Allison Ehrlich
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View article: Investigating microbiome-AhR interactions underlying CD4+ T cell differentiation 9328
Investigating microbiome-AhR interactions underlying CD4+ T cell differentiation 9328 Open
Description One link between the environment and autoimmune disease is the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor that can bind a diverse repertoire of ligands. In a variety of autoimmune disease mouse mod…
View article: SAT-234 Hepatotoxic Effects of HFPO Homologues in Mice: Evaluating the Safety of PFOA and PFOS Replacements
SAT-234 Hepatotoxic Effects of HFPO Homologues in Mice: Evaluating the Safety of PFOA and PFOS Replacements Open
Disclosure: M. La Merrill: None. D. Guzman: None. M.L. Goodson: None. B. Lachter: None. A. Ehrlich: None. Presentation Type: Traditional Poster Presentation (Printed Poster)Science Type and Topic: Basic Scientific Research Authors: David G…
View article: Roux‐en‐Y gastric bypass surgery decreases intestinal aryl hydrocarbon receptor signaling in male mice
Roux‐en‐Y gastric bypass surgery decreases intestinal aryl hydrocarbon receptor signaling in male mice Open
The impact of Roux‐en‐Y gastric bypass (RYGB) on indole metabolism and AhR signaling is poorly understood. Therefore, we tested the hypothesis that RYGB changes the indole metabolite profile in the gut, leading to changes in AhR signaling.…
View article: Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes
Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes Open
Serially passaged rat keratinocytes exhibit dramatically attenuated induction of Cyp1a1 by aryl hydrocarbon receptor ligands such as TCDD. However, the sensitivity to induction can be restored by protein synthesis inhibition. Previous work…
View article: Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function
Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function Open
Macrophages play an essential role in the innate immune system by differentiating into functionally diverse subsets in order to fight infection, repair damaged tissues, and regulate inappropriate immune responses. This functional diversity…
View article: Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice
Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice Open
Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, which can differentially regulate host health …
View article: Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells
Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells Open
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4 + T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated eff…
View article: Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4<sup>+</sup>T cells
Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4<sup>+</sup>T cells Open
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4 + T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated eff…
View article: Quantifying DNA loss in laboratory-created latent prints due to fingerprint processing
Quantifying DNA loss in laboratory-created latent prints due to fingerprint processing Open
Fingerprints, which are associated with touch samples, typically contain a limited amount of DNA. The amount of available DNA can be further reduced when the same touch samples undergo fingerprint processing [1]. The fingerprint developmen…
View article: Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice
Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice Open
The diet represents one environmental risk factor controlling the progression of type 1 diabetes (T1D) in genetically susceptible individuals. Consequently, understanding which specific nutritional components promote or prevent the develop…
View article: TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation
TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation Open
FICZ and TCDD, two high-affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic differ…
View article: AhR activation increases IL‐2 production by alloreactive CD4<sup>+</sup>T cells initiating the differentiation of mucosal‐homing Tim3<sup>+</sup>Lag3<sup>+</sup>Tr1 cells
AhR activation increases IL‐2 production by alloreactive CD4<sup>+</sup>T cells initiating the differentiation of mucosal‐homing Tim3<sup>+</sup>Lag3<sup>+</sup>Tr1 cells Open
Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes the development of regulatory T (Treg) cells. Although AhR‐induced Foxp3 + Treg cells have been well studied, much less is known about the development …
View article: Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection
Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection Open
Infection by Leishmania ( Viannia ) panamensis , the predominant etiologic agent for cutaneous leishmaniasis in Colombia, is characterized by a chronic mixed inflammatory response. Current treatment options are plagued by toxicity, lengthy…