Allison Boboltz
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View article: Methods for Discerning the Impact of Mucus on Host Defenses Against Viral Infection
Methods for Discerning the Impact of Mucus on Host Defenses Against Viral Infection Open
Mucus is an important component of airway host defenses that acts by enabling the trapping and clearance of infectious materials such as bacteria and viruses. It can be difficult, however, to design experiments that independently determine…
View article: Female sex hormones enhance gonococcal colonization at the endocervix by modifying cervical mucus
Female sex hormones enhance gonococcal colonization at the endocervix by modifying cervical mucus Open
Neisseria gonorrhoeae is a human-exclusive pathogen that causes gonorrhea. Gonococci (GC) initiate female infections by colonizing the cervix, which can remain asymptomatic, cause cervicitis, or ascend to the upper female reproductive trac…
View article: Synthetic Mucus Biomaterials Synergize with Antibiofilm Agents to Combat <i>Pseudomonas aeruginosa</i> Biofilms
Synthetic Mucus Biomaterials Synergize with Antibiofilm Agents to Combat <i>Pseudomonas aeruginosa</i> Biofilms Open
Bacterial biofilms are often highly resistant to antimicrobials causing persistent infections which, when not effectively managed, can significantly worsen clinical outcomes. As such, alternatives to standard antibiotic therapies have been…
View article: Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium (Adv. Biology 4/2025)
Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium (Adv. Biology 4/2025) Open
View article: Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium
Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium Open
Prior work suggests influenza A virus (IAV) crosses the airway mucus barrier in a sialic acid‐dependent manner through the actions of the viral envelope proteins, hemagglutinin, and neuraminidase. However, host and viral factors that influ…
View article: Microrheology of gel-forming airway mucins isolated from porcine trachea
Microrheology of gel-forming airway mucins isolated from porcine trachea Open
A method to extract gel-forming mucins from pig trachea is developed. These airway mucins form viscous gels resembling human airway mucus, making them a useful model for lung disease research.
View article: Scalable Extraction of Airway Mucins from Porcine Trachea
Scalable Extraction of Airway Mucins from Porcine Trachea Open
Mucins are a major component of the innate defense system in the airways and their biological functions are important to consider in pulmonary disease research. However, the available mucus models for basic research relevant to the lung ca…
View article: Synthetic mucus barrier arrays as a nanoparticle formulation screening platform
Synthetic mucus barrier arrays as a nanoparticle formulation screening platform Open
Synthetic mucus barrier arrays are developed as a high-throughput screening platform for nanoparticle drug delivery applications.
View article: Synthetic mucus barrier arrays as a nanoparticle formulation screening platform
Synthetic mucus barrier arrays as a nanoparticle formulation screening platform Open
A mucus gel layer lines the luminal surface of tissues throughout the body to protect them from infectious agents and particulates. As a result, nanoparticle drug delivery systems delivered to these sites may become trapped in mucus and su…
View article: Mucus physically restricts influenza A viral particle access to the epithelium
Mucus physically restricts influenza A viral particle access to the epithelium Open
Prior work suggests influenza A virus (IAV) crosses the airway mucus barrier in a sialic acid-dependent manner through the actions of the viral envelope proteins, hemagglutinin and neuraminidase. However, host and viral factors that influe…
View article: Engineering<i>in vitro</i>models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials
Engineering<i>in vitro</i>models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials Open
Cystic fibrosis (CF) is a muco-obstructive lung disease where inflammatory responses due to chronic infection result in the accumulation of neutrophil extracellular traps (NETs) in the airways. NETs are web-like complexes comprised mainly …
View article: Inhaled drug delivery for the targeted treatment of asthma
Inhaled drug delivery for the targeted treatment of asthma Open
View article: Engineering <i>in vitro</i> models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials
Engineering <i>in vitro</i> models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials Open
The release and accumulation of neutrophil extracellular traps (NETs) in the airway mucus barrier is prominent in cystic fibrosis. New biomaterial-based models are developed that mimic important aspects of NET-mediated pathobiology in cyst…
View article: MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium
MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium Open
Secreted mucus is a frontline defense against respiratory infection, enabling the capture and swift removal of infectious or irritating agents from the lungs. Airway mucus is composed of two mucins: mucin 5B (MUC5B) and 5AC (MUC5AC). Toget…