Allison M. Manuel
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View article: Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels
Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels Open
Introduction Classically activated innate immune cells undergo a metabolic switch to aerobic glycolysis to support effector function. We report that the small-molecule nitroalkene 10-n-octadec-9-enoic acid (NO 2 -OA) attenuates the Warburg…
View article: Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis
Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves o…
View article: Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis
Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves o…
View article: Semaglutide‐induced weight loss improves mitochondrial energy efficiency in skeletal muscle
Semaglutide‐induced weight loss improves mitochondrial energy efficiency in skeletal muscle Open
Objective Glucagon‐like peptide‐1 receptor agonists (e.g., semaglutide) potently induce weight loss, thereby reducing obesity‐related complications. However, weight regain occurs when treatment is discontinued. An increase in skeletal musc…
View article: Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle
Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle Open
Objective Glucagon-like peptide 1 receptor agonists (e.g. semaglutide) potently induce weight loss and thereby reducing obesity-related complications. However, weight regain occurs when treatment is discontinued. An increase in skeletal mu…
View article: Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis
Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves o…
View article: Supplementary Figure Legend 1 and Supplementary Table 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress Open
Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
View article: Supplementary Figure Legend 1 and Supplementary Table 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress Open
Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
View article: Supplementary Figure 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress
Supplementary Figure 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress Open
S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.
View article: Supplementary Figure 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress
Supplementary Figure 1 from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress Open
S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.
View article: Data from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress
Data from Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress Open
Protein homeostasis (proteostasis) regulates tumor growth and proliferation when cells are exposed to proteotoxic stress, such as during treatment with certain chemotherapeutics. Consequently, cancer cells depend to a greater extent on str…
View article: A phage tail–like bacteriocin suppresses competitors in metapopulations of pathogenic bacteria
A phage tail–like bacteriocin suppresses competitors in metapopulations of pathogenic bacteria Open
Bacteria can repurpose their own bacteriophage viruses (phage) to kill competing bacteria. Phage-derived elements are frequently strain specific in their killing activity, although there is limited evidence that this specificity drives bac…
View article: Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency
Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency Open
View article: Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility
Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility Open
View article: Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.
View article: Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
View article: Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Protein homeostasis (proteostasis) regulates tumor growth and proliferation when cells are exposed to proteotoxic stress, such as during treatment with certain chemotherapeutics. Consequently, cancer cells depend to a greater extent on str…
View article: Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.
View article: Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
View article: Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Protein homeostasis (proteostasis) regulates tumor growth and proliferation when cells are exposed to proteotoxic stress, such as during treatment with certain chemotherapeutics. Consequently, cancer cells depend to a greater extent on str…
View article: Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
View article: Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.
View article: Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
View article: Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Protein homeostasis (proteostasis) regulates tumor growth and proliferation when cells are exposed to proteotoxic stress, such as during treatment with certain chemotherapeutics. Consequently, cancer cells depend to a greater extent on str…
View article: Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.
View article: A weaponized phage suppresses competitors in historical and modern metapopulations of pathogenic bacteria
A weaponized phage suppresses competitors in historical and modern metapopulations of pathogenic bacteria Open
Bacteriophages, the viruses of bacteria, are proposed to drive bacterial population dynamics, yet direct evidence of their impact on natural populations is limited. Here we identified viral sequences in a metapopulation of wild plant-assoc…
View article: Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress Open
Protein homeostasis (proteostasis) regulates tumor growth and proliferation when cells are exposed to proteotoxic stress, such as during treatment with certain chemotherapeutics. Consequently, cancer cells depend to a greater extent on str…
View article: Extracellular vesicles present in bone, blood and extracellular matrix have distinctive characteristics and biologic roles
Extracellular vesicles present in bone, blood and extracellular matrix have distinctive characteristics and biologic roles Open
Extracellular vesicles (EV) have long been recognized as an important means of cell to cell communication, but current metrics to delineate various subpopulations of EV are limited. Recently, a distinctive subpopulation of EV embedded with…
View article: Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study
Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study Open
Background Cyclin-dependent kinases (CDK) 4 and 6 regulate G1 to S cell cycle progression and are often altered in cancers. Abemaciclib is a selective inhibitor of CDK4 and CDK6 approved for administration on a continuous dosing schedule a…
View article: Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study
Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study Open
Background Cyclin-dependent kinases (CDK) 4 and 6 regulate G1 to S cell cycle progression and are often altered in cancers. Abemaciclib is a selective inhibitor of CDK4 and CDK6 approved for administration on a continuous dosing schedule a…