Explanipedia

Evaluation of antigen and antibody assays for surveillance of Lassa virus in peri-domestic rodents in southeastern Sierra Leone: a cross-sectional study Open

Allison R. Smither, James Koninga, Franklyn Kanneh, Momoh Foday, Matthew L. Boisen , et al. · 2025

Summary: Background: Lassa fever, caused by Lassa mammarenavirus (LASV), is a rodent-borne disease endemic to west Africa. Zoonotic surveillance of LASV provides epidemiological insights into its potential presence. We aimed to assess LASV…

Novel Tools for Lassa Virus Surveillance in Peri-domestic Rodents Open

Allison R. Smither, James Koninga, Franklyn Kanneh, Momoh Foday, Matthew L. Boisen , et al. · 2023

Background Lassa fever (LF) is a rodent-borne disease endemic to West Africa. In the absence of licensed therapeutics or vaccines, rodent exclusion from living spaces remains the primary method of preventing LF. Zoonotic surveillance of La…

Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades Open

Raphaëlle Klitting, Liana E. Kafetzopoulou, Wim Thiery, Gytis Dudas, Sophie Gryseels , et al. · 2022

Ebola virus delta peptide is an enterotoxin Open

Lilia I. Melnik, Shantanu Guha, Jenisha Ghimire, Allison R. Smither, Brandon J. Beddingfield , et al. · 2022

During the 2013-2016 West African (WA) Ebola virus (EBOV) outbreak, severe gastrointestinal symptoms were common in patients and associated with poor outcome. Delta peptide is a conserved product of post-translational processing of the abu…

Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans Open

Rodrigo Borrega, Diana K. S. Nelson, Anatoliy Koval, Nell G. Bond, Megan L. Heinrich , et al. · 2021

Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pr…

Predicting the evolution of Lassa Virus endemic area and population at risk over the next decades Open

Raphaëlle Klitting, Liana E. Kafetzopoulou, Wim Thiery, Gytis Dudas, Sophie Gryseels , et al. · 2021

Lassa fever is listed among the diseases that pose the greatest risks to public health by the World Health Organization. This severe viral hemorrhagic fever is caused by Lassa virus, a zoonotic pathogen that repeatedly spills over to human…

The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response Open

Yolanda Botti-Lodovico, Parvathy Nair, Dolo Nosamiefan, Matthew Stremlau, S. F. Schaffner , et al. · 2021

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work …

Emergence of an early SARS-CoV-2 epidemic in the United States Open

Mark Zeller, Karthik Gangavarapu, Catelyn Anderson, Allison R. Smither, John A. Vanchiere , et al. · 2021

The emergence of the COVID-19 epidemic in the United States (U.S.) went largely undetected due to inadequate testing. New Orleans experienced one of the earliest and fastest accelerating outbreaks, coinciding with Mardi Gras. To gain insig…

Successful Clearance of 300 Day SARS-CoV-2 Infection in a Subject with B-Cell Depletion Associated Prolonged (B-DEAP) COVID by REGEN-COV Anti-Spike Monoclonal Antibody Cocktail Open

Arnaud Drouin, Marc Theberge, Sharon Y. Liu, Allison R. Smither, Shelby Flaherty , et al. · 2021

A 59-year-old male with follicular lymphoma treated by anti-CD20-mediated B-cell depletion and ablative chemotherapy was hospitalized with a COVID-19 infection. Although the patient did not develop specific humoral immunity, he had a mild …

Emergence of an early SARS-CoV-2 epidemic in the United States Open

Mark Zeller, Karthik Gangavarapu, Catelyn Anderson, Allison R. Smither, John A. Vanchiere , et al. · 2021

The emergence of the early COVID-19 epidemic in the United States (U.S.) went largely undetected, due to a lack of adequate testing and mitigation efforts. The city of New Orleans, Louisiana experienced one of the earliest and fastest acce…

Ebola Virus Delta Peptide Is an Enterotoxin Open

Lilia I. Melnik, Shantanu Guha, Jenisha Ghimire, Allison R. Smither, Brandon J. Beddingfield , et al. · 2021

An Epidemiologic Study of COVID-19 Patients in a State Psychiatric Hospital: High Penetrance With Early CDC Guidelines Open

John W. Thompson, Amy J. Mikolajewski, Patricia Kissinger, Patrick McCrossen, Allison R. Smither , et al. · 2020

A high percentage of patients can become positive for COVID-19 despite following initial CDC guidelines. As such, use of masks by all patients in close-quarter settings prior to the first positive case appears warranted. Recent CDC guideli…

The Ebola Virus Δ-Peptides are Enterotoxic Viroporins In Vivo and Potentially Druggable Targets Open

Shantanu Guha, Lilia I. Melnik, Jenisha Ghimire, Allison R. Smither, Eric Wu , et al. · 2020

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