Derek B. Allison
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View article: The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1
The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1 Open
Polo-like kinase 1 (PLK1), a critical cell cycle regulator, is associated with cancer progression and negatively correlates with patient survival in cutaneous melanoma based on clinical database analysis. In a melanoma mouse model induced …
View article: Cisplatin-Loaded M1 Macrophage-Derived Vesicles Have Anti-Cancer Activity in Osteosarcoma
Cisplatin-Loaded M1 Macrophage-Derived Vesicles Have Anti-Cancer Activity in Osteosarcoma Open
Osteosarcoma (OS) is a relatively rare bone malignancy that primarily affects children and young adults and is associated with significant morbidity and mortality. Cisplatin is a mainstay of treatment, but its efficacy is limited by off-ta…
View article: Case report series: Pembrolizumab and enfortumab vedotin in plasmacytoid urothelial carcinoma
Case report series: Pembrolizumab and enfortumab vedotin in plasmacytoid urothelial carcinoma Open
Plasmacytoid urothelial carcinoma (PUC) is a rare and aggressive histologic subtype of urothelial carcinoma with no well-established treatment. Recently, the combination of pembrolizumab and enfortumab vedotin has become the standard of ca…
View article: Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1
Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1 Open
Aberrant mTORC1 activation in renal tubular epithelial cells (rTECs) is implicated as a critical driver of renal cystic diseases (RCDs), including autosomal dominant polycystic kidney disease (ADPKD) and tuberous sclerosis (TSC), yet its p…
View article: M1 macrophage-engineered vesicles have anti-cancer activity in ovarian cancer
M1 macrophage-engineered vesicles have anti-cancer activity in ovarian cancer Open
Background Ovarian cancer typically presents at an advanced stage, has a poor prognosis, and is a leading cause of cancer-related deaths in women. Extracellular vesicles (EVs) are cell membrane-derived nanoparticles that function in specif…
View article: mTORC1-Dependent Regulation of the CCL24-CCR3 Axis Controls Granuloma Formation and Maintenance in Sarcoidosis
mTORC1-Dependent Regulation of the CCL24-CCR3 Axis Controls Granuloma Formation and Maintenance in Sarcoidosis Open
Sarcoidosis is a chronic granulomatous disease marked by persistent inflammation and immune cell aggregation, yet its molecular underpinnings remain incompletely understood, hindering the development of effective targeted therapies. Here, …
View article: Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non‑Appalachian patients
Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non‑Appalachian patients Open
Emerging evidence reports that regulation of the extracellular matrix influences the progression of colorectal cancer (CRC). The present study investigated regulation of the extracellular matrix proteome in colorectal malignancy within a h…
View article: RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression Open
Castration-resistant prostate cancer (CRPC) marks the advanced and lethal stage of prostate cancer (PCa). TRIM28, also known as KAP1, is a transcriptional regulator recently shown to promote CRPC cell proliferation and xenograft tumor grow…
View article: PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer Open
Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet their increased biosynthetic and energetic demands. While cells possess the capacity for de novo serine biosynthesis, most transformed cancer cells heavily depen…
View article: Left Recurrent Laryngeal Nerve Vocal Fold Paralysis in Pediatric Patient Secondary to Mediastinal Histoplasmosis Infection
Left Recurrent Laryngeal Nerve Vocal Fold Paralysis in Pediatric Patient Secondary to Mediastinal Histoplasmosis Infection Open
Histoplasma capsulatum is a dimorphic soil-based fungus endemic to the Ohio and Mississippi River valleys and southeastern United States. An extremely rare presentation is the involvement of the mediastinum leading to vocal fold paralysis,…
View article: Hyper-Glycosylation as a Central Metabolic Driver of Alzheimer’s Disease
Hyper-Glycosylation as a Central Metabolic Driver of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by devastating degenerative decline. Metabolic disruptions are widely observed, yet their involvement in the molecular etiology of AD remains underexplored. Utilizing s…
View article: Presence of an Artificial Intelligence–powered Predictive Biomarker Is Associated with a Poor Response to Intravesical Bacillus Calmette-Guerin but Not to Intravesical Sequential Gemcitabine/Docetaxel in Patients with High-grade Non–muscle-invasive Bladder Cancer
Presence of an Artificial Intelligence–powered Predictive Biomarker Is Associated with a Poor Response to Intravesical Bacillus Calmette-Guerin but Not to Intravesical Sequential Gemcitabine/Docetaxel in Patients with High-grade Non–muscle-invasive Bladder Cancer Open
Intravesical bacillus Calmette-Guerin (BCG) is considered first-line adjuvant therapy for high-risk or high-grade non-muscle-invasive bladder cancer (NMIBC). Recently, sequential intravesical gemcitabine and docetaxel (Gem/Doce) has emerge…
View article: Folliculin (FLCN) in Thyroid Tumors: Incidence, Significance, and Role as a Driver Gene and Secondary Alteration
Folliculin (FLCN) in Thyroid Tumors: Incidence, Significance, and Role as a Driver Gene and Secondary Alteration Open
Thyroid carcinomas are driven by diverse molecular alterations, but the tumor suppressor gene folliculin (FLCN), best known for its role in Birt–Hogg–Dubé (BHD) syndrome, has received limited attention in thyroid tumors. Here, we describe …
View article: GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis
GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis Open
MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter gl…
View article: Polo-Like Kinase-1 as a Potential Prognostic Marker of Prostate Cancer Utilizing ORIEN Data
Polo-Like Kinase-1 as a Potential Prognostic Marker of Prostate Cancer Utilizing ORIEN Data Open
Polo-Like Kinase-1 (PLK1) is a key regulator of the G2/M cell cycle and has been linked to treatment resistance in prostate cancer (PCa). This study aimed to explore the correlation between PLK1 expression, determined through RNA-seq analy…
View article: Predicting Response to Intravesical BCG in High-Risk NMIBC Using an Artificial Intelligence–Powered Pathology Assay: Development and Validation in an International 12-Center Cohort
Predicting Response to Intravesical BCG in High-Risk NMIBC Using an Artificial Intelligence–Powered Pathology Assay: Development and Validation in an International 12-Center Cohort Open
We developed and validated AI-based histologic assays that identify high-risk nonmuscle-invasive bladder cancer cases at higher risk of recurrence, progression, BCG-unresponsive disease, and cystectomy, potentially aiding clinical decision…
View article: GDP-mannose 4,6-Dehydratase is a Key Driver of MYCN-amplified Neuroblastoma Core Fucosylation and Tumorigenesis
GDP-mannose 4,6-Dehydratase is a Key Driver of MYCN-amplified Neuroblastoma Core Fucosylation and Tumorigenesis Open
MYCN-amplification is a genetic hallmark of ~ 40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter g…
View article: Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD
Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD Open
PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immunotherapy, highlighting its important role in the regulation of…
View article: Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection Open
Nontuberculous mycobacteria (NTM) are environmentally ubiquitous organisms that predominately cause NTM pulmonary disease (NTMPD) in individuals over the age of 65. The incidence of NTMPD has increased in the U.S., exceeding that of Mycoba…
View article: Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression
Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression Open
Summary Hexavalent chromium (Cr(VI)) is a class I environmental carcinogen known to induce lung epithelial cell transformation and promote lung cancer progression through alterations in the cell cycle and cellular energy metabolism. In thi…