Allison E. Schloop
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View article: Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in<i>Drosophila</i>blastoderm embryos
Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in<i>Drosophila</i>blastoderm embryos Open
The NF-κB signaling pathway is a key regulatory network in mammals that controls many cellular processes, including immunity and inflammation. Of particular note is the relationship between NF-κB and its inhibitor IκBα, which sequesters NF…
View article: Discovery of membrane-permeating cyclic peptides via mRNA display
Discovery of membrane-permeating cyclic peptides via mRNA display Open
Small synthetic peptides capable of crossing biological membranes represent valuable tools in cell biology and drug delivery. While several cell-penetrating peptides (CPPs) of natural or synthetic origin have been reported, no peptide is c…
View article: Robustness of the Dorsal morphogen gradient with respect to morphogen dosage
Robustness of the Dorsal morphogen gradient with respect to morphogen dosage Open
In multicellular organisms, the timing and placement of gene expression in a developing tissue assigns the fate of each cell in the embryo in order for a uniform field of cells to differentiate into a reproducible pattern of organs and tis…
View article: Shuttling of Dorsal by Cactus: mechanism and implications
Shuttling of Dorsal by Cactus: mechanism and implications Open
In a developing animal, morphogen gradients act to pattern tissues into distinct domains of cell types. However, despite their prevalence in development, morphogen gradient formation is a matter of debate. In our recent publication, we sho…