leading cause of end-stage liver disease globally. Metabolic-dysfunction-associated steatohepatitis (MASH) represents a progressive inflammatory manifestation o…
View article: Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature
Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature Open
The treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient unde…
View article: Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC
Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC Open
Background and Aims: Metabolic dysfunction–associated steatohepatitis (MASH) fibrosis is a reversible stage of liver disease accompanied by inflammatory cell infiltration. Neutrophils extrude a meshwork of chromatin fibers to establish neu…
View article: AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism
AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism Open
Pseudomonas aeruginosa (PA) infection can cause pneumonia and sepsis by activating peptidyl-arginine deiminase (PAD) and triggering the formation of neutrophil extracellular traps (NETs). Our previous research has elucidated the cru…
View article: The implication of neutrophil extracellular traps in nonalcoholic fatty liver disease
The implication of neutrophil extracellular traps in nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) is an expanding worldwide health concern, and the underlying mechanisms contributing to its progression still need further exploration. Neutrophil extracellular traps (NETs) are intricate formations…
View article: Differential Expression and Diagnostic Value of MUC5AC Glycoforms in Pancreatic Ductal Adenocarcinoma
Differential Expression and Diagnostic Value of MUC5AC Glycoforms in Pancreatic Ductal Adenocarcinoma Open
We explored the differential expression and diagnostic value of two significant Mucin 5AC (MUC5AC) glycoforms, less-glycosylated immature (IM) and heavily-glycosylated mature (MM), in neoplastic diseases (NpD), including pancreatic ductal …
View article: Minimally invasive hepatectomy is here to stay, but more evidence is needed
Minimally invasive hepatectomy is here to stay, but more evidence is needed Open
View article: Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity Open
Chemotherapy remains the mainstay of treatment for patients with advanced liposarcoma (LPS), but response rates are only 25% and the overall survival at 5 years is dismal at 20–34%. Translation of other therapies have not been successful a…
View article: Pre-operative exercise therapy suppresses colorectal liver metastases by triggering anti-tumor trained immunity of Kupffer cells
Pre-operative exercise therapy suppresses colorectal liver metastases by triggering anti-tumor trained immunity of Kupffer cells Open
Hepatic recurrence after surgical resection of colorectal liver metastasis is the major cause of treatment failure. Pre-operative exercise therapy (PEx) has been shown to improve outcomes from major abdominal surgeries. We demonstrate that…
View article: Neutrophils Extracellular Traps (NETs) Inhibition Improves PD-1 Blockade Immunotherapy in Triple-Negative Breast Cancer
Neutrophils Extracellular Traps (NETs) Inhibition Improves PD-1 Blockade Immunotherapy in Triple-Negative Breast Cancer Open
Introduction Despite significant advances using immune checkpoint blockade therapy for patients with advanced cancer, 40–85% of patients fail to respond to therapy. Increasing evidence suggests that the tumor immune microenvironment plays …