Allan H. Young
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View article: Acceptability of active and sham home-based transcranial direct current stimulation in major depression: mixed methods qualitative analysis in a randomised controlled trial
Acceptability of active and sham home-based transcranial direct current stimulation in major depression: mixed methods qualitative analysis in a randomised controlled trial Open
NCT05202119, registered on 9th January 2022.
View article: What to target? Interventions to modulate key mechanisms underlying the trajectories of affective disorders in the transregional Collaborative Research Center 393
What to target? Interventions to modulate key mechanisms underlying the trajectories of affective disorders in the transregional Collaborative Research Center 393 Open
Background Affective disorders are associated with an enormous disease burden, necessitating research on the mechanisms of effective treatments. Objectives This article introduces the intervention projects of the transregional Collaborativ…
View article: Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics
Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics Open
D1 and D2 represent distinct neurobiological mechanisms underlying MDD. The validation in a general population-based cohort and in a cohort sample with depressive symptoms delineates mechanisms underlying heterogeneity in MDD.
View article: Generating synthetic task-based brain fingerprints for population neuroscience using deep learning
Generating synthetic task-based brain fingerprints for population neuroscience using deep learning Open
Task-based functional magnetic resonance imaging (fMRI) reveals individual differences in neural correlates of cognition but faces scalability challenges due to cognitive demands, protocol variability, and limited task coverage in large da…
View article: Lithium Point-of-Care Testing to Improve Adherence to Monitoring Guidelines and Quality of Maintenance Therapy: Protocol for a Randomised Feasibility Trial
Lithium Point-of-Care Testing to Improve Adherence to Monitoring Guidelines and Quality of Maintenance Therapy: Protocol for a Randomised Feasibility Trial Open
Lithium is the first-line treatment for bipolar disorders and a first-line augmentation option for treatment-resistant unipolar depression. Due to its narrow therapeutic window and risk of toxicity, people taking lithium require regular bl…
View article: Enhancing the quality of systematic reviews and meta-analyses
Enhancing the quality of systematic reviews and meta-analyses Open
Summary Systematic reviews and meta-analyses are often considered the highest level in evidence hierarchies, and therefore are often drawn upon when considering changes in policy. Despite journals implementing measures aiming to enhance th…
View article: Recent Advances in Psychopharmacology
Recent Advances in Psychopharmacology Open
Delivering clinical trials is a challenge, most notably due to recruitment, especially among individuals with psychiatric disorders [...]
View article: The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis Open
National Institute for Health Research, Maudsley Charity, Wellcome Trust, Medical Research Council.
View article: Efficacy of Lamotrigine in the Treatment of Unipolar and Bipolar Depression: Meta-Analysis of Acute and Maintenance Randomised Controlled Trials
Efficacy of Lamotrigine in the Treatment of Unipolar and Bipolar Depression: Meta-Analysis of Acute and Maintenance Randomised Controlled Trials Open
Background/Objectives: Lamotrigine has been widely investigated in the treatment and prevention of the emergence of symptoms of depression in unipolar and bipolar depression. This work systematically appraises published and unpublished dou…
View article: (Es)ketamine as a treatment for depressive episodes with psychotic features: systematic review
(Es)ketamine as a treatment for depressive episodes with psychotic features: systematic review Open
Background Psychotic symptoms in depression are linked to worse outcomes, and treatment options are limited. Ketamine and esketamine are effective antidepressants, yet most studies have excluded patients with a history of psychotic symptom…
View article: Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force
Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force Open
Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsi…
View article: The effects of lithium on cognition in humans: A systematic review
The effects of lithium on cognition in humans: A systematic review Open
Background: Lithium, a mainstay treatment for bipolar disorders, has shown promise in treating cognitive impairments. However, concerns about cognition-related side effects persist. Aims: We aimed to synthesise the evidence on how lithium …
View article: Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders
Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders Open
We aimed to develop and validate a risk estimation model for developing bipolar-spectrum disorders (BSD) in psychiatrically hospitalized adolescents based on clinical characteristics, including putatively prodromal symptoms. Adolescent inp…
View article: Combined family history and polygenic score prediction of major depressive disorder
Combined family history and polygenic score prediction of major depressive disorder Open
Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …
View article: Nomogram for estimating the risk of suicide attempts in major depressive disorder: integrating demographic, clinical and biochemical markers – a cross-sectional study
Nomogram for estimating the risk of suicide attempts in major depressive disorder: integrating demographic, clinical and biochemical markers – a cross-sectional study Open
Background Major depressive disorder (MDD) is a significant risk factor for suicide attempts (SA), making early identification of those most at risk crucial for effective clinical intervention. This study aimed to identify demographic, cli…
View article: British academic psychiatry at a crossroads: lessons from the past 20 years and priorities for the next 20 years
British academic psychiatry at a crossroads: lessons from the past 20 years and priorities for the next 20 years Open
The past twenty years, British academic psychiatry has made significant scientific advances in neurosciences, psychopharmacology, imaging and genetics with patients increasingly being involved as research partners. However, this progress h…
View article: Cross-sectional and longitudinal comparison of commonly used screening tools for bipolar disorders
Cross-sectional and longitudinal comparison of commonly used screening tools for bipolar disorders Open
Background: Misdiagnosis is common in bipolar disorder (BD). Currently used screening tools are brief and cost-effective, but there is a lack of understanding of their reliability over time as well as whether responses are influenced by de…
View article: Cross-sectional and longitudinal comparison of commonly used screening tools for bipolar disorders
Cross-sectional and longitudinal comparison of commonly used screening tools for bipolar disorders Open
Background: Misdiagnosis is common in bipolar disorder (BD). Currently used screening tools are brief and cost-effective, but there is a lack of understanding of their reliability over time as well as whether responses are influenced by de…
View article: Solution-focused approaches to improving the careers of women academics in psychiatry: UK viewpoint
Solution-focused approaches to improving the careers of women academics in psychiatry: UK viewpoint Open
Summary Clinical academics in psychiatry face several inequities, many of which are specific to women academics and intersectional in nature. We characterise the current state of UK academic psychiatry utilising findings of the annual Medi…
View article: Regional blood flow signatures of opioidergic modulation of ketamine in major depressive disorder: a randomised crossover study
Regional blood flow signatures of opioidergic modulation of ketamine in major depressive disorder: a randomised crossover study Open
Importance Accumulating evidence suggests that the opioid system may modulate ketamine’s rapid antidepressant effects. Ketamine acutely increases regional and global cerebral blood flow (CBF), yet opioid system influence on these changes r…
View article: Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <scp>ISBD</scp> Task Force
Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <span>ISBD</span> Task Force Open
Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to…
View article: Dopamine and Mood in Psychotic Disorders
Dopamine and Mood in Psychotic Disorders Open
Importance There is limited neurobiological or trial evidence guiding treatment of comorbid affective syndromes in psychotic disorders. Given the use of dopamine-blocking antipsychotics, understanding dopamine function across these mood st…
View article: A hyperadrenergic state in hypertension is associated with depressive symptoms and impaired stress-modulated vasomotor responses: evidence for chronic stress as a common aetiology for a hypertension/depression phenotype
A hyperadrenergic state in hypertension is associated with depressive symptoms and impaired stress-modulated vasomotor responses: evidence for chronic stress as a common aetiology for a hypertension/depression phenotype Open
Background Noradrenergic activation in the central and peripheral nervous systems is a putative mechanism explaining the link between hypertension and affective disorders. Aims We investigated whether these stress-sensitive comorbidities m…
View article: 641. AN OVERVIEW OF THE PROJECT EXPLORING GENE-DRUG PAIRS IN DOSE GUIDANCE OF ANTIDEPRESSANTS AND ANTIPSYCHOTICS
641. AN OVERVIEW OF THE PROJECT EXPLORING GENE-DRUG PAIRS IN DOSE GUIDANCE OF ANTIDEPRESSANTS AND ANTIPSYCHOTICS Open
Background Pharmacological treatment is one of the key components in the treatment of mental disorders. Unfortunately, only one-third of patients adequately responds to the initial treatment and adverse effects are very common. Genetic het…