Allison E. Sewell
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View article: Identifying regulators of CAR-T cell survival and adaptation in the tumor microenvironment 3676
Identifying regulators of CAR-T cell survival and adaptation in the tumor microenvironment 3676 Open
Description Chimeric antigen receptor T (CAR-T) cell therapy can lead to durable responses in patients with some hematologic malignancies yet remains largely ineffective in solid tumors. Impaired persistence of CAR-T cells and the immunosu…
View article: Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment Open
Cellular immunotherapy has revolutionized the treatment of hematologic malignancies yet has had limited success in the solid tumor microenvironment (TME). While insufficient nutrients can lead to T cell metabolic stress in the TME, the glu…
View article: Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism
Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism Open
Imbalanced effector and regulatory CD4+ T cell subsets drive many inflammatory diseases. These T cell subsets rely on distinct metabolic programs, modulation of which differentially affects T cell fate and function. Lipid metabolism is fun…
View article: Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis
Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis Open
Host immunity in sepsis has features of hyperinflammation together with progressive immunosuppression, particularly among CD4 T cells, that can predispose to secondary infections and ineffectual organ recovery. Metabolic and immunologic dy…
View article: Impaired oxidative phosphorylation drives primary tumor escape and metastasis
Impaired oxidative phosphorylation drives primary tumor escape and metastasis Open
Summary Metastasis causes most cancer deaths and reflects transitions from primary tumor escape to seeding and growth at metastatic sites. Epithelial-to-mesenchymal transition (EMT) is important early in metastasis to enable cancer cells t…
View article: Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism
Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism Open
Lipid metabolism is fundamental to CD4+ T cell metabolism yet remains poorly understood across subsets. Therefore, we performed targeted in vivo CRISPR/Cas9 screens to identify lipid-associated genes essential for T cell subset functions. …
View article: Peripheral T Cell Development and Immunophenotyping of Twins with Heterozygous <i>FOXN1</i> Mutations
Peripheral T Cell Development and Immunophenotyping of Twins with Heterozygous <i>FOXN1</i> Mutations Open
The transcription factor FOXN1 plays an established role in thymic epithelial development to mediate selection of maturing thymocytes. Patients with heterozygous loss-of-function FOXN1 variants are associated with T cell lymphopenia at bir…
View article: Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus Open
T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities. Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this potential role of iron in SLE, we performed a CRISPR screen o…