Allison Lim
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View article: Synergistic A-site co-doping of (Na1/2Bi1/2)xBa1−xZn1/3Nb2/3O3 perovskites: doping mechanisms, microstructure and impedance studies
Synergistic A-site co-doping of (Na1/2Bi1/2)xBa1−xZn1/3Nb2/3O3 perovskites: doping mechanisms, microstructure and impedance studies Open
This study explores the novel synergistic co-doping of (Na1/2Bi1/2)2+ ions into the A-sites of Ba(Zn1/3Nb2/3)O3 (BZN) perovskites to optimise dielectric properties and reduce sintering temperatures. Polycrystalline (Na1/2Bi1/2)xBa1−xZn1/3N…
View article: Nirogacestat—the pathway to approval of the first treatment for desmoid tumors, a rare disease
Nirogacestat—the pathway to approval of the first treatment for desmoid tumors, a rare disease Open
Drug development for rare diseases can be long, complex, and costly. Desmoid tumors (DT), a rare type of soft-tissue tumor, are associated with substantial and debilitating burden, including disease-specific symptoms (e.g., pain, impaired …
View article: Surface‐Grafted Biocompatible Polymer Conductors for Stable and Compliant Electrodes for Brain Interfaces
Surface‐Grafted Biocompatible Polymer Conductors for Stable and Compliant Electrodes for Brain Interfaces Open
Durable and conductive interfaces that enable chronic and high‐resolution recording of neural activity are essential for understanding and treating neurodegenerative disorders. These chronic implants require long‐term stability and small c…
View article: Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study
Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study Open
Introduction Nirogacestat is a targeted gamma secretase inhibitor approved in the United States for adults with progressing desmoid tumors. In the phase 3 DeFi study (NCT03785964) of nirogacestat, ovarian toxicity (OT) was identified as a …
View article: Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors Open
Nirogacestat was associated with significant benefits with respect to progression-free survival, objective response, pain, symptom burden, physical functioning, role functioning, and health-related quality of life in adults with progressin…
View article: Increasing the Strength, Hardness, and Survivability of Semiconducting Polymers by Crosslinking
Increasing the Strength, Hardness, and Survivability of Semiconducting Polymers by Crosslinking Open
Crosslinking is a ubiquitous strategy in polymer engineering to increase the thermomechanical robustness of solid polymers but has been relatively unexplored in the context of π‐conjugated (semiconducting) polymers. Notwithstanding, mechan…
View article: Polysiloxane Scintillators for Efficient Neutron and Gamma-Ray Pulse Shape Discrimination
Polysiloxane Scintillators for Efficient Neutron and Gamma-Ray Pulse Shape Discrimination Open
Plastic scintillators based on thermoplastics, such as polystyrene and poly(vinyl toluene) (PVT), are capable of neutron and γ radiation detection via pulse shape discrimination (PSD) when overdoped with select fluorescent molecules. This …
View article: Improving plastic scintillators for detection of neutrons and gamma rays
Improving plastic scintillators for detection of neutrons and gamma rays Open
Detection of special nuclear materials (SNMs) at borders and ports of entry is critical to ensuring peaceful use of fissile materials. Plastic scintillators are viable option for first line of detection for these materials due to their low…