Allison D. Ebert
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View article: HCMV infection of terminally differentiated neurons disrupts microtubule organization, resulting in neurite retraction
HCMV infection of terminally differentiated neurons disrupts microtubule organization, resulting in neurite retraction Open
Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms, including hearing loss, visual …
View article: High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy
High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy Open
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder affecting 1:3500 male births and is associated with myofiber degeneration, regeneration, and inflammation. Glucocorticoid treatments have been the standard of care …
View article: Stabilizing microtubules aids neurite structure and disrupts syncytia formation in human cytomegalovirus-infected human forebrain neurons
Stabilizing microtubules aids neurite structure and disrupts syncytia formation in human cytomegalovirus-infected human forebrain neurons Open
Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms including hearing loss, visual d…
View article: Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron
Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron Open
Spinal muscular atrophy (SMA) is caused by homozygous mutations in human SMN1 Expression of a duplicate gene (SMN2) primarily results in skipping of exon 7 and production of an unstable protein isoform, SMNΔ7. Although SMN2 exon skipping i…
View article: Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy
Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy Open
Spinal muscular atrophy (SMA), the top genetic cause of infant mortality, is characterized by motor neuron degeneration. Mechanisms underlying SMA pathogenesis remain largely unknown. Here, we report that the activity of cyclin-dependent k…
View article: Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons
Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons Open
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency. However, in 10%–15% of congenital cases, this beta-herpesvirus demonstrates direct …
View article: Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus
Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus Open
Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Entry of HCMV into human cells is determined by the composition of glycoproteins in viral…
View article: ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulation
ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulation Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs). The loss of MNs in ALS leads to muscle weakness and wasting, respiratory failure, and death often wi…
View article: IL-1Ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology
IL-1Ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology Open
Spinal muscular atrophy (SMA) is a pediatric genetic disorder characterized by the loss of spinal cord motor neurons. Although the mechanisms underlying motor neuron loss are not clear, current data suggest that glial cells contribute to d…
View article: Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons
Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons Open
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency. However, in 10-15% of congenital cases, this beta-herpesvirus demonstrates direct e…
View article: Neutralizing Antibodies with Neurotropic Factor Treatment Maintain Neurodevelopmental Gene Expression Upon Exposure to Human Cytomegalovirus
Neutralizing Antibodies with Neurotropic Factor Treatment Maintain Neurodevelopmental Gene Expression Upon Exposure to Human Cytomegalovirus Open
Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Infection of cerebral organoids with HCMV causes significant downregulation of genes invo…
View article: Diminished motor neuron activity driven by abnormal astrocytic <scp>EAAT1</scp> glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral <scp>SMN</scp> delivery
Diminished motor neuron activity driven by abnormal astrocytic <span>EAAT1</span> glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral <span>SMN</span> delivery Open
Spinal muscular atrophy (SMA) is characterized by the loss of the lower spinal motor neurons due to survival motor neuron (SMN) deficiency. The motor neuron cell autonomous and non‐cell autonomous disease mechanisms driving early glutamate…
View article: Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patients
Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patients Open
Individuals living with sickle cell disease (SCD) experience severe recurrent acute and chronic pain. In order to develop novel therapies, it is necessary to better understand the neurobiological mechanisms underlying SCD pain. There are m…
View article: Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization
Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization Open
Human cytomegalovirus (HCMV) is the leading cause of virus-mediated congenital birth defects. Congenitally infected infants can have a variety of symptoms manifesting within the central nervous system.
View article: Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery
Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery Open
Spinal muscular atrophy (SMA) is a pediatric neuromuscular disease characterized by the loss of the lower spinal motor neurons due to survival motor neuron (SMN) deficiency. Motor neuron dysfunction at the glutamatergic afferent synapse is…
View article: Viral mediated knockdown of <scp>GATA6</scp> in <scp>SMA iPSC</scp> ‐derived astrocytes prevents motor neuron loss and microglial activation
Viral mediated knockdown of <span>GATA6</span> in <span>SMA iPSC</span> ‐derived astrocytes prevents motor neuron loss and microglial activation Open
Spinal muscular atrophy (SMA), a pediatric genetic disorder, is characterized by the profound loss of spinal cord motor neurons and subsequent muscle atrophy and death. Although the mechanisms underlying motor neuron loss are not entirely …
View article: Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motor neuron loss is the primary phenotype, leading to muscle weakness and wasting, respiratory failure, and death. Although a portion of ALS…
View article: Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons
Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motor neuron loss is the primary phenotype, leading to muscle weakness and wasting, respiratory failure, and death. Although a portion of ALS…
View article: Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization
Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization Open
Human cytomegalovirus (HCMV) is a prevalent betaherpesvirus that is asymptomatic in healthy individuals but can cause serious disease in immunocompromised patients. HCMV is also the leading cause of viral-mediated birth defects. Many of th…
View article: Viral mediated knockdown of GATA6 in SMA iPSC-derived astrocytes prevents motor neuron loss and microglial activation
Viral mediated knockdown of GATA6 in SMA iPSC-derived astrocytes prevents motor neuron loss and microglial activation Open
Spinal muscular atrophy (SMA), a pediatric genetic disorder, is characterized by the profound loss of spinal cord motor neurons and subsequent muscle atrophy and death. Although the mechanisms underlying motor neuron loss are not entirely …
View article: Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus
Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus Open
Human cytomegalovirus (HCMV) is a beta herpesvirus that, upon congenital infection, can cause severe birth defects including vision and hearing loss, microcephaly, and seizures. Currently, no approved treatment options exist for in utero i…
View article: Assessment of CSF biomarkers and microRNA-mediated disease mechanisms in SMA
Assessment of CSF biomarkers and microRNA-mediated disease mechanisms in SMA Open
Objective: Cerebral spinal fluid (CSF) is a promising biospecimen for the detection of central nervous system (CNS) biomarkers to monitor therapeutic efficacy at the cellular level in neurological diseases. Spinal muscular atrophy (SMA) pa…
View article: The novel chaperone protein SRCP1 reduces insoluble SOD1 protein<i>in vivo</i>without extending ALS mouse lifespan
The novel chaperone protein SRCP1 reduces insoluble SOD1 protein<i>in vivo</i>without extending ALS mouse lifespan Open
Protein misfolding and aggregation are shared features of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and protein quality control disruption contributes to neuronal toxicity. Therefore, reducing protein aggre…
View article: Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinson’s Disease but does not impact sirtuin activity
Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinson’s Disease but does not impact sirtuin activity Open
Objectives: Parkinson’s disease (PD) is a common neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. Although the underlying mechanisms of dopaminergic neuron loss is not fully understood, evidenc…