Allen M. Minns
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View article: Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection 2954
Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection 2954 Open
Description Germinal center (GC)-derived plasma cells (PC) and memory B cells (MBC) are pivotal for the effective clearance of Plasmodium and protection against reinfections. However, suboptimal humoral immune response, emergence of drug-r…
View article: Protocol to identify and sort antigen-specific B cells from Plasmodium-infected mice
Protocol to identify and sort antigen-specific B cells from Plasmodium-infected mice Open
Here, we detail a protocol to identify an antigen-specific B cell population using SpyCage reagents tailored to bind MSP1-19 antigen in a rodent malaria model. We describe steps for the preparation of splenic single-cell suspens…
View article: Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection
Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection Open
T-dependent germinal center (GC) output, comprising plasma cells and memory B cells (MBCs), is crucial for clearance of Plasmodium infection and protection against reinfection. In this study, we examine the effect of an agonistic antibody …
View article: Microbiome-mediated modulation of immune memory to <i>P. yoelii</i> affects the resistance to secondary cerebral malaria challenge
Microbiome-mediated modulation of immune memory to <i>P. yoelii</i> affects the resistance to secondary cerebral malaria challenge Open
Malaria is caused by protozoan parasites in the genus Plasmodium. Over time individuals slowly develop clinical immunity to malaria, but this process occurs at variable rates, and the mechanism of protection is not fully understood. We hav…
View article: The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum
The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum Open
View article: CD4 T Cell–Derived IL-21 Is Critical for Sustaining <i>Plasmodium</i> Infection–Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential
CD4 T Cell–Derived IL-21 Is Critical for Sustaining <i>Plasmodium</i> Infection–Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential Open
Development of Plasmodium-specific humoral immunity is critically dependent on CD4 Th cell responses and germinal center (GC) reactions during blood-stage Plasmodium infection. IL-21, a cytokine primarily produced by CD4 T cells, is an ess…
View article: Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model Open
Multiple vaccines have been developed and licensed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). While these vaccines reduce disease severity, they do not prevent infection. To prevent infection and limit transmission, …
View article: Comparative proteomics of vesicles essential for the egress of <i>Plasmodium falciparum</i> gametocytes from red blood cells
Comparative proteomics of vesicles essential for the egress of <i>Plasmodium falciparum</i> gametocytes from red blood cells Open
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis. Egress…
View article: Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells
Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells Open
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes.Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis.Egress f…
View article: Comparative proteomics of vesicles essential for the egress of<i>Plasmodium falciparum</i>gametocytes from red blood cells
Comparative proteomics of vesicles essential for the egress of<i>Plasmodium falciparum</i>gametocytes from red blood cells Open
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis. Egress…
View article: Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cell
Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cell Open
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes.Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis.Egress f…
View article: Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells
Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells Open
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis. Egress…
View article: Development and Validation of Indirect Enzyme-Linked Immunosorbent Assays for Detecting Antibodies to SARS-CoV-2 in Cattle, Swine, and Chicken
Development and Validation of Indirect Enzyme-Linked Immunosorbent Assays for Detecting Antibodies to SARS-CoV-2 in Cattle, Swine, and Chicken Open
Multiple domestic and wild animal species are susceptible to SARS-CoV-2 infection. Cattle and swine are susceptible to experimental SARS-CoV-2 infection. The unchecked transmission of SARS-CoV-2 in animal hosts could lead to virus adaptati…
View article: Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites Open
View article: Monoclonal Antibodies to S and N SARS-CoV-2 Proteins as Probes to Assess Structural and Antigenic Properties of Coronaviruses
Monoclonal Antibodies to S and N SARS-CoV-2 Proteins as Probes to Assess Structural and Antigenic Properties of Coronaviruses Open
Antibodies targeting the spike (S) and nucleocapsid (N) proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are essential tools. In addition to important roles in the treatment and diagnosis of infection, the availabil…
View article: Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy Open
View article: Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy
Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy Open
The optimal timeframe for donating convalescent plasma to be used for COVID-19 immunotherapy is unknown. To address this important knowledge deficit, we determined in vitro live-virus neutralizing capacity and persistence of IgM and IgG an…
View article: Quantitative Estimation of IgM and IgG Antibodies Against SARS-CoV-2 v1
Quantitative Estimation of IgM and IgG Antibodies Against SARS-CoV-2 v1 Open
View article: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites Open
View article: Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites
Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites Open
Plasmodium sporozoites are transmitted from an infected mosquito to mammals in which they infect the liver. The infectivity profile of sporozoites changes as they egress from oocysts on the mosquito midgut into the hemocoel, and then invad…
View article: Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex
Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex Open
With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites may rely more on the regulation of transcript stability and turnover to provide sufficient gene regulation. Plasmodiu…
View article: A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum
A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum Open
The complex life-cycle of the human malaria parasite Plasmodium falciparum requires a high degree of tight coordination allowing the parasite to adapt to changing environments. One of the major challenges for the parasite is the human-to-m…
View article: <i>Plasmodium</i> male gametocyte development and transmission are critically regulated by general and transmission-specific members of the CAF1/CCR4/NOT complex
<i>Plasmodium</i> male gametocyte development and transmission are critically regulated by general and transmission-specific members of the CAF1/CCR4/NOT complex Open
With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites also regulate the stability and turnover of transcripts to provide more comprehensive gene regulation. Plasmodium tra…
View article: Nuclear, Cytosolic, and Surface-Localized Poly(A)-Binding Proteins of Plasmodium yoelii
Nuclear, Cytosolic, and Surface-Localized Poly(A)-Binding Proteins of Plasmodium yoelii Open
Malaria remains one of the great global health problems. The parasite that causes malaria ( Plasmodium genus) relies upon exquisite control of its transmission between vertebrate hosts and mosquitoes. One crucial way that it does so is by …